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01-05-2011

Quality of life and related variables in patients with ankylosing spondylitis

Auteurs: Hatice Bodur, Şebnem Ataman, Aylin Rezvani, Derya Soy Buğdaycı, Remzi Çevik, Murat Birtane, Ayşen Akıncı, Zuhal Altay, Rezzan Günaydın, Mahmut Yener, Hikmet Koçyiğit, Tuncay Duruöz, Pelin Yazgan, Engin Çakar, Gülümser Aydın, Simin Hepgüler, Lale Altan, Mehmet Kırnap, Neşe Ölmez, Raikan Soydemir, Erkan Kozanoğlu, Ajda Bal, Konçuy Sivrioğlu, Murat Karkucak, Zafer Günendi

Gepubliceerd in: Quality of Life Research | Uitgave 4/2011

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Abstract

Objectives

To evaluate quality of life (QoL) and related variables in patients with ankylosing spondylitis (AS), a chronic inflammatory disease of the spine.

Methods

Nine-hundred and sixty-two patients with AS from the Turkish League Against Rheumatism AS Registry, who fulfilled the modified New York criteria, were enrolled. The patients were evaluated using the Assessment of SpondyloArthritis International Society core outcome domains including Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), fatigue (BASDAI-question 1), pain (last week/spine/due to AS), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Radiology Index (BASRI), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) and two QoL questionnaires (the disease-specific ASQoL and generic the Short Form-36 [SF-36]).

Results

The mean ASQoL score was 7.1 ± 5.7. SF-36 subscales of general health, physical role and bodily pain had the poorest scores. ASQoL was strongly correlated with disease duration, BASDAI, fatigue, BASFI, BASMI, BASRI, MASES, pain and SF-36 subscales (P < 0.001). SF-36 subscales were also strongly correlated with BASDAI and BASFI. Advanced educational status and regular exercise habits positively affected QoL, while smoking negatively affected QoL.

Conclusions

In patients with AS, the most significant variables associated with QoL were BASDAI, BASFI, fatigue and pain. ASQoL was noted to be a short, rapid and simple patient-reported outcome (PRO) instrument and strongly correlated with SF-36 subscales.
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Metagegevens
Titel
Quality of life and related variables in patients with ankylosing spondylitis
Auteurs
Hatice Bodur
Şebnem Ataman
Aylin Rezvani
Derya Soy Buğdaycı
Remzi Çevik
Murat Birtane
Ayşen Akıncı
Zuhal Altay
Rezzan Günaydın
Mahmut Yener
Hikmet Koçyiğit
Tuncay Duruöz
Pelin Yazgan
Engin Çakar
Gülümser Aydın
Simin Hepgüler
Lale Altan
Mehmet Kırnap
Neşe Ölmez
Raikan Soydemir
Erkan Kozanoğlu
Ajda Bal
Konçuy Sivrioğlu
Murat Karkucak
Zafer Günendi
Publicatiedatum
01-05-2011
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 4/2011
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-010-9771-9