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Gepubliceerd in: Quality of Life Research 6/2008

01-08-2008

Quality of life as a prognostic factor of overall survival in patients with advanced hepatocellular carcinoma: results from two French clinical trials

Auteurs: Franck Bonnetain, Xavier Paoletti, Sandra Collette, Michel Doffoel, Olivia Bouché, Jean Luc Raoul, Philippe Rougier, Fadil Masskouri, Jean Claude Barbare, Laurent Bedenne

Gepubliceerd in: Quality of Life Research | Uitgave 6/2008

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Abstract

Aim

The aims of our study were to assess quality of life (QoL) as a prognostic factor of overall survival (OS) and to determine whether QoL data improved three prognostic classifications among French patients with advanced hepatocellular carcinoma (HCC).

Results

Among 538 included patients, QoL at baseline was available for 489 patients (90%). Longer median OS was significantly associated with higher Spitzer scores at baseline, ranging from 2.17 months (Spitzer = 3) to 8.93 months (Spitzer = 10). Variables retained in the multivariate Cox model were: jaundice, hepatomegaly, hepatalgia, portal thrombosis, alphafetoprotein, bilirubin, albumin, small HCC, and Spitzer QoL Index (hazard ratio = 0.84 95% CI [0.79–0.90]). According to Harrell’s C-index, QoL was the best prognostic variable to add. CLIP plus the Spitzer QoL Index had the most discriminating value (C = 0.71).

Conclusions

Our results suggest that QoL is an independent prognostic factor for survival in HCC patients with mainly alcoholic cirrhosis. The prognostic value of CLIP score could be improved by adding Spitzer QOL Index scores.
Literatuur
1.
go back to reference Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2001). Estimating the world cancer burden. GLOBOCAN 2000. International Journal of Cancer, 94, 153–156. doi: 10.​1002/​ijc.​1440.​ Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2001). Estimating the world cancer burden. GLOBOCAN 2000. International Journal of Cancer, 94, 153–156. doi: 10.​1002/​ijc.​1440.​
2.
go back to reference El-Serag, H. B., Davila, J. A., Petersen, N. J., & McGlynn, K. A. (2003). The continuing increase in the incidence of hepatocellular carcinoma in the United States - An update. Annals of Internal Medicine, 139, 817–823. PubMed El-Serag, H. B., Davila, J. A., Petersen, N. J., & McGlynn, K. A. (2003). The continuing increase in the incidence of hepatocellular carcinoma in the United States - An update. Annals of Internal Medicine, 139, 817–823. PubMed
3.
go back to reference Remontet, L., Esteve, J., Bouvier, A. M., et al. (2003). Cancer incidence and mortality in France over the period 1978–2000. Revue d’Epidemiologie et de Sante Publique, 51, 3–30. PubMed Remontet, L., Esteve, J., Bouvier, A. M., et al. (2003). Cancer incidence and mortality in France over the period 1978–2000. Revue d’Epidemiologie et de Sante Publique, 51, 3–30. PubMed
5.
go back to reference Garcia, S. F., Cella, D., Clauser, S., et al. (1995). Editorial. Quality of life and clinical trials. Lancet, 346, 1–2. Garcia, S. F., Cella, D., Clauser, S., et al. (1995). Editorial. Quality of life and clinical trials. Lancet, 346, 1–2.
6.
go back to reference Beitz, J., Gnecco, C., & Justice, R. (1996). Quality-of-life end points in cancer clinical trials: The U.S. Food and drug administration perspective. Journal of the National Cancer Institute. Monographs, 20, 7–9. PubMed Beitz, J., Gnecco, C., & Justice, R. (1996). Quality-of-life end points in cancer clinical trials: The U.S. Food and drug administration perspective. Journal of the National Cancer Institute. Monographs, 20, 7–9. PubMed
7.
go back to reference Johnson, J. R., & Temple, R. (1985). Food and drug administration requirements for approval of new anticancer drugs. Cancer Treatment Reports, 69, 1155–1159. PubMed Johnson, J. R., & Temple, R. (1985). Food and drug administration requirements for approval of new anticancer drugs. Cancer Treatment Reports, 69, 1155–1159. PubMed
9.
