Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Child Psychiatry & Human Development 2/2022

27-01-2021 | Article

Psychopharmacological Treatments in Children with Fetal Alcohol Spectrum Disorders: A Review

Auteurs: Gaby J. Ritfeld, Julie A. Kable, Jennifer E. Holton, Claire D. Coles

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 2/2022

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Psychiatric symptoms in children with Fetal Alcohol Spectrum Disorders (FASD) present with high prevalence and morbidity, often across symptom domains, e.g. ADHD-like symptoms, emotional dysregulation and sleep problems. Polypharmacy is often used, but no empirically-based guidelines exist regarding optimal treatment for these children. Moreover, stimulant use in these children is controversial as their responsiveness may be different due to altered neural circuitry associated with prenatal alcohol exposure. The objective of this review is to give an overview of existing data on pharmacological treatments of neurobehavioral symptoms in FASD. Our literature review yielded limited and conflicting clinical data on the effectiveness of pharmacological treatments for psychiatric symptoms in children with FASD, with some symptom domains lacking data altogether. We emphasize the need for clinical trials to guide pharmacological treatments in this complex population.
Literatuur
1.
go back to reference May PA, Chambers CD, Kalberg WO, Zellner J, Feldman H, Buckley D et al (2018) Prevalence of fetal alcohol spectrum disorders in 4 US communities. JAMA 319:474–482 CrossRef May PA, Chambers CD, Kalberg WO, Zellner J, Feldman H, Buckley D et al (2018) Prevalence of fetal alcohol spectrum disorders in 4 US communities. JAMA 319:474–482 CrossRef
2.
go back to reference May PA, Baete A, Russo J, Elliott AJ, Blankenship J, Kalberg WO et al (2014) Prevalence and characteristics of fetal alcohol spectrum disorders. Pediatrics 134:855–866 CrossRef May PA, Baete A, Russo J, Elliott AJ, Blankenship J, Kalberg WO et al (2014) Prevalence and characteristics of fetal alcohol spectrum disorders. Pediatrics 134:855–866 CrossRef
3.
go back to reference O’Connor MJ, Paley B (2009) Psychiatric conditions associated with prenatal alcohol exposure. Dev Disabil Res Rev 15:225–234 CrossRef O’Connor MJ, Paley B (2009) Psychiatric conditions associated with prenatal alcohol exposure. Dev Disabil Res Rev 15:225–234 CrossRef
4.
go back to reference Han JY, Kwon HJ, Ha M, Paik KC, Lim MH, Gyu LS et al (2015) The effects of prenatal exposure to alcohol and environmental tobacco smoke on risk for ADHD: a large population-based study. Psychiatry Res 225:164–168 CrossRef Han JY, Kwon HJ, Ha M, Paik KC, Lim MH, Gyu LS et al (2015) The effects of prenatal exposure to alcohol and environmental tobacco smoke on risk for ADHD: a large population-based study. Psychiatry Res 225:164–168 CrossRef
5.
go back to reference Mattson SN, Bernes GA, Doyle LR (2019) Fetal alcohol spectrum disorders: a review of the neurobehavioral deficits associated with prenatal alcohol exposure. Alcohol Clin Exp Res 43:1046–1062 PubMedPubMedCentral Mattson SN, Bernes GA, Doyle LR (2019) Fetal alcohol spectrum disorders: a review of the neurobehavioral deficits associated with prenatal alcohol exposure. Alcohol Clin Exp Res 43:1046–1062 PubMedPubMedCentral
6.
go back to reference Lees B, Mewton L, Jacobus J, Valadez EA, Stapinski LA, Teesson M et al (2020) Association of prenatal alcohol exposure with psychological, behavioral, and neurodevelopmental outcomes in children from the adolescent brain cognitive development study. Am J Psychiatry 177:1060–1072 CrossRef Lees B, Mewton L, Jacobus J, Valadez EA, Stapinski LA, Teesson M et al (2020) Association of prenatal alcohol exposure with psychological, behavioral, and neurodevelopmental outcomes in children from the adolescent brain cognitive development study. Am J Psychiatry 177:1060–1072 CrossRef
7.
