Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

05-11-2016 | Original Paper

Psychotropic Medication Use among Insured Children with Autism Spectrum Disorder

Auteurs: Jeanne M. Madden, Matthew D. Lakoma, Frances L. Lynch, Donna Rusinak, Ashli A. Owen-Smith, Karen J. Coleman, Virginia P. Quinn, Vincent M. Yau, Yinge X. Qian, Lisa A. Croen

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2017

Abstract

This study examined psychotropic medication use among 7901 children aged 1–17 with autism spectrum disorder (ASD) in five health systems, comparing to matched cohorts with no ASD. Nearly half (48.5 %) of children with ASD received psychotropics in the year observed; the most common classes were stimulants, alpha-agonists, or atomoxetine (30.2 %), antipsychotics (20.5 %), and antidepressants (17.8 %). Psychotropic treatment was far more prevalent among children with ASD, as compared to children with no ASD (7.7 % overall), even within strata defined by the presence or absence of other psychiatric diagnoses. The widespread use of psychotropics we observed, particularly given weak evidence supporting the effectiveness of these medications for most children with ASD, highlights challenges in ASD treatment and the need for greater investment in its evaluation.

vorige artikel Characteristics of Autism Spectrum Disorder in Sotos Syndrome

volgende artikel Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD)

Alleen toegankelijk voor geautoriseerde gebruikers

Ahmedani, B. K., Simon, G. E., Stewart, C., Beck, A., Waitzfelder, B. E., Rossom, R., et al. (2014). Health care contacts in the year before suicide death. Journal of General Internal Medicine: Official Journal of the Society for Research and Education in Primary Care Internal Medicine, 29(6), 870–877. doi:10.1007/s11606-014-2767-3.CrossRef

Aman, M. G., Lam, K. S., & Collier-Crespin, A. (2003). Prevalence and patterns of use of psychoactive medicines among individuals with autism in the Autism Society of Ohio. Journal of Autism and Developmental Disorders, 33(5), 527–534.CrossRefPubMed

American Academy of Child and Adolescent Psychiatry. (2011). Practice parameter for the use of atypical antipsychotic medications in children and adolescents. Retrieved from 3615 Wisconsin Ave., NW, Washington, D.C. 20016: https://www.aacap.org/App_Themes/AACAP/docs/practice_parameters/Atypical_Antipsychotic_Medications_Web.pdf.

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, (DSM-5®): American Psychiatric Association.

American Psychiatric Association, & American Psychiatric Association. Task Force on DSM-IV. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR (4th ed.). Washington, DC: American Psychiatric Association.

Biederman, J., Mick, E., Faraone, S. V., Braaten, E., Doyle, A., Spencer, T., et al. (2002). Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic. The American Journal of Psychiatry, 159(1), 36–42. doi:10.1176/appi.ajp.159.1.36.CrossRefPubMed

Bishop, T. F., Press, M. J., Keyhani, S., & Pincus, H. A. (2014). Acceptance of insurance by psychiatrists and the implications for access to mental health care. JAMA Psychiatry, 71(2), 176–181. doi:10.1001/jamapsychiatry.2013.2862.CrossRefPubMedPubMedCentral

Burke, J. P., Jain, A., Yang, W., Kelly, J. P., Kaiser, M., Becker, L., et al. (2014). Does a claims diagnosis of autism mean a true case? Autism: The International Journal of Research and Practice, 18(3), 321–330. doi:10.1177/1362361312467709.CrossRef

Canitano, R. (2007). Epilepsy in autism spectrum disorders. European Child and Adolescent Psychiatry, 16(1), 61–66. doi:10.1007/s00787-006-0563-2.CrossRefPubMed

Canitano, R. (2015). Mood stabilizers in children and adolescents with autism spectrum Disorders. Clinical Neuropharmacology, 38(5), 177–182. doi:10.1097/WNF.0000000000000096.CrossRefPubMed

Cohen, P., Cohen, J., Kasen, S., Velez, C. N., Hartmark, C., Johnson, J., et al. (1993). An epidemiological study of disorders in late childhood and adolescence–I. Age- and gender-specific prevalence. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 34(6), 851–867.CrossRefPubMed

Coleman, K. J., Lutsky, M. A., Yau, V., Qian, Y., Pomichowski, M. E., Crawford, P. M., et al. (2015). Validation of autism spectrum disorder diagnoses in large healthcare systems with electronic medical records. Journal of Autism and Developmental Disorders. doi:10.1007/s10803-015-2358-0.PubMedPubMedCentral

Costello, E. J., Egger, H., & Angold, A. (2005). 10-year research update review: The epidemiology of child and adolescent psychiatric disorders: I. Methods and public health burden. Journal of the American Academy of Child and Adolescent Psychiatry, 44(10), 972–986. doi:10.1097/01.chi.0000172552.41596.6f.CrossRefPubMed