go back to reference Dancey, J., Zee, B., Osoba, D., et al. (1997). Quality of life scores: An independent prognostic variable in a general population of cancer patients receiving chemotherapy. The National Cancer Institute of Canada Clinical trials Group. Quality of Life Research, 6, 151–158. doi: 10.​1023/​A:​1026442201191.​ Dancey, J., Zee, B., Osoba, D., et al. (1997). Quality of life scores: An independent prognostic variable in a general population of cancer patients receiving chemotherapy. The National Cancer Institute of Canada Clinical trials Group. Quality of Life Research, 6, 151–158. doi: 10.​1023/​A:​1026442201191.​
10.
go back to reference Okuda, K., Ohtsuki, T., Obata, H., et al. (1985). Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer, 56, 918–928. 10.1002/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E. Okuda, K., Ohtsuki, T., Obata, H., et al. (1985). Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer, 56, 918–928. 10.1002/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E.
11.
go back to reference The Cancer of Liver Italian Program Investigators. (1998). A new prognostic system for hepatocellular carcinoma: A retrospective study of 435 patients: The Cancer of the Liver Italian Program (CLIP) investigators. Hepatology (Baltimore, Md.), 28, 751–755. doi: 10.​1002/​hep.​510280322.​ The Cancer of Liver Italian Program Investigators. (1998). A new prognostic system for hepatocellular carcinoma: A retrospective study of 435 patients: The Cancer of the Liver Italian Program (CLIP) investigators. Hepatology (Baltimore, Md.), 28, 751–755. doi: 10.​1002/​hep.​510280322.​
12.
go back to reference Llovet, J. M., Bru, C., & Bruix, J. (1999). Prognosis of hepatocellular carcinoma: The BCLC staging classification. Seminars in Liver Disease, 19, 329–338. PubMedCrossRef Llovet, J. M., Bru, C., & Bruix, J. (1999). Prognosis of hepatocellular carcinoma: The BCLC staging classification. Seminars in Liver Disease, 19, 329–338. PubMedCrossRef
13.
go back to reference Chevret, S., Trinchet, J. C., Mathieu, D., et al. (1999). A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. Groupe d’Etude et de Traitement du Carcinome Hepatocellulaire. Journal of Hepatology, 31, 133–141. doi: 10.​1016/​S0168-8278(99)80173-1.​ Chevret, S., Trinchet, J. C., Mathieu, D., et al. (1999). A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. Groupe d’Etude et de Traitement du Carcinome Hepatocellulaire. Journal of Hepatology, 31, 133–141. doi: 10.​1016/​S0168-8278(99)80173-1.​
14.
go back to reference Ueno, S., Tanabe, G., Sako, K., et al. (2001). Discrimination value of the new western prognostic system (CLIP score) for hepatocellular carcinoma in 662 Japanese patients. Cancer of Liver Italian Program. Hepatology (Baltimore, Md.), 34, 529–534. doi: 10.​1053/​jhep.​2001.​27219.​ Ueno, S., Tanabe, G., Sako, K., et al. (2001). Discrimination value of the new western prognostic system (CLIP score) for hepatocellular carcinoma in 662 Japanese patients. Cancer of Liver Italian Program. Hepatology (Baltimore, Md.), 34, 529–534. doi: 10.​1053/​jhep.​2001.​27219.​
15.
16.
go back to reference The Cancer of Liver Italian Program Investigators. (2000). Prospective validation of the CLIP score: A new prognostic system for patients with cirrhosis and hepatocellular carcinoma. Hepatology (Baltimore, Md.), 31, 840–845. doi: 10.​1053/​he.​2000.​5628.​ The Cancer of Liver Italian Program Investigators. (2000). Prospective validation of the CLIP score: A new prognostic system for patients with cirrhosis and hepatocellular carcinoma. Hepatology (Baltimore, Md.), 31, 840–845. doi: 10.​1053/​he.​2000.​5628.​
17.
