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Gepubliceerd in: Journal of Foot and Ankle Research 1/2015

Open Access 01-12-2015 | Review

Protective socks for people with diabetes: a systematic review and narrative analysis

Auteurs: Simon J Otter, Keith Rome, Belinda Ihaka, Andrew South, Mandy Smith, Amit Gupta, Frances Joseph, Peter Heslop

Gepubliceerd in: Journal of Foot and Ankle Research | Uitgave 1/2015

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Abstract

Padded socks to protect the at-risk diabetic foot have been available for a number of years. However, the evidence base to support their use is not well known. We aimed to undertake a systematic review of padded socks for people with diabetes. Additionally, a narrative analysis of knitted stitch structures, yarn and fibres used together with the proposed benefits fibre properties may add to the sock. Assessment of the methodological quality was undertaken using a quality tool to assess non-randomised trials. From the 81 articles identified only seven met the inclusion criteria. The evidence to support to use of padded socks is limited. There is a suggestion these simple-to-use interventions could be of value, particularly in terms of plantar pressure reduction. However, the range of methods used and limited methodological quality limits direct comparison between studies. The socks were generally of a sophisticated design with complex use of knit patterns and yarn content. This systematic review provides limited support for the use of padded socks in the diabetic population to protect vulnerable feet. More high quality studies are needed; including qualitative components of sock wear and sock design, prospective randomized controlled trials and analysis of the cost-effectiveness of protective socks as a non-surgical intervention.
Opmerkingen

Electronic supplementary material

The online version of this article (doi:10.​1186/​s13047-015-0068-7) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

Simon Otter Developed and performed the search, undertook systematic review and prepared manuscript, Keith Rome Conceived idea and prepared manuscript, Belinda Ihaka Manuscript preparation, Andrew Smith Developed and performed the search, Mandy Smith Performed narrative analysis of sock design & composition & prepared manuscript, Amit Gupta Performed narrative analysis of sock design & composition & prepared manuscript, Francis Joseph Conceived idea, Peter Heslop Conceived idea. All authors read and approved the final manuscript.

Authors’ information

SO Research Fellow, KR Professor of Podiatry, BI Lecturer, AS Librarian, MS Senior Lecturer, AG Researcher, FJ Assistant Professor, PH Manager Textile and Design Laboratory.

Introduction

Diabetes mellitus, particularly the mature onset or type-two variation (T2DM) is a major health concern world-wide [1-3]. T2DM is a cause of significant co-morbidity and is predicted to further increase over the next 20 years contributing to a greater diabetes-related burden [1,4-6]. Some 15%-25% of people with diabetes will suffer a foot ulcer [7,8] and limb amputation is preceded by foot ulceration in 85% of cases [9]. More worryingly it is suggested that some 80% of amputations are preventable [10]. The aetiology of foot ulcers is complex and has been extensively reviewed [11-14]. Complications (including vascular disease, peripheral neuropathy, increased mechanical stress and Charcot neuroarthropathy) greatly increase the incidence of lower limb amputations [14-17]. However, the nature of diabetes means even those at low risk can develop foot complications [18], particularly in the presence of poor glycaemic control and/or a lack of regular foot assessment. Foot complications negatively impact individuals’ quality of life and their ability to be productive members of society and these complex pathologies are a considerable health system burden [19-21].
A range of non-surgical approaches can be used to prevent the foot complications seen in diabetes including education, self-care/self-monitoring of feet, appropriate skin and nail care, wearing supportive footwear and protective socks, as well as formal podiatric assessment and treatment [22-24]. From a commercial perspective a vast range of protective socks are commercially available (Additional file 1). Recent studies in diabetic foot ulcer prevention have reported on foot orthoses and footwear to reduce foot pressure [25,26]. A systematic review [27] considered ‘socks for people with diabetes’ but did not present any formal scoring, yet determined results for this type of hosiery were inconclusive. A recent Cochrane review appraised off-loading strategies, but did not include protective socks [28]. Therefore, we sought to undertake a systematic review of protective socks for people with diabetes and included a narrative analysis of these socks, which included an analysis of the knitted stitch structure and yarn/fibre type.

Review

Methods

This systematic review was undertaken according to the guidelines provided by the Cochrane Collaboration [29] and the PRISMA group [30].

