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Gepubliceerd in: Quality of Life Research 5/2017

20-10-2016

Proxy-reported quality of life in adolescents and adults with dyskinetic cerebral palsy is associated with executive functions and cortical thickness

Auteurs: O. Laporta-Hoyos, J. Ballester-Plané, P. Póo, A. Macaya, M. Meléndez-Plumed, E. Vázquez, I. Delgado, L. Zubiaurre-Elorza, V. L. Botellero, A. Narberhaus, E. Toro-Tamargo, D. Segarra, R. Pueyo

Gepubliceerd in: Quality of Life Research | Uitgave 5/2017

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Abstract

Purpose

Quality of life (QOL) is a key outcome for people with cerebral palsy (CP), and executive functioning is an important predictor of QOL in other health-related conditions. Little is known about this association in CP or about its neural substrate. We aim to analyze the influence of executive functioning (including cognitive flexibility) as well as that of other psychological, motor, communication and socioeconomic variables on QOL and to identify neuroanatomical areas related to QOL in adolescents and adults with CP.

Methods

Fifty subjects diagnosed with dyskinetic CP (mean age 25.96 years) were recruited. Their caregivers completed the primary caregiver proxy report version of the CP QOL-Teen questionnaire. Motor status, communication, IQ, four executive function domains, anxiety/depression and socioeconomic status were evaluated. Correlations and multiple linear regression models were used to relate CP QOL domains and total score to these variables. Thirty-six participants underwent an MRI assessment. Correlations were examined between cortical thickness and CP QOL total score and between cortical thickness and variables that might predict the CP QOL total score.

Results

Executive functions predict scores in four domains of CP QOL (General well-being and participation, Communication and physical health, Family health and Feelings about functioning) in the regression model. Among the cognitive domains that comprise executive function, only cognitive flexibility measured in terms of performance on the Wisconsin card sorting test (WCST) predicts the CP QOL total score. Monthly income, fine motor functioning and communication ability predict scores on the domains Access to services and Family Health, Feelings about functioning and School well-being, respectively. The clusters resulting from the correlation between cortical thickness and both CP QOL total score and WCST performance overlapped in the posterior cingulate and precuneus cortices.

Conclusions

Cognitive flexibility predicts proxy report CP QOL-Teen total score in dyskinetic CP. This relationship has its anatomical correlate in the posterior cingulate and precuneus cortices.
vorige artikel Employing quality control and feedback to the EQ-5D-5L valuation protocol to improve the quality of data collection
volgende artikel Investigating acculturation orientations of patients with an immigration background and doctors in Canada: implications for medical advice adherence
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Metagegevens
Titel
Proxy-reported quality of life in adolescents and adults with dyskinetic cerebral palsy is associated with executive functions and cortical thickness
Auteurs
O. Laporta-Hoyos
J. Ballester-Plané
P. Póo
A. Macaya
M. Meléndez-Plumed
E. Vázquez
I. Delgado
L. Zubiaurre-Elorza
V. L. Botellero
A. Narberhaus
E. Toro-Tamargo
D. Segarra
R. Pueyo
Publicatiedatum
20-10-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 5/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1433-0

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