Skip to main content
Top
Gepubliceerd in: Quality of Life Research 5/2022

16-10-2021

Quality of life in adults with autism spectrum disorder: influence of age, sex, and a controlled, randomized mindfulness-based stress reduction pilot intervention

Auteurs: B. Blair Braden, Broc A. Pagni, Leanna Monahan, Melissa J. M. Walsh, Maria V. Dixon, Shanna Delaney, Lisa Ballard, John E. Ware Jr.

Gepubliceerd in: Quality of Life Research | Uitgave 5/2022

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Purpose

Adults with autism spectrum disorder (ASD) consistently report worse functional health and well-being, compared to neurotypical (NT) peers. In a series of studies, we aimed to elucidated the effects of sex, age, and their interaction on health-related quality of life (HRQoL) and evaluated the effectiveness of mindfulness-based stress reduction (MBSR) for improving health-, disability-, and autism-related QoL, with possible sex and age outcome moderators, in adults with ASD.

Methods

Study 1 used the 36-Item Short Form Survey to compare mental and physical HRQoL composite scores in adults with ASD (n = 67) and matched NT adults (n = 66). Study 2 was a randomized pilot evaluation of the effect of MBSR, compared to an active control intervention with social support and relaxation education (support/education; n = 56), on the World Health Organization QoL BREF, Disability, and Autism-Specific scales in adults with ASD.

Results

In Study 1, we replicated findings that mental HRQoL is worse in both men and women with ASD, compared to NT counterparts, but physical HRQoL is only worse in women with ASD. We present novel findings that older age is associated with better mental HRQoL in women with ASD only. In Study 2, MBSR improved disability-related QoL in adults with ASD over and above the support/education intervention, but both interventions improved mental HRQoL. Lastly, both interventions were more effective for HRQoL improvements in women with ASD.

