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01-08-2008

Quality of life as a prognostic factor of overall survival in patients with advanced hepatocellular carcinoma: results from two French clinical trials

Auteurs: Franck Bonnetain, Xavier Paoletti, Sandra Collette, Michel Doffoel, Olivia Bouché, Jean Luc Raoul, Philippe Rougier, Fadil Masskouri, Jean Claude Barbare, Laurent Bedenne

Gepubliceerd in: Quality of Life Research | Uitgave 6/2008

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Abstract

Aim

The aims of our study were to assess quality of life (QoL) as a prognostic factor of overall survival (OS) and to determine whether QoL data improved three prognostic classifications among French patients with advanced hepatocellular carcinoma (HCC).

Results

Among 538 included patients, QoL at baseline was available for 489 patients (90%). Longer median OS was significantly associated with higher Spitzer scores at baseline, ranging from 2.17 months (Spitzer = 3) to 8.93 months (Spitzer = 10). Variables retained in the multivariate Cox model were: jaundice, hepatomegaly, hepatalgia, portal thrombosis, alphafetoprotein, bilirubin, albumin, small HCC, and Spitzer QoL Index (hazard ratio = 0.84 95% CI [0.79–0.90]). According to Harrell’s C-index, QoL was the best prognostic variable to add. CLIP plus the Spitzer QoL Index had the most discriminating value (C = 0.71).

Conclusions

Our results suggest that QoL is an independent prognostic factor for survival in HCC patients with mainly alcoholic cirrhosis. The prognostic value of CLIP score could be improved by adding Spitzer QOL Index scores.
Literatuur
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Metagegevens
Titel
Quality of life as a prognostic factor of overall survival in patients with advanced hepatocellular carcinoma: results from two French clinical trials
Auteurs
Franck Bonnetain
Xavier Paoletti
Sandra Collette
Michel Doffoel
Olivia Bouché
Jean Luc Raoul
Philippe Rougier
Fadil Masskouri
Jean Claude Barbare
Laurent Bedenne
Publicatiedatum
01-08-2008
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 6/2008
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-008-9365-y