Croen, L. A., Najjar, D. V., Ray, G. T., Lotspeich, L., & Bernal, P. (2006). A comparison of health care utilization and costs of children with and without autism spectrum disorders in a large group-model health plan. Pediatrics, 118(4), e1203–e1211. doi:10.1542/peds.2006-0127.CrossRefPubMed

Cummings, J. R., Lynch, F. L., Rust, K. C., Coleman, K. J., Madden, J. M., Owen-Smith, A. A., et al. (2016). Health services utilization among children with and without autism spectrum disorders. Journal of Autism and Developmental Disorders, 46(3), 910–920. doi:10.1007/s10803-015-2634-z.CrossRefPubMed

Dawson, G. (2013). Dramatic increase in autism prevalence parallels explosion of research into its biology and causes. JAMA Psychiatry, 70(1), 9–10. doi:10.1001/jamapsychiatry.2013.488.CrossRefPubMed

Developmental, D. M. N. S. Y., & 2010 Principal Investigators. (2014). Prevalence of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summary, 63(2), 1–21.

Dove, D., Warren, Z., McPheeters, M. L., Taylor, J. L., Sathe, N. A., & Veenstra-VanderWeele, J. (2012). Medications for adolescents and young adults with autism spectrum disorders: A systematic review. Pediatrics, 130(4), 717–726. doi:10.1542/peds.2012-0683.CrossRefPubMedPubMedCentral

Esbensen, A. J., Greenberg, J. S., Seltzer, M. M., & Aman, M. G. (2009). A longitudinal investigation of psychotropic and non-psychotropic medication use among adolescents and adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(9), 1339–1349. doi:10.1007/s10803-009-0750-3.CrossRefPubMedPubMedCentral

Glasser, M. (2010). The history of managed care and the role of the child and adolescent psychiatrist. Child Adolescent Psychiatric Clinics of North America, 19(1), 63–74. doi:10.1016/j.chc.2009.08.009.CrossRefPubMed

Harstad, E., Levy, S., & Committee on Substance, A. (2014). Attention-deficit/hyperactivity disorder and substance abuse. Pediatrics, 134(1), e293–301. doi:10.1542/peds.2014-0992.CrossRefPubMed

Hartley, S. L., & Sikora, D. M. (2009). Sex differences in autism spectrum disorder: An examination of developmental functioning, autistic symptoms, and coexisting behavior problems in toddlers. Journal of Autism and Developmental Disorders, 39(12), 1715–1722. doi:10.1007/s10803-009-0810-8.CrossRefPubMedPubMedCentral

Johnson, C. P., & Myers, S. M. (2007). Identification and evaluation of children with autism spectrum disorders. Pediatrics, 120(5), 1183–1215. doi:10.1542/peds.2007-2361.CrossRefPubMed

Karst, J. S., & Van Hecke, A. V. (2012). Parent and family impact of autism spectrum disorders: A review and proposed model for intervention evaluation. Clinical Child and Family Psychology Review, 15(3), 247–277. doi:10.1007/s10567-012-0119-6.CrossRefPubMed

Kessler, R. C., Avenevoli, S., & Ries Merikangas, K. (2001). Mood disorders in children and adolescents: An epidemiologic perspective. Biological Psychiatry, 49(12), 1002–1014.CrossRefPubMed

Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, S., Holdgrafer, M., & McLennan, J. (1989). Autism diagnostic interview: a standardized investigator-based instrument. Journal of Autism and Developmental Disorders, 19(3), 363–387.CrossRefPubMed

Logan, S. L., Nicholas, J. S., Carpenter, L. A., King, L. B., Garrett-Mayer, E., & Charles, J. M. (2012). High prescription drug use and associated costs among Medicaid-eligible children with autism spectrum disorders identified by a population-based surveillance network. Annals of Epidemiology, 22(1), 1–8. doi:10.1016/j.annepidem.2011.10.007.CrossRefPubMedPubMedCentral

Lord, C., Petkova, E., Hus, V., Gan, W., Lu, F., Martin, D. M., et al. (2012). A multisite study of the clinical diagnosis of different autism spectrum disorders. Archives of General Psychiatry, 69(3), 306–313. doi:10.1001/archgenpsychiatry.2011.148.CrossRefPubMed

Lord, C., Risi, S., Lambrecht, L., Cook, E. H. Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.CrossRefPubMed

Lu, C. Y., Zhang, F., Lakoma, M. D., Madden, J. M., Rusinak, D., Penfold, R. B., … Soumerai, S. B. (2014). Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: Quasi-experimental study. BMJ, 348, g3596.CrossRefPubMedPubMedCentral

Mandell, D. S., Morales, K. H., Marcus, S. C., Stahmer, A. C., Doshi, J., & Polsky, D. E. (2008). Psychotropic medication use among Medicaid-enrolled children with autism spectrum disorders. Pediatrics, 121(3), e441–e448. doi:10.1542/peds.2007-0984.CrossRefPubMedPubMedCentral

