Top

Gepubliceerd in:

12-05-2021

Quality of life of COVID-19 critically ill survivors after ICU discharge: 90 days follow-up

Auteurs: Lorenzo Gamberini, Carlo Alberto Mazzoli, Harri Sintonen, Davide Colombo, Gaetano Scaramuzzo, Davide Allegri, Tommaso Tonetti, Gianluca Zani, Chiara Capozzi, Emanuela Giampalma, Vanni Agnoletti, Filippo Becherucci, Elisabetta Bertellini, Andrea Castelli, Iacopo Cappellini, Irene Cavalli, Federico Crimaldi, Federica Damiani, Maurizio Fusari, Giovanni Gordini, Cristiana Laici, Maria Concetta Lanza, Mirco Leo, Andrea Marudi, Giuseppe Nardi, Irene Ottaviani, Raffaella Papa, Antonella Potalivo, Vito Marco Ranieri, Emanuele Russo, Stefania Taddei, Carlo Alberto Volta, Savino Spadaro, the ICU-RER COVID-19 Collaboration

Gepubliceerd in: Quality of Life Research | Uitgave 10/2021

Abstract

Purpose

The onset of the coronavirus disease 19 (COVID-19) pandemic in Italy induced a dramatic increase in the need for intensive care unit (ICU) beds for a large proportion of patients affected by COVID-19-related acute respiratory distress syndrome (ARDS). The aim of the present study was to describe the health-related quality of life (HRQoL) at 90 days after ICU discharge in a cohort of COVID-19 patients undergoing invasive mechanical ventilation and to compare it with an age and sex-matched sample from the general Italian and Finnish populations. Moreover, the possible associations between clinical, demographic, social factors, and HRQoL were investigated.

Methods

COVID-19 ARDS survivors from 16 participating ICUs were followed up until 90 days after ICU discharge and the HRQoL was evaluated with the 15D instrument. A parallel cohort of age and sex-matched Italian population from the same geographic areas was interviewed and a third group of matched Finnish population was extracted from the Finnish 2011 National Health survey. A linear regression analysis was performed to evaluate potential associations between the evaluated factors and HRQoL.

Results

205 patients answered to the questionnaire. HRQoL of the COVID-19 ARDS patients was significantly lower than the matched populations in both physical and mental dimensions. Age, sex, number of comorbidities, ARDS class, duration of invasive mechanical ventilation, and occupational status were found to be significant determinants of the 90 days HRQoL. Clinical severity at ICU admission was poorly correlated to HRQoL.

Conclusion

COVID-19-related ARDS survivors at 90 days after ICU discharge present a significant reduction both on physical and psychological dimensions of HRQoL measured with the 15D instrument.

Trial Registration: NCT04411459.

vorige artikel The impact of lockdown during the COVID-19 pandemic on mental and social health of children and adolescents

volgende artikel Assessing hospitalized patients’ quality of life from external indices: the perspectives of lay people and health professionals

Alleen toegankelijk voor geautoriseerde gebruikers

WHO. (2020). WHO announces COVID-19 outbreak a pandemic.

Aziz, Shadman, Arabi, Yaseen M., Alhazzani, Waleed, Evans, Laura, Citerio, Giuseppe, Fischkoff, Katherine, Salluh, Jorge, Meyfroidt, Geert, Alshamsi, Fayez, Oczkowski, Simon, Azoulay, Elie, Price, Amy, Burry, Lisa, Dzierba, Amy, Benintende, Andrew, Morgan, Jill, Grasselli, Giacomo, Rhodes, Andrew, Møller, Morten H., … Christian, Michael D. (2020). Managing ICU surge during the COVID-19 crisis: rapid guidelines. Intensive Care Medicine, 46(7), 1303–1325. https://doi.org/10.1007/s00134-020-06092-5CrossRefPubMed

Grasselli, G., Pesenti, A., & Cecconi, M. (2020). Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy. JAMA. https://doi.org/10.1001/jama.2020.4031CrossRefPubMedPubMedCentral

Melegari, G., Giuliani, E., Maini, G., Barbieri, L., Baffoni, P., Bertellini, E., & Barbieri, A. (2020). Novel coronavirus (2019-nCov): do you have enough intensive care units? Medicina Intensiva, 44(9), 583–585. https://doi.org/10.1016/j.medin.2020.04.007CrossRefPubMedPubMedCentral