go back to reference Levy, I., Sherman, M., & The Liver Cancer Study Group of the University of Toronto (2002). Staging of hepatocellular carcinoma: Assessment of the CLIP, Okuda, and Child-Pugh staging systems in a cohort of 257 patients in Toronto. Gut, 50, 881–885. doi: 10.​1136/​gut.​50.​6.​881.​ Levy, I., Sherman, M., & The Liver Cancer Study Group of the University of Toronto (2002). Staging of hepatocellular carcinoma: Assessment of the CLIP, Okuda, and Child-Pugh staging systems in a cohort of 257 patients in Toronto. Gut, 50, 881–885. doi: 10.​1136/​gut.​50.​6.​881.​
18.
go back to reference Wildi, S., Pestalozzi, B. C., McCormack, L., & Clavien, P. A. (2004). Critical evaluation of the different staging systems for hepatocellular carcinoma. British Journal of Surgery, 91, 400–408. doi: 10.​1002/​bjs.​4554.​ Wildi, S., Pestalozzi, B. C., McCormack, L., & Clavien, P. A. (2004). Critical evaluation of the different staging systems for hepatocellular carcinoma. British Journal of Surgery, 91, 400–408. doi: 10.​1002/​bjs.​4554.​
19.
go back to reference Farinati, F., Rinaldi, M., Gianni, S., & Naccarato, R. (2000). How should patients with hepatocellular carcinoma be staged? Validation of a new prognostic system. Cancer, 89, 2266–2273. doi :10.1002/1097-0142(20001201)89:11<2266::AID-CNCR15>3.0.CO;2-0. Farinati, F., Rinaldi, M., Gianni, S., & Naccarato, R. (2000). How should patients with hepatocellular carcinoma be staged? Validation of a new prognostic system. Cancer, 89, 2266–2273. doi :10.1002/1097-0142(20001201)89:11<2266::AID-CNCR15>3.0.CO;2-0.
20.
go back to reference Marrero, J. A., Fontana, R. J., Barrat, A., et al. (2005). Prognosis of hepatocellular carcinoma: Comparison of 7 staging systems in an American cohort. Hepatology (Baltimore, Md.), 41, 707–716. doi: 10.​1002/​hep.​20636.​ Marrero, J. A., Fontana, R. J., Barrat, A., et al. (2005). Prognosis of hepatocellular carcinoma: Comparison of 7 staging systems in an American cohort. Hepatology (Baltimore, Md.), 41, 707–716. doi: 10.​1002/​hep.​20636.​
21.
go back to reference Leung, T. W., Tang, A. M., Zee, B., et al. (2002). Construction of the Chinese university prognostic index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the cancer of the liver Italian program staging system: A study based on 926 patients. Cancer, 94, 1760–1769. doi: 10.​1002/​cncr.​10384.​ Leung, T. W., Tang, A. M., Zee, B., et al. (2002). Construction of the Chinese university prognostic index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the cancer of the liver Italian program staging system: A study based on 926 patients. Cancer, 94, 1760–1769. doi: 10.​1002/​cncr.​10384.​
24.
go back to reference Doffoël, M., Bonnetain, F., Bouché, O., et al. (2008). Multicentre randomised phase III trial comparing tamoxifen alone or with transarterial lipiodol chemoembolisation for unresectable hepatocellular carcinoma in cirrhotic patients (Fédération Francophone de Cancérologie Digestive 9402). European Journal of Cancer, 44, 528–538. PubMedCrossRef Doffoël, M., Bonnetain, F., Bouché, O., et al. (2008). Multicentre randomised phase III trial comparing tamoxifen alone or with transarterial lipiodol chemoembolisation for unresectable hepatocellular carcinoma in cirrhotic patients (Fédération Francophone de Cancérologie Digestive 9402). European Journal of Cancer, 44, 528–538. PubMedCrossRef
25.
go back to reference Spitzer, W. O., Dobson, A. J., Hall, J., et al. (1981). Measuring the quality of life of cancer patients. A concise QL-Index for use by physician. Journal of Chronic Diseases, 34, 585–597. doi: 10.​1016/​0021-9681(81)90058-8.​ Spitzer, W. O., Dobson, A. J., Hall, J., et al. (1981). Measuring the quality of life of cancer patients. A concise QL-Index for use by physician. Journal of Chronic Diseases, 34, 585–597. doi: 10.​1016/​0021-9681(81)90058-8.​
26.