Search and selection process

To obtain all articles relating to the use of socks for people with diabetes an extensive literature search was designed jointly by the lead author (SO) and an experienced librarian (AS) performed across several databases EBSCO (Biomedical reference collection, Cinhal, Health business elite, Health source, Medline, Sport discuss) SCOPUS, AMED, Cochrane and PEDro. Databases were searched from 1985 – 2014, as socks for people with diabetes were not available prior to 1985. Further searches of manufacturer’s websites were also conducted.
Publications were identified through a search that used the following MeSh terms: (diabet* AND sock) OR (diabet* AND socks) OR (diabet* AND hosiery) OR (diabet* AND padded). Articles were limited to “humans” and “English”. Inclusion criteria comprised articles reporting any type of clinical trial design, including people with diabetes reporting the use of socks for people with diabetes. Articles were initially excluded if they did not report diabetes; did not focus on socks for people with diabetes as a mechanism for foot protection reduction, (for example articles reporting the use of hosiery to control oedema). Articles relating to non-diabetic groups, for example, healthy populations or sports were also excluded. Owing to a paucity of high quality research, studies were included if they were of level four or above [31] and in English language. Reviews, editorials, letters and single case histories were excluded. The selection process was performed on the titles of articles, the abstract then on full text (Figure 1).

General data extraction

Publications were evaluated based on the full text article and reviewers were not blinded to the journal title or authors. Information was extracted based on year of publication, study design and number of participants. Demographic data such as gender, age, duration of diabetes, disease features and length of follow-up was also recorded. Publications were reviewed with the use of a tool developed by Downs & Black [32]. While the Cochrane Collaboration [29] does not recommend a specific tool for non-randomised clinical trials, this instrument has been widely used for non-pharmacological trials and provides a score between 0-32 across 27 questions: a higher score representing robust, high quality methodology. The tool is easy to complete with high internal consistency, test-retest and inter-rater reliability reported to be good by the authors [32]. The checklist covers study quality (10 items), external validity (3 items), bias (7 items), confounding and selection bias (6 items) and the power of the study (1 item) [33].

Statistical Analysis

Analysis was mainly descriptive based on an analysis of the narrative provided by studies, i.e. the extent to which plantar pressures were reduced; together with the Downs and Black score for each article. In this review four questions (7, 15, 16 and 25) were omitted from the Downs & Black tool as these were not applicable to any of the trials being reviewed. Each score is therefore expressed as a percentage to permit ease of comparison.

