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Gepubliceerd in: Quality of Life Research 3/2009

01-04-2009

Qualify of life and palliation predict survival in patients with chronic alveolar hypoventilation and nocturnal ventilatory support

Auteurs: Jan Olofson, Catharina Dellborg, Marianne Sullivan, Bengt Midgren, Oscar Caro, Bengt Bergman

Gepubliceerd in: Quality of Life Research | Uitgave 3/2009

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Abstract

Objectives

Non-invasive positive pressure ventilation (NPPV) improves health-related quality of life (HRQL) in patients with chronic alveolar hypoventilation (CAH). We studied the prognostic impact of HRQL on survival in relation to clinical factors.

Patients

Forty-four patients with CAH due to post-polio (12), scoliosis (11), post-tb (17) or other diagnoses (4) who received nocturnal NPPV were prospectively studied during 6–10 years.

Measurements

Blood gases and HRQL were analysed at baseline and after 9 months and after 8 years. HRQL was evaluated with measures of functioning (SIP), emotional well-being (HADS and MACL), and global QL.

Results

Blood gases and HRQL measures improved during NPPV. The overall 5-year survival rate was 73%. In multivariate survival analysis, a diagnosis of post-polio and low baseline SIP physical index scores, indicating low levels of physical dysfunction, predicted longer survival (P = 0.02, respectively). Similarly, palliation of physical dysfunction and preserved or improved global QL by 9 months were associated with longer overall survival (P = 0.009 and P = 0.001, respectively; multivariate Cox regression).

Conclusion

Seventy-three percent of patients treated for CAH with NPPV survived more than 5 years. Diagnosis and self-rated physical functioning at pre-treatment were related to survival, as were major improvements in physical functioning and global QL during NPPV.
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Metagegevens
Titel
Qualify of life and palliation predict survival in patients with chronic alveolar hypoventilation and nocturnal ventilatory support
Auteurs
Jan Olofson
Catharina Dellborg
Marianne Sullivan
Bengt Midgren
Oscar Caro
Bengt Bergman
Publicatiedatum
01-04-2009
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 3/2009
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-009-9445-7

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