go back to reference Mukherjee RAS, Cook PA, Norgate SH, Price AD (2019) Neurodevelopmental outcomes in individuals with fetal alcohol spectrum disorder (FASD) with and without exposure to neglect: clinical cohort data from a national FASD diagnostic clinic. Alcohol 76:23–28 CrossRef Mukherjee RAS, Cook PA, Norgate SH, Price AD (2019) Neurodevelopmental outcomes in individuals with fetal alcohol spectrum disorder (FASD) with and without exposure to neglect: clinical cohort data from a national FASD diagnostic clinic. Alcohol 76:23–28 CrossRef
8.
go back to reference Fryer SL, McGee CL, Matt GE, Riley EP, Mattson SN (2007) Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure. Pediatrics 119:e733-741 CrossRef Fryer SL, McGee CL, Matt GE, Riley EP, Mattson SN (2007) Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure. Pediatrics 119:e733-741 CrossRef
9.
go back to reference Infante MA, Moore EM, Nguyen TT, Fourligas N, Mattson SN, Riley EP (2015) Objective assessment of ADHD core symptoms in children with heavy prenatal alcohol exposure. Physiol Behav 148:45–50 CrossRef Infante MA, Moore EM, Nguyen TT, Fourligas N, Mattson SN, Riley EP (2015) Objective assessment of ADHD core symptoms in children with heavy prenatal alcohol exposure. Physiol Behav 148:45–50 CrossRef
10.
go back to reference American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders. APA, Arlington, VA CrossRef American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders. APA, Arlington, VA CrossRef
12.
go back to reference Kable JA, O’Connor MJ, Olson HC, Paley B, Mattson SN, Anderson SM et al (2016) Neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE): proposed DSM-5 diagnosis. Child Psychiatry Hum Dev 47:335–346 CrossRef Kable JA, O’Connor MJ, Olson HC, Paley B, Mattson SN, Anderson SM et al (2016) Neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE): proposed DSM-5 diagnosis. Child Psychiatry Hum Dev 47:335–346 CrossRef
13.
go back to reference Jensen PS (1999) A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA cooperative group. Multimodal treatment study of children with ADHD. Arch Gen Psychiatry 56:1073–1086 CrossRef Jensen PS (1999) A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA cooperative group. Multimodal treatment study of children with ADHD. Arch Gen Psychiatry 56:1073–1086 CrossRef
14.
go back to reference Coles CD, Platzman KA, Raskind-Hood CL, Brown RT, Falek A, Smith IE (1997) A comparison of children affected by prenatal alcohol exposure and attention deficit, hyperactivity disorder. Alcohol Clin Exp Res 21:150–161 CrossRef Coles CD, Platzman KA, Raskind-Hood CL, Brown RT, Falek A, Smith IE (1997) A comparison of children affected by prenatal alcohol exposure and attention deficit, hyperactivity disorder. Alcohol Clin Exp Res 21:150–161 CrossRef
15.
go back to reference O’Connor MJ (2001) Prenatal alcohol exposure and infant negative affect as precursors of depressive features in children. Infant Ment Health J 22:291–299 CrossRef O’Connor MJ (2001) Prenatal alcohol exposure and infant negative affect as precursors of depressive features in children. Infant Ment Health J 22:291–299 CrossRef
16.
go back to reference Schneider ML, Moore CF, Barnhart TE, Larson JA, DeJesus OT, Mukherjee J et al (2005) Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys. Alcohol Clin Exp Res 29:1685–1697 CrossRef Schneider ML, Moore CF, Barnhart TE, Larson JA, DeJesus OT, Mukherjee J et al (2005) Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys. Alcohol Clin Exp Res 29:1685–1697 CrossRef
17.
go back to reference Riikonen RS, Nokelainen P, Valkonen K, Kolehmainen AI, Kumpulainen KI, Kononen M et al (2005) Deep serotonergic and dopaminergic structures in fetal alcoholic syndrome: a study with nor-beta-CIT-single-photon emission computed tomography and magnetic resonance imaging volumetry. Biol Psychiatry 57:1565–1572 CrossRef Riikonen RS, Nokelainen P, Valkonen K, Kolehmainen AI, Kumpulainen KI, Kononen M et al (2005) Deep serotonergic and dopaminergic structures in fetal alcoholic syndrome: a study with nor-beta-CIT-single-photon emission computed tomography and magnetic resonance imaging volumetry. Biol Psychiatry 57:1565–1572 CrossRef
18.