Conclusion

Findings encourage precision medicine approaches tailored to age and sex groups for best HRQoL outcomes in adults with ASD.
ClinicalTrials.gov Identifier: NCT04017793.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
5.
go back to reference Schmidt, L., Kirchner, J., Strunz, S., Broźus, J., Ritter, K., Roepke, S., & Dziobek, I. (2015). Psychosocial functioning and life satisfaction in adults with autism spectrum disorder without intellectual impairment. Journal of Clinical Psychology, 71(12), 1259–1268. https://doi.org/10.1002/jclp.22225CrossRefPubMed Schmidt, L., Kirchner, J., Strunz, S., Broźus, J., Ritter, K., Roepke, S., & Dziobek, I. (2015). Psychosocial functioning and life satisfaction in adults with autism spectrum disorder without intellectual impairment. Journal of Clinical Psychology, 71(12), 1259–1268. https://​doi.​org/​10.​1002/​jclp.​22225CrossRefPubMed
10.
go back to reference Graham Holmes, L., Zampella, C. J., Clements, C., McCleery, J. P., Maddox, B. B., Parish-Morris, J., Udhnani, M. D., Schultz, R. T., & Miller, J. S. (2020). A lifespan approach to patient-reported outcomes and quality of life for people on the autism spectrum. Autism Research. https://doi.org/10.1002/aur.2275CrossRefPubMed Graham Holmes, L., Zampella, C. J., Clements, C., McCleery, J. P., Maddox, B. B., Parish-Morris, J., Udhnani, M. D., Schultz, R. T., & Miller, J. S. (2020). A lifespan approach to patient-reported outcomes and quality of life for people on the autism spectrum. Autism Research. https://​doi.​org/​10.​1002/​aur.​2275CrossRefPubMed
12.
go back to reference Ware, J. E., & Kosinski, M. (2001). SF-36 Physical & Mental Health Summary Scales: A manual for users of version 1 (2nd ed.). Quality Metric. Ware, J. E., & Kosinski, M. (2001). SF-36 Physical & Mental Health Summary Scales: A manual for users of version 1 (2nd ed.). Quality Metric.
24.
go back to reference Pagni, B. A., Walsh, M. J. M., Foldes, E., Sebren, A., Dixon, M. V., Guerithault, N., & Braden, B. B. (2020). The neural correlates of mindfulness-induced depression reduction in adults with autism spectrum disorder: A pilot study. Journal of Neuroscience Research, 98(6), 1150–1161. https://doi.org/10.1002/jnr.24600CrossRefPubMed Pagni, B. A., Walsh, M. J. M., Foldes, E., Sebren, A., Dixon, M. V., Guerithault, N., & Braden, B. B. (2020). The neural correlates of mindfulness-induced depression reduction in adults with autism spectrum disorder: A pilot study. Journal of Neuroscience Research, 98(6), 1150–1161. https://​doi.​org/​10.​1002/​jnr.​24600CrossRefPubMed
25.
go back to reference Pagni, B. A., Walsh, M. J. M., Rogers, C., & Braden, B. B. (2020). Social cognition in autism spectrum disorder across the adult lifespan: Influence of age and sex on reading the mind in the eyes task in a cross-sectional sample. Frontiers in Integrative Neuroscience, 14(September), 1–8. https://doi.org/10.3389/fnint.2020.571408CrossRef Pagni, B. A., Walsh, M. J. M., Rogers, C., & Braden, B. B. (2020). Social cognition in autism spectrum disorder across the adult lifespan: Influence of age and sex on reading the mind in the eyes task in a cross-sectional sample. Frontiers in Integrative Neuroscience, 14(September), 1–8. https://​doi.​org/​10.​3389/​fnint.​2020.​571408CrossRef
29.
34.
go back to reference Lord, C., Rutter, M., DiLavore, P., Risi, S., Gotham, K., & Bishop, S. (2012). Autism Diagnostic Observation Schedule–(ADOS-2) (2nd ed.). Los Angeles, CA: Western Psychological Corporation. Lord, C., Rutter, M., DiLavore, P., Risi, S., Gotham, K., & Bishop, S. (2012). Autism Diagnostic Observation Schedule–(ADOS-2) (2nd ed.). Los Angeles, CA: Western Psychological Corporation.
35.
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Association. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Association.
36.
go back to reference Constantino, J. N. (2012). Social Responsiveness Scale (2nd ed.). Western Psychological Services. Constantino, J. N. (2012). Social Responsiveness Scale (2nd ed.). Western Psychological Services.
37.
go back to reference Kaufman, A. S., & Kaufman, N. L. (2004). KBIT-2: Kaufman brief intelligence test (2nd ed.). Pearson Education, Inc. Kaufman, A. S., & Kaufman, N. L. (2004). KBIT-2: Kaufman brief intelligence test (2nd ed.). Pearson Education, Inc.
44.