go back to reference Anderson, R. T., Aaronson, N. K., & Wilkin, D. (1993). Critical review of the international assessments of heath-related quality of life. Quality of Life Research, 2, 369–395. doi: 10.​1007/​BF00422215.​ Anderson, R. T., Aaronson, N. K., & Wilkin, D. (1993). Critical review of the international assessments of heath-related quality of life. Quality of Life Research, 2, 369–395. doi: 10.​1007/​BF00422215.​
27.
go back to reference Sloan, J. A., Loprinzi, C. L., Kuross, S. A., et al. (1998). Randomized comparison of four tools measuring overall quality of life in patients with advanced cancer. Journal of Clinical Oncology, 16, 3662–3673. PubMed Sloan, J. A., Loprinzi, C. L., Kuross, S. A., et al. (1998). Randomized comparison of four tools measuring overall quality of life in patients with advanced cancer. Journal of Clinical Oncology, 16, 3662–3673. PubMed
28.
go back to reference Mazzaferro, V., Regalia, E., Doci, R., et al. (1996). Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. New England Journal of Medicine, 334, 693–699. PubMedCrossRef Mazzaferro, V., Regalia, E., Doci, R., et al. (1996). Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. New England Journal of Medicine, 334, 693–699. PubMedCrossRef
29.
go back to reference Harrell, F. E., Lee, K. L., & Mark, D. B. (1996). Tutorial in biostatistics. Multivariable prognostic models issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Statistics in Medicine, 15, 361–387. PubMedCrossRef Harrell, F. E., Lee, K. L., & Mark, D. B. (1996). Tutorial in biostatistics. Multivariable prognostic models issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Statistics in Medicine, 15, 361–387. PubMedCrossRef
30.
go back to reference Ringdal, G. I., Ringdal, K., Kvinnsland, S., et al. (1994). Quality of life of cancer patients with different prognosis. Quality of Life Research, 3, 143–154. PubMedCrossRef Ringdal, G. I., Ringdal, K., Kvinnsland, S., et al. (1994). Quality of life of cancer patients with different prognosis. Quality of Life Research, 3, 143–154. PubMedCrossRef
31.
go back to reference Ringdal, G. I., Gotestam, K. G., Kaasa, S., et al. (1996). Prognostic factors and survival in a heterogeneous sample of cancer patients. British Journal of Cancer, 73, 1594–1599. PubMed Ringdal, G. I., Gotestam, K. G., Kaasa, S., et al. (1996). Prognostic factors and survival in a heterogeneous sample of cancer patients. British Journal of Cancer, 73, 1594–1599. PubMed
32.
go back to reference Coates, A., Porzsolt, F., & Osoba, D. (1997). Quality of life in oncology practice: Prognostic value of EORTC QLQ-C30 scores in patients with advanced malignancy. European Journal of Cancer, 33, 1025–1030. PubMedCrossRef Coates, A., Porzsolt, F., & Osoba, D. (1997). Quality of life in oncology practice: Prognostic value of EORTC QLQ-C30 scores in patients with advanced malignancy. European Journal of Cancer, 33, 1025–1030. PubMedCrossRef
33.
go back to reference Coates, A., Forbes, J., & Simes, R. J. (1993). Prognostic value of performance status and quality of life scores during chemotherapy for advanced breast cancer. The Australian New Zealand Breast Cancer Trials Group. Journal of Clinical Oncology, 11, 2050–2051. PubMed Coates, A., Forbes, J., & Simes, R. J. (1993). Prognostic value of performance status and quality of life scores during chemotherapy for advanced breast cancer. The Australian New Zealand Breast Cancer Trials Group. Journal of Clinical Oncology, 11, 2050–2051. PubMed
34.
