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01-07-2012 | Original Paper

Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment

Auteurs: Stephanie M. Sansone, Keith F. Widaman, Scott S. Hall, Allan L. Reiss, Amy Lightbody, Walter E. Kaufmann, Elizabeth Berry-Kravis, Ave Lachiewicz, Elaine C. Brown, David Hessl

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2012

Abstract

Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3–25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.

vorige artikel Moral and Social Reasoning in Autism Spectrum Disorders

volgende artikel Emotional and Behavioral Adjustment in Typically Developing Siblings of Children with Autism Spectrum Disorders

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Titel: Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment
Auteurs: Stephanie M. Sansone
Keith F. Widaman
Scott S. Hall
Allan L. Reiss
Amy Lightbody
Walter E. Kaufmann
Elizabeth Berry-Kravis
Ave Lachiewicz
Elaine C. Brown
David Hessl
Publicatiedatum: 01-07-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 7/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-011-1370-2

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