Description of publications

A total of 81 articles were retrieved, but we identified only seven prospective studies [34-40] that met the inclusion criteria. A further five papers [41-45] considered the role of protective socks in other populations (e.g. athletes’ or rheumatoid arthritis). While these findings may be transferrable to the diabetic population, they were excluded from the review. From the additional 70 articles that were excluded, many were duplicates (n = 23). Others were industry reports highlighting new product developments (n = 12), but not providing any empirical evidence to support the product (Figure 1). A further 18 papers consisted of education and/or continuing professional development articles for health professionals highlighting the need to protect the ‘at risk’ diabetic foot. Of the seven studies included, three were case series, three cross sectional designs and one single blind RCT. The main characteristics of the studies reviewed are presented in Table 1. The mean quality score was 39% (SD 20, range 17-78%) - details in Table 2.
Table 1
Overview of studies reviewed
Study
Demographic data
Inclusion criteria (in addition to diabetes)
Findings
Blackwell et al. [34]
N° of subjects 21
Diabetes with foot complaints, no active ulceration
Plantar pressure assessed with Parotec system
Gender 10 M : 11 F
Mean age (range) 57.4 (20-83)
No significant difference between JBOST diabetic sock, normal sock or barefoot
Diabetes duration Not stated
Veves et al. [35]
N° of subjects 27
High plantar pressures (>10 kg/cm2)
Plantar pressure assessed with optical pedobarograph
Gender 15 M: 2 F
Neuropathy (diminished nerve conduction & vibration perception)
Experimental socks [Thorlo] provided significant pressure reduction compared with pts own socks or barefoot (both p < 0.001)
Mean age (range) 54 (26-74)
Diabetes duration not stated
Able walk unaided, no PVD, no ulcer history
Veves et al. [36]
Gender not stated
Neuropathy (diminished vibration perception & absent ankle reflex)
Plantar pressure assessed with optical pedobarograph
Experimental group (n = 10)
mean age (range) 51.3 (27-65)
Duration of diabetes not stated
Significant reduction in pressure of experimental socks [Thorlo] compared with padded sports socks & barefoot (all p < 0.001). Pressure reduction maintained by experimental socks at 3 & 6 months.
Control group n = 16
Mean age (range) 55.8 (33-70)
Garrow et al. [37]
N° of subjects 19
Neuropathy (neuropathy disability score >5 or diminished vibration perception ≥25).
Plantar pressure assessed with F-scan system
Gender 15 M:4 F
Mean age (range) 65.5 (39-80)
Ulcer-free at recruitment
Preventative Foot Care Diabetic socks provided significant increase in foot contact area (p < 0.01), a reduction total pressure (p < 0.01).
Diabetes duration median 20 yrs
High plantar pressure (≥6 kg/cm2).
Murray et al. [38]
N° of subjects 86
Neuropathy (diminished pressure or vibration perception)
Questionnaire based satisfaction survey over 6 month period using Thorlo socks
Gender 69 M :17 F
Mean age (range) 63 (34-85)
No active ulceration
Socks reported good/very good by 86%, average by 12% & poor by 3%.
Mean diabetes (range) 16 (1–45 yrs
84% reported continue sock use at 3 & 6 months
Banchellini et al. [39]
N° of subjects 30
Peripheral neuropathy (ADA criteria)
Skin parameters tested:
Gender not stated
Hydration (hydration score) Hardness (Durometer)
Group A (Difoprev) socks
Anhidrosis (Clinical features & Neuropad test)
Moisture loss (Scalar moisture checker)
Mean age 59.6 (SD13.8)
Water loss (TEWL vapometer)
Duration diabetes 16.1 (SD9)
No active ulceration, ABPI >0.9, Serum creatinine >2 mg/dL
All skin parmeters improved over 6 week trial (Difoprev) socks & normal socks
Group B (no active sock ingredient)
Mean age 61.4 (SD15.5)
Skin hydration p < 0.01 Skin hardness p <0.05
Duration diabetes 15.7 (SD6.9)
No systemic skin disease, no B-blocker therapy
Controls (normal socks)
Skin moisture loss p < 0.01 Skin water loss p < 0.01
Mean age 60.5 (SD11.4)
Yick et al. [40]
No of subjects 4
No inclusion criteria stated
Plantar pressure (Pedar system)
Gender not stated
Skin temperature & humidity (system not stated)
Age not stated
Socks tested not stated
Diabetes duration not stated
Considerable pressure reduction stated but not per sock type
Thermal properties are stated but not compared between socks or post sock wear
Table 2
Description of scoring based on Downs & Black criteria
Study
Is the aim of the study clear?
Are the main outcomes clearly described?
Are characteristics of patients included clearly described?
Are the interventions clearly described?
Are co-founders clearly described?
Are the main findings clearly described?
Have adverse events been reported?
Are subjects lost to follow up characteristics reported?
Are actual probability values reported?
Were subjects invited representative of population
Subjects who participated representative of population?
Were staff, places & facilities representative?
Was there an attempt to blind study subjects?
Were analyses adjusted for different lengths of follow-up between interventions?
Were appropriate Statistical tests used?
Was compliance with interventions reliable?
Were main outcome measures accurate and reliable?
Were cases/controls recruited from same population?
Were cases/controls recruited over same time?
Were subjects randomized to intervention groups?
Was randomized intervention concealed form subjects & clinicians?
Are analyses adjusted for lost to follow up subjects
Study have sufficient power to detect clinically important effect?
Total score (%) based on 23 items
Veves et al. [37]
X
X
X
X
O
O
X
U
O
U
X
X
O
U
X
X
X
U
U
U
U
U
O
10 (43.5%)
Veves et al. [38]
X
X
X
X
O
X
X
U
O
U
U
X
O
O
X
X
X
U
U
U
U
U
O
10 (43.5%)
Murray et al. [40]
X
O
X
X
X
O
X
U
O
U
U
U
O
U
U
X
U
U
U
U
U
U
U
6 (26.1%)
Blackwell et al. [36]
X
O
O
X
O
O
O
O
O
U
U
U
O
U
X
X
X
U
U
U
U
O
O
5 (21.8%)
Garrow et al. [39]
X
X
X
X
X
X
U
O
O
U
U
X
O
U
U
U
X
U
U
X
O
O
U
9 (39.2%)
Banchellini et al. [41]
X
X
X
X
X
X
X
U
O
X
X
X
X
X
X
X
X
X
X
X
O
U
U
18 (78.3%)
Yick et al. [42]
X
X
O
X
O
O
O
U
O
U
U
U
O
O
U
U
X
U
U
U
U
U
O
4 (17.4%)
X = yes, O = no, U = unable to tell.
Questions omitted: 7 - no trials reported the random variability for their main outcomes, 15 - none of the studies were double-blind, 16 - there was no evidence of data dredging, 25 - cofounding variables were not adjusted for throughout.