go back to reference Kramer, J. A., Curran, D., Piccart, M., et al. (2000). Identification and interpretation of clinical and quality of life prognostic factors for survival and response to treatment in first-line chemotherapy in advanced breast cancer. European Journal of Cancer, 36, 1498–1506. PubMedCrossRef Kramer, J. A., Curran, D., Piccart, M., et al. (2000). Identification and interpretation of clinical and quality of life prognostic factors for survival and response to treatment in first-line chemotherapy in advanced breast cancer. European Journal of Cancer, 36, 1498–1506. PubMedCrossRef
35.
go back to reference Efficace, F., Biganzoli, L., Piccart, M., et al. (2004). Baseline health-related quality of life data as prognostic factors in a phase III multicentre study of women with metastatic breast cancer. European Journal of Cancer, 40, 1021–1030. PubMedCrossRef Efficace, F., Biganzoli, L., Piccart, M., et al. (2004). Baseline health-related quality of life data as prognostic factors in a phase III multicentre study of women with metastatic breast cancer. European Journal of Cancer, 40, 1021–1030. PubMedCrossRef
36.
go back to reference Langendijk, H., Aaronson, N. K., de Jong, J. M. A., et al. (2000). The prognostic impact of quality of life assessed with the EORTC QLQ-C30 in inoperable non-small cell lung carcinoma treated with radiotherapy. Radiotherapy and Oncology, 55, 19–25. PubMedCrossRef Langendijk, H., Aaronson, N. K., de Jong, J. M. A., et al. (2000). The prognostic impact of quality of life assessed with the EORTC QLQ-C30 in inoperable non-small cell lung carcinoma treated with radiotherapy. Radiotherapy and Oncology, 55, 19–25. PubMedCrossRef
37.
go back to reference Montazeri, A., Milroy, R., Hole, D., et al. (2001). Quality of life in lung cancer patients as an important prognostic factor. Lung Cancer, 31, 233–240. PubMedCrossRef Montazeri, A., Milroy, R., Hole, D., et al. (2001). Quality of life in lung cancer patients as an important prognostic factor. Lung Cancer, 31, 233–240. PubMedCrossRef
38.
go back to reference Herndon, J. E., Fleishman, S., Kornblith, A. N., et al. (1999). Is quality of life predictive of the survival of patients with advanced non small cell lung carcinoma? Cancer, 85, 333–340. PubMedCrossRef Herndon, J. E., Fleishman, S., Kornblith, A. N., et al. (1999). Is quality of life predictive of the survival of patients with advanced non small cell lung carcinoma? Cancer, 85, 333–340. PubMedCrossRef
39.
go back to reference Dharma-Wardene, M., Au, H. J., Hanson, J., et al. (2004). Baseline FACT-G score is a predictor of survival for advanced lung cancer. Quality of Life Reseach, 13, 1209–1216. CrossRef Dharma-Wardene, M., Au, H. J., Hanson, J., et al. (2004). Baseline FACT-G score is a predictor of survival for advanced lung cancer. Quality of Life Reseach, 13, 1209–1216. CrossRef
40.
go back to reference Blazeby, J. M., Brookes, S. T., & Alderson, D. (2001). The prognostic value of quality of life scores during treatment for oesophageal cancer. Gut, 49, 227–230. PubMedCrossRef Blazeby, J. M., Brookes, S. T., & Alderson, D. (2001). The prognostic value of quality of life scores during treatment for oesophageal cancer. Gut, 49, 227–230. PubMedCrossRef
41.
go back to reference Fang, F. M., Tsai, W. L., Chiu, H., et al. (2004). Quality of life as a survival predictor for esophageal squamous cell carcinoma treated with radiotherapy. International Journal of Radiation, Biology, Physics, 58, 1394–1404. CrossRef Fang, F. M., Tsai, W. L., Chiu, H., et al. (2004). Quality of life as a survival predictor for esophageal squamous cell carcinoma treated with radiotherapy. International Journal of Radiation, Biology, Physics, 58, 1394–1404. CrossRef
42.
