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Quality of Life Research

Gepubliceerd in:

01-05-2007 | Brief Communication

Quality of life findings from a multicenter, multinational, observational study of patients with metastatic hormone-refractory prostate cancer

Auteurs: Patrick W. Sullivan, Parvez M. Mulani, Mayer Fishman, Darryl Sleep

Gepubliceerd in: Quality of Life Research | Uitgave 4/2007

Abstract

Background

The assessment of health-related quality of life (HRQL) for patients with hormone-refractory prostate cancer (HRPC) is of paramount importance because new treatments have a modest impact on survival but side effects of treatment and disease symptoms can significantly impact HRQL.

Methods

This was an observational, non-interventional, multi-center, multi-national cohort study of patients with metastatic HRPC. Health-related quality of life was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ C30), the Functional Assessment of Cancer Therapy-Prostate (FACT-P) and the EQ-5D index. Mean changes from baseline to month 3, 6, and 9 were computed and tested using paired t-tests.

Results

FACT-P PCS, EQ-5D index and 10 of 14 EORTC domains were statistically significantly lower (P < 0.05) than the baseline scores at the 3, 6 and 9 month visits. The domains that did not reach statistical significance were cognitive functioning, insomnia, diarrhea and financial difficulties.

Conclusions

These data demonstrate that patients with metastatic HRPC experience rapid, significant deterioration in HRQL, highlighting the need for effective palliative therapy for men with HRPC.

vorige artikel Factors affecting health-related quality of life in women with recurrent breast cancer in Korea

volgende artikel Health-related quality of life in HIV-1-infected patients on HAART: a five-years longitudinal analysis accounting for dropout in the APROCO-COPILOTE cohort (ANRS CO-8)

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Titel: Quality of life findings from a multicenter, multinational, observational study of patients with metastatic hormone-refractory prostate cancer
Auteurs: Patrick W. Sullivan
Parvez M. Mulani
Mayer Fishman
Darryl Sleep
Publicatiedatum: 01-05-2007
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 4/2007
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-006-9156-2

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Abstract

Background

Methods

Results

Conclusions

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