Grasselli, G., Zangrillo, A., Zanella, A., Antonelli, M., Cabrini, L., Castelli, A., & Pesenti, A. (2020). Baseline Characteristics and Outcomes of 1591 Patients Infected with SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA - Journal of the American Medical Association, 323(16), 1574–1581. https://doi.org/10.1001/jama.2020.5394CrossRefPubMed

Richardson, S., Hirsch, J. S., Narasimhan, M., Crawford, J. M., McGinn, T., Davidson, K. W., & Zanos, T. P. (2020). Presenting Characteristics, Comorbidities, and Outcomes among 5700 Patients Hospitalized with COVID-19 in the New York City Area. JAMA - Journal of the American Medical Association, 323(20), 2052–2059. https://doi.org/10.1001/jama.2020.6775CrossRefPubMed

Auld, S. C., Caridi-Scheible, M., Blum, J. M., Robichaux, C., Kraft, C., Jacob, J. T., & Murphy, D. J. (2020). ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019. Critical Care Medicine, Publish Ah. https://doi.org/10.1097/ccm.0000000000004457CrossRef

Grasselli, G., Greco, M., Zanella, A., Albano, G., Antonelli, M., Bellani, G., & Cecconi, M. (2020). Risk Factors Associated with Mortality among Patients with COVID-19 in Intensive Care Units in Lombardy, Italy. JAMA Internal Medicine. https://doi.org/10.1001/jamainternmed.2020.3539CrossRefPubMedPubMedCentral

Quah, P., Li, A., Phua, J., & Phua, J. (2020). Mortality rates of patients with COVID-19 in the intensive care unit: A systematic review of the emerging literature. Critical Care, 24(1), 1–4. https://doi.org/10.1186/s13054-020-03006-1CrossRef

10.

Lopez, M., Bell, K., Annaswamy, T., Juengst, S., & Ifejika, N. (2020). COVID-19 Guide for the Rehabilitation Clinician: A Review of Nonpulmonary Manifestations and Complications. American journal of physical medicine & rehabilitation, 99(8), 669–673. https://doi.org/10.1097/PHM.0000000000001479CrossRef

11.

Jaffri, A., & Jaffri, U. A. (2020). Post-Intensive care syndrome and COVID-19: crisis after a crisis? Heart and Lung. https://doi.org/10.1016/j.hrtlng.2020.06.006CrossRefPubMed

12.

Colbenson, G. A., Johnson, A., & Wilson, M. E. (2019). Post-intensive care syndrome: Impact, prevention, and management. Breathe, 15(2), 98–101. https://doi.org/10.1183/20734735.0013-2019CrossRefPubMedPubMedCentral

13.

Stollings, J. L., & Caylor, M. M. (2015). Postintensive care syndrome and the role of a follow-up clinic. American Journal of Health-System Pharmacy, 72(15), 1315–1323. https://doi.org/10.2146/ajhp140533CrossRefPubMed

14.

Jackson, J. C., Pandharipande, P. P., Girard, T. D., Brummel, N. E., Thompson, J. L., Hughes, C. G., & Ely, E. W. (2014). Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: A longitudinal cohort study. The Lancet Respiratory Medicine, 2(5), 369–379. https://doi.org/10.1016/S2213-2600(14)70051-7CrossRefPubMedPubMedCentral

15.

Sasannejad, C., Ely, E. W., & Lahiri, S. (2019). Long-term cognitive impairment after acute respiratory distress syndrome: A review of clinical impact and pathophysiological mechanisms. Critical Care, 23(1), 1–12. https://doi.org/10.1186/s13054-019-2626-zCrossRef

16.

Gayat, E., Cariou, A., Deye, N., Vieillard-Baron, A., Jaber, S., Damoisel, C., & Mebazaa, A. (2018). Determinants of long-term outcome in ICU survivors: Results from the FROG-ICU study. Critical Care, 22(1), 1–10. https://doi.org/10.1186/s13054-017-1922-8CrossRef

17.

Bein, T., Weber-Carstens, S., & Apfelbacher, C. (2018). Long-term outcome after the acute respiratory distress syndrome: Different from general critical illness? Current Opinion in Critical Care, 24(1), 35–40. https://doi.org/10.1097/MCC.0000000000000476CrossRefPubMedPubMedCentral

18.