Matson, J. L., & Kozlowski, A. M. (2011). The increasing prevalence of autism spectrum disorders. Research in Autism Spectrum Disorders, 5.1, 418–425.CrossRef

Mazefsky, C. A., Herrington, J., Siegel, M., Scarpa, A., Maddox, B. B., Scahill, L., & White, S. W. (2013). The role of emotion regulation in autism spectrum disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 52(7), 679–688. doi:10.1016/j.jaac.2013.05.006.CrossRefPubMedPubMedCentral

Mazzone, L., Ruta, L., & Reale, L. (2012). Psychiatric comorbidities in asperger syndrome and high functioning autism: Diagnostic challenges. Annals of General Psychiatry, 11(1), 16. doi:10.1186/1744-859x-11-16.CrossRefPubMedPubMedCentral

McPheeters, M. L., Warren, Z., Sathe, N., Bruzek, J. L., Krishnaswami, S., Jerome, R. N., & Veenstra-Vanderweele, J. (2011). A systematic review of medical treatments for children with autism spectrum disorders. Pediatrics, 127(5), e1312–e1321. doi:10.1542/peds.2011-0427.CrossRefPubMed

MHRN. Mental Health Research Network (website). Retrieved from http://www.mhresearchnetwork.org/.

Oswald, D. P., & Sonenklar, N. A. (2007). Medication use among children with autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 17(3), 348–355. doi:10.1089/cap.2006.17303.CrossRefPubMed

Penfold, R. B., Stewart, C., Hunkeler, E. M., Madden, J. M., Cummings, J. R., Owen-Smith, A. A., et al. (2013). Use of antipsychotic medications in pediatric populations: What do the data say? Current Psychiatry Reports, 15(12), 426. doi:10.1007/s11920-013-0426-8.CrossRefPubMedPubMedCentral

Peters-Scheffer, N., Didden, R., Korzilius, H., & Sturmey, P. (2011). A meta-analytic study on the effectiveness of comprehensive ABA-based early intervention programs for children with autism spectrum disorders. Research in Autism Spectrum Disorders, 5.1, 60–69.CrossRef

Pletcher, B. A., Rimsza, M. E., Cull, W. L., Shipman, S. A., Shugerman, R. P., & O’Connor, K. G. (2010). Primary care pediatricians’ satisfaction with subspecialty care, perceived supply, and barriers to care. Journal of Pediatrics, 156(6), 1011–1015, 1015.e1. doi:10.1016/j.jpeds.2009.12.032.CrossRefPubMed

Rosenberg, R. E., Mandell, D. S., Farmer, J. E., Law, J. K., Marvin, A. R., & Law, P. A. (2010). Psychotropic medication use among children with autism spectrum disorders enrolled in a national registry, 2007–2008. Journal of Autism and Developmental Disorders, 40(3), 342–351. doi:10.1007/s10803-009-0878-1.CrossRefPubMed

Siegel, M., & Beaulieu, A. A. (2012). Psychotropic medications in children with autism spectrum disorders: A systematic review and synthesis for evidence-based practice. Journal of Autism and Developmental Disorders, 42(8), 1592–1605. doi:10.1007/s10803-011-1399-2.CrossRefPubMed

Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 921–929. doi:10.1097/CHI.0b013e318179964f.CrossRefPubMed

Solomon, M., Miller, M., Taylor, S. L., Hinshaw, S. P., & Carter, C. S. (2012). Autism symptoms and internalizing psychopathology in girls and boys with autism spectrum disorders. Journal of Autism and Developmental Disorders, 42(1), 48–59. doi:10.1007/s10803-011-1215-z.CrossRefPubMed

Thomas, C. R., & Holzer, C. E. (2006). The continuing shortage of child and adolescent psychiatrists. Journal of American Academy Child Adolescent Psychiatry, 45(9), 1023–1031. doi:10.1097/01.chi.0000225353.16831.5d.CrossRef

Titel: Psychotropic Medication Use among Insured Children with Autism Spectrum Disorder
Auteurs: Jeanne M. Madden
Matthew D. Lakoma
Frances L. Lynch
Donna Rusinak
Ashli A. Owen-Smith
Karen J. Coleman
Virginia P. Quinn
Vincent M. Yau
Yinge X. Qian
Lisa A. Croen
Publicatiedatum: 05-11-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-016-2946-7

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 1/2017

Brief Report: Which Came First? Exploring Crossmodal Temporal Order Judgements and Their Relationship with Sensory Reactivity in Autism and Neurotypicals

Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD)

Parents Perceive Improvements in Socio-emotional Functioning in Adolescents with ASD Following Social Skills Treatment

Emotion Regulation in Young Children with Autism Spectrum Disorders

Physical Activity, Screen-Time Behavior, and Obesity Among 13-Year Olds in Ireland with and without Autism Spectrum Disorder

Parent-Endorsed Sex Differences in Toddlers with and Without ASD: Utilizing the M-CHAT