Plantar foot pressure

Five studies [34-38,40] used peak plantar pressure as the primary outcome measure. A variety of protective socks were included. Additionally, most studies also included a control element with subjects using their own socks or standard shop-bought socks together with barefoot pressure measurements as a true control condition. Three studies [35-37] reported padded socks provided a significant reduction in peak plantar pressure. They suggest that in conjunction with wearing proper footwear/orthoses, padded socks could help prevent foot ulcer formation. However, one study [34] reported an increase in peak plantar pressure with padded socks. One study reported a follow-up period [36] and a significant reduction in peak plantar pressure was maintained at 6 months, although this reduction was not as great as was seen at baseline.

Plantar contact area

One study [40] reported plantar contact area as an outcome and reported a significantly greater contact area with socks for people with diabetes compared with ordinary shop-bought socks. These authors demonstrated an increase in maximum foot contact area of 11 cm2 when subjects wore the protective socks, accompanied by a 9% reduction in total foot pressure. Similar results were observed at the forefoot, a 14% increase in contact area and 10% reduction in peak forefoot pressure.

Patient satisfaction

One study used a survey design approach to quantify how satisfied subjects were with socks designed to reduce pressure over a 6-month period [41]. The results were positive; with 85% reporting high satisfaction, and 84% of participants reported they wished to continue wearing the socks after the trial.