go back to reference Chau, I., Norman, A. R., Cunningham, D., et al. (2004). Multivariate prognostic factor analysis in locally advanced and metastatic esophago-gastric cancer-pooled analysis from three multicenter, randomized, controlled trails using individual patients data. Journal of Clinical Oncology, 22, 2395–2403. PubMedCrossRef Chau, I., Norman, A. R., Cunningham, D., et al. (2004). Multivariate prognostic factor analysis in locally advanced and metastatic esophago-gastric cancer-pooled analysis from three multicenter, randomized, controlled trails using individual patients data. Journal of Clinical Oncology, 22, 2395–2403. PubMedCrossRef
43.
go back to reference de Graeff, A., de Leeuw, J. R. J., Ros, W. J. G., et al. (2001). Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer. European Journal of Cancer, 37, 332–339. PubMedCrossRef de Graeff, A., de Leeuw, J. R. J., Ros, W. J. G., et al. (2001). Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer. European Journal of Cancer, 37, 332–339. PubMedCrossRef
44.
go back to reference Ramsey, S. D., Anderson, M. R., Etzioni, R., et al. (2000). Quality of life in survivors of colorectal carcinoma. Cancer, 39, 1294–1303. CrossRef Ramsey, S. D., Anderson, M. R., Etzioni, R., et al. (2000). Quality of life in survivors of colorectal carcinoma. Cancer, 39, 1294–1303. CrossRef
45.
go back to reference Coates, A., Thomson, D., McLeod, G. R., et al. (1993). Prognostic value of quality of life scores in a trial of chemotherapy with or without interferon in patients with metastatic malignant melanoma. European Journal of Cancer, 29A, 1731–1734. CrossRef Coates, A., Thomson, D., McLeod, G. R., et al. (1993). Prognostic value of quality of life scores in a trial of chemotherapy with or without interferon in patients with metastatic malignant melanoma. European Journal of Cancer, 29A, 1731–1734. CrossRef
46.
go back to reference Wisloff, F., Hjorth, M., et al., for the Nordic Myeloma Study Group. (1997). Health-related quality of life assessed before and during chemotherapy predicts for survival in multiple myeloma. British Journal of Haematology, 97, 29–37. Wisloff, F., Hjorth, M., et al., for the Nordic Myeloma Study Group. (1997). Health-related quality of life assessed before and during chemotherapy predicts for survival in multiple myeloma. British Journal of Haematology, 97, 29–37.
47.
go back to reference Kornblith, A. B., Thaler, H. T., Wong, G., et al. (1995). Quality of life of women with ovarian cancer. Gynecologic oncology, 59, 231–242. PubMedCrossRef Kornblith, A. B., Thaler, H. T., Wong, G., et al. (1995). Quality of life of women with ovarian cancer. Gynecologic oncology, 59, 231–242. PubMedCrossRef
48.
go back to reference Langendijk, H., Aaronson, N. K., ten Velde, G. P., et al. (1999). Pretreatment quality of life in patients with gIioblastoma multiforme. Oncology Nursing Forum, 26, 921–925. Langendijk, H., Aaronson, N. K., ten Velde, G. P., et al. (1999). Pretreatment quality of life in patients with gIioblastoma multiforme. Oncology Nursing Forum, 26, 921–925.
49.
go back to reference Yeo, W., Mo, F. K., Koh, J., et al. (2006). Quality of life is predictive of survival in patients with unresectable hepatocellular carcinoma. Annals of Oncology, 17, 1083–1089. PubMedCrossRef Yeo, W., Mo, F. K., Koh, J., et al. (2006). Quality of life is predictive of survival in patients with unresectable hepatocellular carcinoma. Annals of Oncology, 17, 1083–1089. PubMedCrossRef
50.
go back to reference Altman, D., & Royston, P. (2000). What do we mean by validating a prognostic model? Statistics in Medicine, 19, 453–473. PubMedCrossRef Altman, D., & Royston, P. (2000). What do we mean by validating a prognostic model? Statistics in Medicine, 19, 453–473. PubMedCrossRef
51.
go back to reference Barbare, J. C., Bouché, O., Bonnetain, F., et al. (2005). Treatment of advanced hepatocellular carcinoma with long-acting octreotide: Preliminary results of a randomized placebo-controlled trial (FFCD-ANGH 2001–01 CHOC). Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings, 23(16S), 4036. Barbare, J. C., Bouché, O., Bonnetain, F., et al. (2005). Treatment of advanced hepatocellular carcinoma with long-acting octreotide: Preliminary results of a randomized placebo-controlled trial (FFCD-ANGH 2001–01 CHOC). Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings, 23(16S), 4036.