go back to reference Ulug S, Riley EP (1983) The effect of methylphenidate on overactivity in rats prenatally exposed to alcohol. Neurobehav Toxicol Teratol 5:35–39 PubMed Ulug S, Riley EP (1983) The effect of methylphenidate on overactivity in rats prenatally exposed to alcohol. Neurobehav Toxicol Teratol 5:35–39 PubMed
19.
go back to reference Means L, Hughes V, Grey S (1984) Rats exposed in utero to ethanol are hyperresponsive to methylphenidate when tested as neonates or adults. Neurobehav Toxicol Teratol 6:187–192 PubMed Means L, Hughes V, Grey S (1984) Rats exposed in utero to ethanol are hyperresponsive to methylphenidate when tested as neonates or adults. Neurobehav Toxicol Teratol 6:187–192 PubMed
20.
go back to reference Hannigan JH, Pilati ML (1991) The effects of chronic postweaning amphetamine on rats exposed to alcohol in utero: weight gain and behavior. Neurotoxicol Teratol 13:649–656 CrossRef Hannigan JH, Pilati ML (1991) The effects of chronic postweaning amphetamine on rats exposed to alcohol in utero: weight gain and behavior. Neurotoxicol Teratol 13:649–656 CrossRef
21.
go back to reference Randall S, Hannigan JH (1999) In utero alcohol and postnatal methylphenidate: locomotion and dopamine receptors. Neurotoxicol Teratol 21:587–593 CrossRef Randall S, Hannigan JH (1999) In utero alcohol and postnatal methylphenidate: locomotion and dopamine receptors. Neurotoxicol Teratol 21:587–593 CrossRef
22.
go back to reference Juarez J, Guerrero-Alvarez A (2015) Effects of methylphenidate and atomoxetine on impulsivity and motor activity in preadolescent rats prenatally-treated with alcohol. Behav Neurosci 129:756–764 CrossRef Juarez J, Guerrero-Alvarez A (2015) Effects of methylphenidate and atomoxetine on impulsivity and motor activity in preadolescent rats prenatally-treated with alcohol. Behav Neurosci 129:756–764 CrossRef
23.
go back to reference Shen RY, Choong KC (2006) Different adaptations in ventral tegmental area dopamine neurons in control and ethanol exposed rats after methylphenidate treatment. Biol Psychiatry 59:635–642 CrossRef Shen RY, Choong KC (2006) Different adaptations in ventral tegmental area dopamine neurons in control and ethanol exposed rats after methylphenidate treatment. Biol Psychiatry 59:635–642 CrossRef
24.
go back to reference Aglawe MM, Kale MB, Rahangdale SR, Kotagale NR, Umekar MJ, Taksande BG 2020 Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats. Brain Res Bull 167:37-47 Aglawe MM, Kale MB, Rahangdale SR, Kotagale NR, Umekar MJ, Taksande BG 2020 Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats. Brain Res Bull 167:37-47
25.
go back to reference Frankel F, Paley B, Marquardt R, O’Connor M (2006) Stimulants, neuroleptics, and children’s friendship training for children with fetal alcohol spectrum disorders. J Child Adolesc Psychopharmacol 16:777–789 CrossRef Frankel F, Paley B, Marquardt R, O’Connor M (2006) Stimulants, neuroleptics, and children’s friendship training for children with fetal alcohol spectrum disorders. J Child Adolesc Psychopharmacol 16:777–789 CrossRef
26.
go back to reference Oesterheld JR, Kofoed L, Tervo R, Fogas B, Wilson A, Fiechtner H (1998) Effectiveness of methylphenidate in native American children with fetal alcohol syndrome and attention deficit/hyperactivity disorder: a controlled pilot study. J Child Adolesc Psychopharmacol 8:39–48 CrossRef Oesterheld JR, Kofoed L, Tervo R, Fogas B, Wilson A, Fiechtner H (1998) Effectiveness of methylphenidate in native American children with fetal alcohol syndrome and attention deficit/hyperactivity disorder: a controlled pilot study. J Child Adolesc Psychopharmacol 8:39–48 CrossRef
27.