Chiumello, D., Coppola, S., Froio, S., & Gotti, M. (2016). What’s next after ARDS: Long-term outcomes. Respiratory Care, 61(5), 689–699. https://doi.org/10.4187/respcare.04644CrossRefPubMed

19.

Brummel, N. E., Jackson, J. C., Pandharipande, P. P., Thompson, J. L., Shintani, A. K., Dittus, R. S., & Girard, T. D. (2014). Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Critical Care Medicine, 42(2), 369–377. https://doi.org/10.1097/CCM.0b013e3182a645bdCrossRefPubMed

20.

Stam, H. J., Stucki, G., & Bickenbach, J. (2020). Covid-19 and post intensive care syndrome: A call for action. Journal of Rehabilitation Medicine, 52(4), 19–22. https://doi.org/10.2340/16501977-2677CrossRef

21.

Langerud, A. K., Rustøen, T., Småstuen, M. C., Kongsgaard, U., & Stubhaug, A. (2018). Health-related quality of life in intensive care survivors: Associations with social support, comorbidity, and pain interference. PLoS ONE, 13(6), 1–13. https://doi.org/10.1371/journal.pone.0199656CrossRef

22.

Koskinen, S., Lundqvist, A., Welfare, N. R.-N. I. for H. and, & 2012, U. (n.d.). Health, functional capacity and welfare in Finland in 2011. Retrieved from https://www.julkari.fi/bitstream/handle/10024/90832/Rap068_2012_netti.pdf?sequence=1&isAllowed=y

23.

Ferguson, N. D., Fan, E., Camporota, L., Antonelli, M., Anzueto, A., Beale, R., & Marco Ranieri, V. (2012). The Berlin definition of ARDS: An expanded rationale, justification, and supplementary material. Intensive Care Medicine, 38(10), 1573–1582. https://doi.org/10.1007/s00134-012-2682-1CrossRefPubMed

24.

Sintonen, H. (2001). The 15D instrument of health-related quality of life: Properties and applications. Annals of Medicine, 33(5), 328–336. https://doi.org/10.3109/07853890109002086CrossRefPubMed

25.

Alanne, S., Roine, R. P., Räsänen, P., Vainiola, T., & Sintonen, H. (2015). Estimating the minimum important change in the 15D scores. Quality of Life Research, 24(3), 599–606. https://doi.org/10.1007/s11136-014-0787-4CrossRefPubMed

26.

de Oliveira, R. P., Teixeira, C., & Rosa, R. G. (2019). Acute respiratory distress syndrome: How do patients fare after the intensive care unit? Revista Brasileira de Terapia Intensiva, 31(4), 555–560. https://doi.org/10.5935/0103-507X.20190074CrossRefPubMedPubMedCentral

27.

Pandharipande, P. P., Girard, T. D., Jackson, J. C., Morandi, A., Thompson, J. L., Pun, B. T., & Ely, E. W. (2013). Long-term cognitive impairment after critical illness. New England Journal of Medicine, 369(14), 1306–1316. https://doi.org/10.1056/NEJMoa1301372CrossRef

28.

Herridge, M. S., Moss, M., Hough, C. L., Hopkins, R. O., Rice, T. W., Bienvenu, O. J., & Azoulay, E. (2016). Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. Intensive Care Medicine, 42(5), 725–738. https://doi.org/10.1007/s00134-016-4321-8CrossRefPubMed

29.

Tibshirani, R., Johnstone, I., Hastie, T., & Efron, B. (2004). Least angle regression. The Annals of Statistics, 32(2), 407–499. https://doi.org/10.1214/009053604000000067CrossRef

30.

Matte-martyn, A., Diaz-granados, N., Al-saidi, F., Cooper, A. B., & Trials, C. (2003). One-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome Margaret. New England Journal of Medicine, 348, 683–693CrossRef

31.

Cohen-Mansfield, Jiska, Dakheel-Ali, Maha, Marx, Marcia S., Thein, Khin, Natalie, G., & Regier, P. (2017). Muscle Weakness and 5-Year Survival in Acute Respiratory Distress Syndrome Survivors. Physiology & behavior, 176(1), 139–148. https://doi.org/10.1016/j.physbeh.2017.03.040CrossRef

32.

