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Quality of Life Research

Gepubliceerd in:

23-03-2020

Psychotropic polypharmacy and its association with health-related quality of life among cancer survivors in the USA: a population-level analysis

Auteurs: Ami Vyas, Ghadah Alghaith, Meghan Hufstader-Gabriel

Gepubliceerd in: Quality of Life Research | Uitgave 8/2020

Abstract

Purpose

Cancer survivors that use multiple psychotropic medications are at an increased risk of psychotropic polypharmacy. We examined the association between psychotropic polypharmacy and health-related quality of life (HRQoL) among cancer survivors living in the USA.

Methods

We used the Medical Expenditure Panel Survey (MEPS) data for 2010, 2012, and 2014 to identify adult cancer survivors. Psychotropic polypharmacy was defined as use of at least two classes of psychotropic prescription medications. The physical component summary (PCS) and the mental component summary (MCS) were obtained from the 12-item Short Form Health Survey version 2 to measure HRQoL. Adjusted ordinary least square regressions were performed to evaluate the association between psychotropic polypharmacy and HRQoL.

Results

Among 31 million US cancer survivors (weighted from a sample of 2609), 16.3% reported psychotropic polypharmacy. Lung cancer survivors had the highest prevalence of psychotropic polypharmacy (22.5%), followed by survivors of breast cancer (17.8%), colorectal, and other gastrointestinal cancers (16.0%). The unadjusted PCS and MCS scores for those with psychotropic polypharmacy were significantly lower than those without psychotropic polypharmacy, overall, and for each cancer type. In multivariable regressions, cancer survivors with psychotropic polypharmacy had significantly lower PCS scores (β = − 3.63, p < 0.0001) and MCS scores (β = − 2.28, p = 0.0138) compared to those without psychotropic polypharmacy.

Conclusion

Cancer survivors requiring multiple psychotropic medications have poorer quality of life.

vorige artikel Patient-reported outcomes in melanoma survivors at 1, 3 and 5 years post-diagnosis: a population-based cross-sectional study

volgende artikel Body composition and changes in health-related quality of life in older age: a 10-year follow-up of the Helsinki Birth Cohort Study

Alleen toegankelijk voor geautoriseerde gebruikers

Bluethmann, S. M., Mariotto, A. B., & Rowland, J. H. (2016). Anticipating the “Silver Tsunami”: Prevalence trajectories and comorbidity burden among older cancer survivors in the United States. Cancer Epidemiology, Biomarkers & Prevention,25, 1029–1036.CrossRef

Singer, S., Das-Munshi, J., & Brahler, E. (2010). Prevalence of mental health conditions in cancer patients in acute care-a meta-analysis. Annals of Oncology,21, 925–930.CrossRef

Mitchell, A. J., Chan, M., Bhatti, H., et al. (2011). Prevalence of depression, anxiety, and adjustment disorders in oncological, haematological, and palliative care settings: A meta-analysis of 94 interview-based studies. Lancet,12(2), 160–174.CrossRef

Ng, C. G., Boks, M. P., Smeets, H. M., Zainal, N. Z., & de Wit, N. J. (2013). Prescription patterns for psychotropic drugs in cancer patients: A large population study in the Netherlands. Psychooncology,22(4), 762–767.CrossRef

Farriols, C., Ferrandez, O., Planas, J., Ortiz, P., Mojal, S., & Ruiz, A. I. (2012). Changes in the prescription of psychotropic drugs in the palliative care of advanced cancer patients over a seven-year period. Journal of Pain and Symptom Management,43(5), 945–952.CrossRef

Punekar, R. S., Short, P. F., & Moran, J. R. (2012). Use of psychotropic medications by US cancer survivors. Psychooncology,21(11), 1237–1243.CrossRef

Bruera, E., & Neumann, C. (1998). The uses of psychotropics in symptom management in advanced cancer. Psychooncology,7(4), 346–358.CrossRef

Thekdi, S. M., Irarrazaval, M. E., & Dunn, L. B. (2012). Psychopharmacological interventions. In L. Grass & M. Riba (Eds.), Clinical psycho-oncology: An international perspective (pp. 109–126). Chichester: Willey-Blackwell.CrossRef

Mojtabai, R., & Olfson, M. (2010). National trends in psychotropic medication polypharmacy in office-based psychiatry. Archives of General Psychiatry,67(1), 26–36.CrossRef

10.

Correll, C. U., & Gallego, J. A. (2012). Antipsychotic polypharmacy: A comprehensive evaluation of relevant correlates of a long-standing clinical practice. Psychiatric Clinics of North America,35(3), 661–681.CrossRef

11.

Sandson, N. B., Armstrong, S. C., & Cozza, K. L. (2005). An overview of psychotropic drug-drug interactions. Psychosomatics,46(5), 464–494.CrossRef

12.

Yap, K. Y., Tay, W. L., Chui, W. K., & Chan, A. (2011). Clinically relevant drug interactions between anticancer drugs and psychotropic agents. European Journal of Cancer Care (England),20(1), 6–32.CrossRef

13.

Aroke, H., Vyas, A., Buchanan, A., & Kogut, S. (2019). Prevalence of psychotropic polypharmacy and associated healthcare utilization during initial phase of care among adults with cancer in USA. Drugs Real World Outcomes,6(2), 73–82.CrossRef

14.