52.
go back to reference Gill, T. M., & Feinstein, A. R. (1994). A critical appraisal of the quality of quality-of-life measurements. The Journal of the American Medical Association, 272, 619–626. PubMedCrossRef Gill, T. M., & Feinstein, A. R. (1994). A critical appraisal of the quality of quality-of-life measurements. The Journal of the American Medical Association, 272, 619–626. PubMedCrossRef
53.
go back to reference Lipscomb, J., Reeve, B. B., Clauser, S. B., et al. (2007). Patient-reported outcomes assessment in cancer trials: Taking stock, moving forward. Journal of Clinical Oncology, 25, 5133–5140. PubMedCrossRef Lipscomb, J., Reeve, B. B., Clauser, S. B., et al. (2007). Patient-reported outcomes assessment in cancer trials: Taking stock, moving forward. Journal of Clinical Oncology, 25, 5133–5140. PubMedCrossRef
54.
go back to reference Simes, R. J., Greatorex, V., & Gebski, V. J. (1998). Practical approaches to minimize problems with missing quality of life data. Statistics in Medicine, 17, 725–737. PubMedCrossRef Simes, R. J., Greatorex, V., & Gebski, V. J. (1998). Practical approaches to minimize problems with missing quality of life data. Statistics in Medicine, 17, 725–737. PubMedCrossRef
55.
go back to reference Bernhard, J., Cella, D. F., Coates, A. S., et al. (1998). Missing quality of life data in cancer clinical trials : Serious problems and challenges. Statistics in Medicine, 17, 517–532. PubMedCrossRef Bernhard, J., Cella, D. F., Coates, A. S., et al. (1998). Missing quality of life data in cancer clinical trials : Serious problems and challenges. Statistics in Medicine, 17, 517–532. PubMedCrossRef
56.
go back to reference Bernhard, J., Sullivan, M., Hurny, C., et al. (2001). Clinical relevance of single item quality of life indicators in cancer clinical trials. British Journal of Cancer, 84, 1156–1165. PubMedCrossRef Bernhard, J., Sullivan, M., Hurny, C., et al. (2001). Clinical relevance of single item quality of life indicators in cancer clinical trials. British Journal of Cancer, 84, 1156–1165. PubMedCrossRef
57.
go back to reference Sloan, J. A., Aaronson, N., Cappelleri, J. C., et al., Clinical Significance Consensus Meeting Group. (2002). Assessing the clinical significance of single items relative to summated scores. Mayo Clinic Proceedings, 77, 479–487. Sloan, J. A., Aaronson, N., Cappelleri, J. C., et al., Clinical Significance Consensus Meeting Group. (2002). Assessing the clinical significance of single items relative to summated scores. Mayo Clinic Proceedings, 77, 479–487.
58.
go back to reference Caumes, J. L., Nousbaum, J. B., Bessaguet, C., et al. (2007). Epidemiology of hepatocellular carcinoma in Finistère. Prospective study from June 2002 to May 2003. Gastroenterologie Clinique et Biologique, 1, 259–264. CrossRef Caumes, J. L., Nousbaum, J. B., Bessaguet, C., et al. (2007). Epidemiology of hepatocellular carcinoma in Finistère. Prospective study from June 2002 to May 2003. Gastroenterologie Clinique et Biologique, 1, 259–264. CrossRef
Metagegevens
Titel
Quality of life as a prognostic factor of overall survival in patients with advanced hepatocellular carcinoma: results from two French clinical trials
Auteurs
Franck Bonnetain
Xavier Paoletti
Sandra Collette
Michel Doffoel
Olivia Bouché
Jean Luc Raoul
Philippe Rougier
Fadil Masskouri
Jean Claude Barbare
Laurent Bedenne
Publicatiedatum
01-08-2008
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 6/2008
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-008-9365-y