go back to reference O’Malley KD, Koplin B, Dohner VA (2000) Psychostimulant clinical response in fetal alcohol syndrome. Can J Psychiatry 45:90–91 PubMed O’Malley KD, Koplin B, Dohner VA (2000) Psychostimulant clinical response in fetal alcohol syndrome. Can J Psychiatry 45:90–91 PubMed
28.
go back to reference Doig J, McLennan JD, Gibbard WB (2008) Medication effects on symptoms of attention-deficit/hyperactivity disorder in children with fetal alcohol spectrum disorder. J Child Adolesc Psychopharmacol 18:365–371 CrossRef Doig J, McLennan JD, Gibbard WB (2008) Medication effects on symptoms of attention-deficit/hyperactivity disorder in children with fetal alcohol spectrum disorder. J Child Adolesc Psychopharmacol 18:365–371 CrossRef
29.
go back to reference Snyder JNJ, Snyder R, Block G (1997) A study of stimulant medication in children with FAS. In: Streissguth AKJ (ed) Overcoming and preventing secondary disabilities in fetal alcohol syndrome and fetal alcohol effects. University of Washington Press, Seattle, WA, pp 64–77 Snyder JNJ, Snyder R, Block G (1997) A study of stimulant medication in children with FAS. In: Streissguth AKJ (ed) Overcoming and preventing secondary disabilities in fetal alcohol syndrome and fetal alcohol effects. University of Washington Press, Seattle, WA, pp 64–77
30.
go back to reference Coe JSJ, Riley K, Waltermire J, Hagerman R (2001) A survey of medication responses in children and adolescents with fetal alcohol syndrome. Ment Health Aspect Develop Disabilities 4:148–155 Coe JSJ, Riley K, Waltermire J, Hagerman R (2001) A survey of medication responses in children and adolescents with fetal alcohol syndrome. Ment Health Aspect Develop Disabilities 4:148–155
31.
go back to reference Wozniak JR, Fuglestad AJ, Eckerle JK, Fink BA, Hoecker HL, Boys CJ et al (2015) Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 102:1113–1125 CrossRef Wozniak JR, Fuglestad AJ, Eckerle JK, Fink BA, Hoecker HL, Boys CJ et al (2015) Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 102:1113–1125 CrossRef
32.
go back to reference Nguyen TT, Risbud RD, Mattson SN, Chambers CD, Thomas JD (2016) Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders. Am J Clin Nutr 104:1683–1692 CrossRef Nguyen TT, Risbud RD, Mattson SN, Chambers CD, Thomas JD (2016) Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders. Am J Clin Nutr 104:1683–1692 CrossRef
33.
go back to reference Srivastava A, Coffey B (2014) Emotional dysregulation in a child with attention-deficit/hyperactivity disorder and anxiety: psychopharmacological stategies. J Child Adolesc Psychopharmacol 24:590–593 CrossRef Srivastava A, Coffey B (2014) Emotional dysregulation in a child with attention-deficit/hyperactivity disorder and anxiety: psychopharmacological stategies. J Child Adolesc Psychopharmacol 24:590–593 CrossRef
34.
go back to reference Hanlon-Dearman A, Chen ML, Olson HC (2018) Understanding and managing sleep disruption in children with fetal alcohol spectrum disorder. Biochem Cell Biol 96:267–274 CrossRef Hanlon-Dearman A, Chen ML, Olson HC (2018) Understanding and managing sleep disruption in children with fetal alcohol spectrum disorder. Biochem Cell Biol 96:267–274 CrossRef
35.
go back to reference Mela M, Okpalauwaekwe U, Anderson T, Eng J, Nomani S, Ahmed A et al (2018) The utility of psychotropic drugs on patients with fetal alcohol spectrum disorder (FASD): a systematic review. Psychiatr Clin Psychopharmacol 28:436–445 CrossRef Mela M, Okpalauwaekwe U, Anderson T, Eng J, Nomani S, Ahmed A et al (2018) The utility of psychotropic drugs on patients with fetal alcohol spectrum disorder (FASD): a systematic review. Psychiatr Clin Psychopharmacol 28:436–445 CrossRef
Metagegevens
Titel
Psychopharmacological Treatments in Children with Fetal Alcohol Spectrum Disorders: A Review
Auteurs
Gaby J. Ritfeld
Julie A. Kable
Jennifer E. Holton
Claire D. Coles
Publicatiedatum
27-01-2021
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 2/2022
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-021-01124-7