Raymond, E., Pisano, E., Gatsonis, C., Boineau, R., Domanski, M., Troutman, C., & Luceri, R. M. (2011). Functional Disability 5 Years after Acute Respiratory Distress Syndrome Margaret. Heart Failure, 364(6), 225–237

33.

Gattinoni, L., Coppola, S., Cressoni, M., Busana, M., Rossi, S., & Chiumello, D. (2020). COVID-19 does not lead to a “typical” acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202003-0817LECrossRefPubMedPubMedCentral

34.

Li, X., & Ma, X. (2020). Acute respiratory failure in COVID-19: Is it “typical” ARDS? Critical Care, 24(1), 1–5. https://doi.org/10.1186/s13054-020-02911-9CrossRef

35.

Brown, S. M., Wilson, E., Presson, A. P., Zhang, C., Dinglas, V. D., Greene, T., & Needham, D. M. (2017). Predictors of 6-month health utility outcomes in survivors of acute respiratory distress syndrome. Thorax, 72(4), 311–317. https://doi.org/10.1136/thoraxjnl-2016-208560CrossRefPubMed

36.

Hopkins, R. O., Weaver, L. K., Chan, K. J., & Orme, J. F. (2004). Quality of life, emotional, and cognitive function following acute respiratory distress syndrome. Journal of the International Neuropsychological Society, 10(7), 1005–1017. https://doi.org/10.1017/S135561770410711XCrossRefPubMed

37.

Schelling, G., Stoll, C., Vogelmeier, C., Hummel, T., Behr, J., Kapfhammer, H. P., & Briegel, J. (2000). Pulmonary function and health-related quality of life in a sample of long-term survivors of the acute respiratory distress syndrome. Intensive Care Medicine, 26(9), 1304–1311. https://doi.org/10.1007/s001340051342CrossRefPubMed

38.

Masclans, J. R., Roca, O., Muñoz, X., Pallisa, E., Torres, F., Rello, J., & Morell, F. (2011). Quality of life, pulmonary function, and tomographic scan abnormalities after ARDS. Chest, 139(6), 1340–1346. https://doi.org/10.1378/chest.10-2438CrossRefPubMed

39.

Hermans, G., & Van den Berghe, G. (2015). Clinical review: Intensive care unit acquired weakness. Critical Care, 19(1), 1–9. https://doi.org/10.1186/s13054-015-0993-7CrossRef

40.

Angel, M. J., Bril, V., Shannon, P., & Herridge, M. S. (2007). Neuromuscular function in survivors of the acute respiratory distress syndrome. Canadian Journal of Neurological Sciences, 34(4), 427–432. https://doi.org/10.1017/S0317167100007307CrossRef

41.

De Jonghe, B., Sharshar, T., Lefaucheur, J. P., Authier, F. J., Durand-Zaleski, I., Boussarsar, M., & Bastuji-Garin, S. (2002). Paresis acquired in the intensive care unit: A prospective multicenter study. Journal of the American Medical Association, 288(22), 2859–2867. https://doi.org/10.1001/jama.288.22.2859CrossRefPubMed

42.

Llano-Diez, M., Renaud, G., Andersson, M., Marrero, H. G., Cacciani, N., Engquist, H., & Larsson, L. (2012). Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading. Critical care (London, England), 16(5), R209. https://doi.org/10.1186/cc11841CrossRefPubMedCentral

43.

Van Aerde, N., Van den Berghe, G., Wilmer, A., Gosselink, R., Hermans, G., Meersseman, P., & Wouters, P. J. (2020). Intensive care unit acquired muscle weakness in COVID-19 patients. Intensive Care Medicine. https://doi.org/10.1007/s00134-020-06244-7CrossRefPubMedPubMedCentral

44.

Li, T. S., Gomersall, C. D., Joynt, G. M., Chan, D. P. S., Leung, P., & Hui, D. S. C. (2006). Long-term outcome of acute respiratory distress syndrome caused by severe acute respiratory syndrome (SARS): an observational study. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 8(4), 302–308

45.

Zhao, Y. Miao., Shang, Y. Min., Song, W. Bin., Li, Q. Quan., Xie, H., Xu, QFu., & Xu, A. Guo. (2020). Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery. EClinicalMedicine. https://doi.org/10.1016/j.eclinm.2020.100463CrossRefPubMedPubMedCentral

46.

