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01-07-2012 | Original Paper | Uitgave 7/2012

Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 7/2012

Auteurs:: Stephanie M. Sansone, Keith F. Widaman, Scott S. Hall, Allan L. Reiss, Amy Lightbody, Walter E. Kaufmann, Elizabeth Berry-Kravis, Ave Lachiewicz, Elaine C. Brown, David Hessl

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Electronic supplementary material

The online version of this article (doi:10.1007/s10803-011-1370-2) contains supplementary material, which is available to authorized users.

A portion of the data was presented at the 44th Annual Gatlinburg Conference, San Antonio, TX, in March 2010.

Abstract

Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3–25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.

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Titel: Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment
Auteurs:: Stephanie M. Sansone
Keith F. Widaman
Scott S. Hall
Allan L. Reiss
Amy Lightbody
Walter E. Kaufmann
Elizabeth Berry-Kravis
Ave Lachiewicz
Elaine C. Brown
David Hessl
Publicatiedatum: 01-07-2012
DOI: https://doi.org/10.1007/s10803-011-1370-2
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 7/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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