Vyas, A., Kogut, S., & Aroke, H. (2019). Real-world direct healthcare costs associated with psychotropic polypharmacy among adults with common cancer types in the United States. Journal of Managed Care & Specialty Pharmacy,25(5), 555–565.CrossRef

15.

Harrison, S. L., Bradley, C., Milte, R., et al. (2018). Psychotropic medications in older people in residential care facilities and associations with quality of life: A cross-sectional study. BMC Geriatrics,18, 60.CrossRef

16.

Thompson Coon, J., Abbott, R., Rogers, M., et al. (2014). Interventions to reduce inappropriate prescribing of antipsychotic medications in people with dementia resident in care homes: A systematic review. Journal of the American Medical Directors Association,15(10), 706–718.CrossRef

17.

Agency for Healthcare Research and Quality. (2014). Medical expenditure panel survey, HC-171: 2014 Full Year Consolidated Data File. Retrieved July 17, 2019 from https://meps.ahrq.gov/data_stats/download_data/pufs/h171/h171doc.pdf.

18.

Medical Expenditure Panel Survey Clinical Classification Code to ICD-9-CM Code Crosswalk. Retrieved July 17, 2019 from https://meps.ahrq.gov/mepsweb/data_stats/download_data/pufs/h128/h128_icd9codes.shtml.

19.

Ware, J., Jr., Kosinski, M., & Keller, S. D. (1996). A 12-item short-form health survey: Construction of scales and preliminary tests of reliability and validity. Medical Care,34, 220–233.CrossRef

20.

Ware, J., Jr., Kosinski, M., Turner-Bowker, D. M., & Gandek, B. (2002). SF-12v2: How to score version 2 of the SF-12 health survey (with a supplement documenting version 1). Lincoln, RI: QualityMetric Inc.

21.

Braun, I. M., Rao, S. R., Meyer, F. L., & Fedele, G. (2015). Patterns of psychiatric medication use among nationally representative long-term cancer survivors and controls. Cancer,121, 132–138.CrossRef

22.

Jones, S. M., Rosenberg, D., Ludman, E., & Arterburn, D. (2015). Medical comorbidity and psychotropic medication fills in older adults with breast or prostate cancer. Supportive Care in Cancer,23(10), 3005–3009.CrossRef

23.

Bradley, S., Rose, S., Lutgendorf, S., Costanzo, E., & Anderson, B. (2006). Quality of life and mental health in cervical and endometrial cancer survivors. Gynecologic Oncology,100(3), 479–486.CrossRef

24.

Fleer, J., Hoekstra, H. J., Sleijfer, D. T., Tuinman, M. A., Klip, E. C., & Hoekstra-Weebers, J. E. (2006). Quality of life of testicular cancer survivors and the relationship with socio-demographics, cancer-related variables, and life events. Supportive Care in Cancer,14(3), 251–259.CrossRef

25.

Peuckmann, V., Ekholm, O., Rasmussen, N. K., et al. (2007). Health-related quality of life in long-term breast cancer survivors: Nationwide survey in Denmark. Breast Cancer Research and Treatment,104(1), 39–46.CrossRef

26.

Wang, S., Hsu, S. H., Gross, C. P., et al. (2016). Association between time since cancer diagnosis and health-related quality of life: A population-level analysis. Value Health,19, 631–638.CrossRef

27.

Hays, R. D., & Morales, L. S. (2001). The RAND-36 measure of health-related quality of life. Annals of Medicine,33, 350–357.CrossRef

28.

Paltiel, O., Marzec-Boguslawska, A., Soskolne, V., et al. (2004). Use of tranquilizers and sleeping pills among cancer patients is associated with a poorer quality of life. Quality of Life Research,13(10), 1699–1706.CrossRef

29.

Stein, M. B., & Barrett-Connor, E. (2002). Quality of life in older adults receiving medications for anxiety, depression or insomnia: Findings from a community-based study. American Journal of Geriatric Psychiatry,10(5), 568–574.CrossRef

30.

Liavaag, A. H., Dorum, A., Fossa, S. D., Trope, C., & Dahl, A. A. (2009). Morbidity associated with ‘self-rated health’ in epithelial ovarian cancer survivors. BMC Cancer,9, 2.CrossRef

31.

Krebber, A. M., Jansen, F., Witte, B. I., et al. (2016). Stepped care targeting psychological distress in head and neck cancer and lung cancer patients: A randomized, controlled trial. Annals of Oncology,27(9), 1754–1760.CrossRef

32.

Yabroff, K. R., Warren, J. L., Banthin, J., et al. (2009). Comparison of approaches for estimating prevalence costs of care for cancer patients: What is the impact of data source? Medical Care,47(7 Suppl 1), S64.CrossRef

33.

Ereshefsky, L., & Sloan, D. M. (2009). Drug–drug interactions with the use of psychotropic medications. CNS Spectrums,14(8), 1–8.PubMed

Titel: Psychotropic polypharmacy and its association with health-related quality of life among cancer survivors in the USA: a population-level analysis
Auteurs: Ami Vyas
Ghadah Alghaith
Meghan Hufstader-Gabriel
Publicatiedatum: 23-03-2020
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 8/2020
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-020-02478-6

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