Mo, X., Jian, W., Su, Z., Chen, M., Peng, H., Peng, P., & Li, S. (2020). Abnormal pulmonary function in COVID-19 patients at time of hospital discharge. European Respiratory Journal, 55(6), 2–5. https://doi.org/10.1183/13993003.01217-2020CrossRef

47.

Vargas, Maria, Sutherasan, Yuda, Brunetti, Iole, Micalizzi, Camilla, Insorsi, Angelo, Ball, Lorenzo, Folentino, Marta, Sileo, Rosanna, De Lucia, Arduino, Cerana, Manuela, Accattatis, Alessandro, De Lisi, Domenico, Gratarola, Angelo, Mora, Francesco, Peretti, Giorgio, Servillo, Giuseppe, & Pelosi, Paolo. (2018). Mortality and long-term quality of life after percutaneous tracheotomy in Intensive Care Unit: A prospective observational study. Minerva Anestesiologica, 84(9), 1024–1031. https://doi.org/10.23736/S0375-9393.18.12133-XCrossRefPubMed

48.

McGrath, Brendan A., Brenner, Michael J., Warrillow, Stephen J., Pandian, Vinciya, Arora, Asit, Cameron, Tanis S., Añon, José Manuel., Martínez, Gonzalo Hernández, Truog, Robert D., Block, Susan D., Lui, Grace C Y., McDonald, Christine, Rassekh, Christopher H., Atkins, Joshua, Qiang, Li., Vergez, Sébastien., Dulguerov, Pavel, Zenk, Johannes, Antonelli, Massimo, … Feller-Kopman, David J. (2020). Tracheostomy in the COVID-19 era: global and multidisciplinary guidance. The Lancet Respiratory Medicine, 8(7), 717–725. https://doi.org/10.1016/S2213-2600(20)30230-7CrossRefPubMedPubMedCentral

49.

Mattei, A., Amy de la Bretèque, B., Crestani, S., Crevier-Buchman, L., Galant, C., Hans, S., & Giovanni, A. (2020). Guidelines of clinical practice for the management of swallowing disorders and recent dysphonia in the context of the COVID-19 pandemic. European Annals of Otorhinolaryngology, Head and Neck Diseases, 137(3), 173–175. https://doi.org/10.1016/j.anorl.2020.04.011CrossRefPubMedPubMedCentral

50.

Mikkelsen, M. E., Christie, J. D., Lanken, P. N., Biester, R. C., Thompson, B. T., Bellamy, S. L., & Angus, D. C. (2012). The adult respiratory distress syndrome cognitive outcomes study: Long-term neuropsychological function in survivors of acute lung injury. American Journal of Respiratory and Critical Care Medicine, 185(12), 1307–1315. https://doi.org/10.1164/rccm.201111-2025OCCrossRefPubMedPubMedCentral

51.

Helms, J., Kremer, S., Merdji, H., Schenck, M., Severac, F., Clere-Jehl, R., & Meziani, F. (2020). Delirium and encephalopathy in severe COVID-19: A cohort analysis of ICU patients. Critical Care, 24(1), 1–11. https://doi.org/10.1186/s13054-020-03200-1CrossRef

52.

Zhao, H., He, X., Fan, G., Li, L., Huang, Q., Qiu, Q., & Xu, H. (2020). COVID-19 infection outbreak increases anxiety level of general public in China: involved mechanisms and influencing factors. Journal of Affective Disorders, 276(February), 446–452. https://doi.org/10.1016/j.jad.2020.07.085CrossRefPubMedPubMedCentral

53.

Huang, Y., & Zhao, N. (2020). Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: A web-based cross-sectional survey. Psychiatry Research. https://doi.org/10.1016/j.psychres.2020.112954CrossRefPubMedPubMedCentral

54.

Herridge, M. S., Tansey, C. M., Matté, A., Tomlinson, G., Diaz-Granados, N., Cooper, A., & Cheung, A. M. (2011). Functional Disability 5 Years after Acute Respiratory Distress Syndrome. N Engl J Med. https://doi.org/10.1056/NEJMoa1011802CrossRefPubMed

55.

