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Gepubliceerd in: Quality of Life Research 10/2011

01-12-2011

Quality of life among testicular cancer survivors: a case–control study in the United States

Auteurs: Christopher Kim, Katherine A. McGlynn, Ruth McCorkle, Ralph L. Erickson, David W. Niebuhr, Shuangge Ma, Barry Graubard, Briseis Aschebrook-Kilfoy, Kathryn Hughes Barry, Yawei Zhang

Gepubliceerd in: Quality of Life Research | Uitgave 10/2011

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Abstract

Introduction

Evidence from previous studies has suggested there may be physical and mental changes in health among testicular cancer survivors. No studies have been conducted in the United States, however.

Methods

Study participants were initially enrolled in the US Servicemen’s Testicular Tumor Environmental and Endocrine Determinants (STEED) study between 2002 and 2005. A total of 246 TGCT (testicular germ cell tumor) cases and 236 non-testicular cancer controls participated in the current study, and completed a self-administered questionnaire. Mean time since diagnosis for cases was 14 years, and no less than five for all cases. Component scores determined from responses to questions about physical and mental health on SF36 were tabulated to yield two summary measures, physical component scores (PCS), and mental component scores (MCS). Component and summary scores were normalized to a score of 50 with a standard deviation of 10 by a linear T-score transformation.

Results

Overall, cases may not suffer greatly in different quality of life than controls. When all cases and controls are compared, TGCT cases had lower PCS (mean: 51.9 95% CI: 50.6–53.2, P value: 0.037) than controls (mean: 53.6 95% CI: 52.7–54.6). MCS were not significantly different (P value: 0.091). In multivariate analyses, several physical health components were worse for TGCT cases such as role-physical (OR 1.19, 95% CI: 1.01–1.39) and general health (OR 1.26, 95% CI: 1.07–1.49) compared to controls. However, TGCT cases treated with chemotherapy had lower PCS (cases: 50.2, 95% CI: 47.6–52.8; controls: 53.6, 95% CI: 52.7–54.6, P value: 0.0032) and MCS (cases: 49.3, 95% CI: 46.5–52.1; controls: 52.0, 95% CI: 50.9–53.2, P value: 0.039). TGCT cases who received treatments other than chemotherapy did not differ from controls in either PCS or MCS.

Discussion

Physical and general health limitations may affect testicular cancer survivors. Men treated with chemotherapy, however, may be most likely to suffer adverse health outcomes due to a combination of body-wide effects on physical and mental factors which affect various aspects of physical health, mental health, and overall quality of life. And in particular, physical functioning, role–physical, and general health are strongly affected.
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Metagegevens
Titel
Quality of life among testicular cancer survivors: a case–control study in the United States
Auteurs
Christopher Kim
Katherine A. McGlynn
Ruth McCorkle
Ralph L. Erickson
David W. Niebuhr
Shuangge Ma
Barry Graubard
Briseis Aschebrook-Kilfoy
Kathryn Hughes Barry
Yawei Zhang
Publicatiedatum
01-12-2011
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 10/2011
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-011-9907-6

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