go back to reference Üstün, T. B. (2010). Measuring health and disability: Manual for WHO Disability Assessment Schedule WHODAS 2.0. World Health Organization. Üstün, T. B. (2010). Measuring health and disability: Manual for WHO Disability Assessment Schedule WHODAS 2.0. World Health Organization.
45.
go back to reference Braden, B. B., Pipe, T. B., Smith, R., Glaspy, T. K., Deatherage, B. R., & Baxter, L. C. (2016). Brain and behavior changes associated with an abbreviated 4-week mindfulness-based stress reduction course in back pain patients. Brain and Behavior, 6(3), 1–13. https://doi.org/10.1002/brb3.443CrossRef Braden, B. B., Pipe, T. B., Smith, R., Glaspy, T. K., Deatherage, B. R., & Baxter, L. C. (2016). Brain and behavior changes associated with an abbreviated 4-week mindfulness-based stress reduction course in back pain patients. Brain and Behavior, 6(3), 1–13. https://​doi.​org/​10.​1002/​brb3.​443CrossRef
46.
48.
go back to reference Skevington, S. M., & McCrate, F. M. (2012). Expecting a good quality of life in health: assessing people with diversediseases and conditions using the WHOQOL-BREF. Health Expectations, 15, 49–62.CrossRef Skevington, S. M., & McCrate, F. M. (2012). Expecting a good quality of life in health: assessing people with diversediseases and conditions using the WHOQOL-BREF. Health Expectations, 15, 49–62.CrossRef
49.
56.
go back to reference Burnett-Zeigler, I., Hong, S., Waldron, E. M., Maletich, C., Yang, A., & Moskowitz, J. (2019). A mindfulness-based intervention for low-income African American women with depressive symptoms delivered by an experienced instructor versus a novice instructor. Journal of Alternative and Complementary Medicine, 25(7), 699–708. https://doi.org/10.1089/acm.2018.0393CrossRefPubMed Burnett-Zeigler, I., Hong, S., Waldron, E. M., Maletich, C., Yang, A., & Moskowitz, J. (2019). A mindfulness-based intervention for low-income African American women with depressive symptoms delivered by an experienced instructor versus a novice instructor. Journal of Alternative and Complementary Medicine, 25(7), 699–708. https://​doi.​org/​10.​1089/​acm.​2018.​0393CrossRefPubMed
58.
go back to reference Brooks, J. M., Muller, V., Sánchez, J., et al. (2019). Mindfulness as aprotective factor against depressive symptoms in people withfibromyalgia. Journal of Mental Health, 22, 1–7. Brooks, J. M., Muller, V., Sánchez, J., et al. (2019). Mindfulness as aprotective factor against depressive symptoms in people withfibromyalgia. Journal of Mental Health, 22, 1–7.
59.
go back to reference Meyer, E. C., Frankfurt, S. B., Kimbrel, N. A., DeBeer, B. B., Gulliver, S. B., & Morrisette, S. B. (2018). Theinfluence of mindfulness, self-compassion, psychological flexibility, and posttraumatic stress disorder on disabilityand quality of life over time in war veterans. Journal of Clinical Psychology, 74(7), 1272–1280. https://doi.org/10.1002/jclp.22596CrossRefPubMed Meyer, E. C., Frankfurt, S. B., Kimbrel, N. A., DeBeer, B. B., Gulliver, S. B., & Morrisette, S. B. (2018). Theinfluence of mindfulness, self-compassion, psychological flexibility, and posttraumatic stress disorder on disabilityand quality of life over time in war veterans. Journal of Clinical Psychology, 74(7), 1272–1280. https://​doi.​org/​10.​1002/​jclp.​22596CrossRefPubMed
60.
go back to reference Vibe, M., Bjørndal, A., Fattah, S., Dyrdal, G. M., Halland, E., & Tanner-Smith, E. E. (2017). Mindfulness-based stress reduction (MBSR) for improving health, quality of life and social functioning in adults: A systematic review and meta-analysis. Campbell Systematic Reviews. https://doi.org/10.4073/csr.2017.11CrossRef Vibe, M., Bjørndal, A., Fattah, S., Dyrdal, G. M., Halland, E., & Tanner-Smith, E. E. (2017). Mindfulness-based stress reduction (MBSR) for improving health, quality of life and social functioning in adults: A systematic review and meta-analysis. Campbell Systematic Reviews. https://​doi.​org/​10.​4073/​csr.​2017.​11CrossRef
Metagegevens
Titel
Quality of life in adults with autism spectrum disorder: influence of age, sex, and a controlled, randomized mindfulness-based stress reduction pilot intervention
Auteurs
B. Blair Braden
Broc A. Pagni
Leanna Monahan
Melissa J. M. Walsh
Maria V. Dixon
Shanna Delaney
Lisa Ballard
John E. Ware Jr.
Publicatiedatum
16-10-2021
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 5/2022
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-021-03013-x

Andere artikelen Uitgave 5/2022

Quality of Life Research 5/2022 Naar de uitgave