Angus, D. C., Musthafa, A. A., Clermont, G., Griffin, M. F., Linde-Zwirble, W. T., Dremsizov, T. T., & Pinsky, M. R. (2001). Quality-adjusted survival in the first year after the acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 163(6), 1389–1394. https://doi.org/10.1164/ajrccm.163.6.2005123CrossRefPubMed

56.

Briegel, I., Dolch, M., Irlbeck, M., Hauer, D., Kaufmann, I., & Schelling, G. (2013). Ergebnisqualität der Therapie des akuten Lungenversagens: Veränderungen über einen Zeitraum von 2 Jahrzehnten. Der Anaesthesist, 62(4), 261–270. https://doi.org/10.1007/s00101-013-2156-zCrossRefPubMed

57.

Dodoo-Schittko, F., Brandstetter, S., Blecha, S., Thomann-Hackner, K., Brandl, M., Knüttel, H., & Apfelbacher, C. (2017). Determinants of quality of life and return to work following acute respiratory distress syndrome - A systematic review. Deutsches Arzteblatt International, 114(7), 103–109. https://doi.org/10.3238/arztebl.2017.0103CrossRefPubMedPubMedCentral

58.

Edmed, S. L., Sullivan, K. A., Allan, A. C., & Smith, S. S. (2015). Assessment method influences the severity and type of symptoms reported after self-reported mild traumatic brain injury. Journal of Clinical and Experimental Neuropsychology, 37(6), 641–652. https://doi.org/10.1080/13803395.2015.1038984CrossRefPubMed

59.

Gattinoni, L., Chiumello, D., Caironi, P., Busana, M., Romitti, F., Brazzi, L., & Camporota, L. (2020). COVID-19 pneumonia: different respiratory treatments for different phenotypes? Intensive Care Medicine. https://doi.org/10.1007/s00134-020-06033-2CrossRefPubMedPubMedCentral

60.

Gattinoni, L., Chiumello, D., & Rossi, S. (2020). COVID-19 pneumonia: ARDS or not? Critical Care. BioMed Central Ltd. https://doi.org/10.1186/s13054-020-02880-zCrossRef

61.

Hawthorne, G., Richardson, J., & Day, N. A. (2001). A comparison of the Assessment of Quality of Life (AQoL) with four other generic utility instruments. Annals of Medicine, 33, 358–370. https://doi.org/10.3109/07853890109002090CrossRefPubMed

Titel: Quality of life of COVID-19 critically ill survivors after ICU discharge: 90 days follow-up
Auteurs: Lorenzo Gamberini
Carlo Alberto Mazzoli
Harri Sintonen
Davide Colombo
Gaetano Scaramuzzo
Davide Allegri
Tommaso Tonetti
Gianluca Zani
Chiara Capozzi
Emanuela Giampalma
Vanni Agnoletti
Filippo Becherucci
Elisabetta Bertellini
Andrea Castelli
Iacopo Cappellini
Irene Cavalli
Federico Crimaldi
Federica Damiani
Maurizio Fusari
Giovanni Gordini
Cristiana Laici
Maria Concetta Lanza
Mirco Leo
Andrea Marudi
Giuseppe Nardi
Irene Ottaviani
Raffaella Papa
Antonella Potalivo
Vito Marco Ranieri
Emanuele Russo
Stefania Taddei
Carlo Alberto Volta
Savino Spadaro
the ICU-RER COVID-19 Collaboration
Publicatiedatum: 12-05-2021
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 10/2021
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-021-02865-7

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Purpose

Methods

Results

Conclusion

Log in om toegang te krijgen

Andere artikelen Uitgave 10/2021

Measuring capability wellbeing in adults at different stages of life for use in economic evaluation of health and care interventions: a qualitative investigation in people requiring kidney care

Assessing hospitalized patients’ quality of life from external indices: the perspectives of lay people and health professionals

Australian adolescent population norms for the child health utility index 9D—results from the young minds matter survey

Correction to: Health-related quality of life in adults with tetralogy of Fallot repair: a systematic review and meta-analysis

Health-related quality of life outcomes and influencing factors in patients with unruptured intracranial aneurysms after endovascular treatment

Validity, responsiveness and minimal important change of the EQ-5D-5L in patients after rotator cuff repair, shoulder arthroplasty or thumb carpometacarpal arthroplasty