Skin moisture and temperature

Banchellini et al. [39] reported in a 6-week randomised trial into a new nanotechnology impregnated sock design intended to increase skin moisture content. The sock (Difoprev system, LVM technologies Italy) consisted of a synthetic polyammide fibre loaded with microcapsules of an emollient agent. Additionally, Yick et al. [40] noted an increase in skin temperature and humidity with protective socks in a sample of two subjects with diabetes.
From this review there is weak evidence that protective socks may reduce foot pressures and provide additional protection for the at-risk foot in diabetes. There are four domains (plantar pressure, plantar contact area, satisfaction and skin moisture) that reflect relevant clinical outcomes and are reported in research articles over 25 years. However, in spite of sophisticated sock design and material usage employed by manufacturers, studies received low scores using the Downs and Black instrument. The majority of studies compared very small populations and were not adequately powered. This together with limitations in the overall design (e.g. lack of randomization, blinding of participants and/or clinicians) also contributed to low scores. While it is difficult to blind clinicians working in healthcare settings, the guidance offered by Boultron et al. [46] and Cook [47] are essential as a lack of non-blinded assessors can cause a high risk of observer bias [48]. In most studies some attempt was made to identify participants with diabetes who would benefit more from protective socks (i.e. those with higher plantar pressures and loss of protective sensation), which might also suggest greater improvements would be reported. However, not all articles controlled for the complications commonly seen in diabetes (e.g. vascular disease, current foot ulceration or previous amputation). While this may represent the heterogeneous nature of foot complaints seen in diabetes, equally there were no clear attempts to include adequate numbers of subjects with these complications to represent the heterogeneous nature of foot complaints seen in the diabetic population. Moreover, the contention of many articles was that reducing foot pressure would prevent foot ulceration. However, the incidence of foot ulceration was not a primary outcome measure and not always stated as an adverse event.
Plantar pressures have long been recommended as a key outcome measure to identify those at risk of foot ulceration [17,49]. Notably, up to three-quarters of foot ulcers are over the metatarsal head region [50] – often an area of high pressure. Ulbrect et al. [26] report that peak barefoot plantar pressure is the key determinant when manufacturing bespoke orthoses to off-load pressure. A significant reduction in plantar pressure was reported by three studies while using protective socks [35-37]. However, considerable variations between peak plantar pressure values have also been reported for those with and without foot ulcers [26,51,52]. These differences may be due to a number of factors, including the protocol and equipment used. In the articles we reviewed, research protocols were often not clearly described. That said, many were published prior to the development of guidelines for plantar pressure studies [53]. Additionally, footwear is often a key therapeutic intervention; [27,54] so controlling for, or standardising footwear should also be a consideration when designing research protocols when testing protective socks. Foot structure, biomechanics and tissue glycation may have a marked effect on plantar pressure variables [55-57] and these variables should also be considered either as part of the exclusion criteria or as potential confounders when assessing the impact of protective socks on plantar pressures.
Satisfaction and concordance with interventions is a key area for research, as patients are unlikely to continue to wear socks they are unhappy with or find uncomfortable. Only one study [38] addressed this important aspect of practice, but the instrument used to determine satisfaction was not provided, making an adequate assessment of its appropriateness, responsiveness and reliability difficult. Any changes in clinical outcomes (e.g. a reduction in plantar pressure) that may have occurred during the study period was not reported.
From the narrative analysis of articles and website data, all socks reviewed were knitted using a weft knit method with a variety of yarns (Additional file 1). We noted sophisticated sock designs that included the use of pile fabric knit structures over areas requiring extra padding to reduce pressure, rib knit structures used to provide compression and support structure over the ankle and mesh or tuck knit structures allowing for free ventilation where less protection and greater flexibility is needed. Bertaux et al. [58] reported significant correlations between physiological and sensory parameters as well as between fabric friction and perceived comfort in eleven subjects wearing sports socks. This highlights that ‘comfortable’ socks provide lower friction coefficients and hence reduce the potential for skin damage. Maximising protection and reducing friction at the foot/sock interface is thought to be key for preventing lesions in the at-risk diabetic foot [59]. However, parameters such as shear and temperature were typically not comprehensively studied in the articles we reviewed. While not a padded sock per se, the Difoprev system reported by Banchelline et al. [39] provided a significant increase in skin hydration. A decrease in moisture loss, water loss and hardness is of value to people with insensate feet, where autonomic neuropathy in particular is known to cause excessive dryness and is a risk factor for foot ulceration [13,60].
This paper represents the first review to combine a systematic review on a topic that has not been previously addressed, together with a narrative analysis of the key intervention. There are some limitations to consider. Ideally a meta-analysis would be conducted in conjunction with this systematic review. However, this was not possible as the studies using plantar pressure analysis (the primary outcome in the majority of studies) were conducted with various systems to measure foot pressure. This results in different spatial and temporal resolutions, data extraction and management approaches. Additionally, the main plantar pressure variable was reported differently throughout. These factors make comparisons between trials difficult and not conducive to further statistical analysis.

Conclusion

Altering the socks people with diabetes wear could provide a simple, cosmetically acceptable, and potentially cost-effective method of protecting the at-risk foot in diabetes. However, the previous studies of protective socks were often poorly controlled, underpowered and did not justify the primary outcomes reported. Consequently, there are opportunities for further research, including qualitative components of sock wear and sock design, together with randomized controlled trials and analysis of cost-effectiveness.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
The Creative Commons Public Domain Dedication waiver (https://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

Simon Otter Developed and performed the search, undertook systematic review and prepared manuscript, Keith Rome Conceived idea and prepared manuscript, Belinda Ihaka Manuscript preparation, Andrew Smith Developed and performed the search, Mandy Smith Performed narrative analysis of sock design & composition & prepared manuscript, Amit Gupta Performed narrative analysis of sock design & composition & prepared manuscript, Francis Joseph Conceived idea, Peter Heslop Conceived idea. All authors read and approved the final manuscript.

Authors’ information

SO Research Fellow, KR Professor of Podiatry, BI Lecturer, AS Librarian, MS Senior Lecturer, AG Researcher, FJ Assistant Professor, PH Manager Textile and Design Laboratory.
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Literatuur
2.
go back to reference Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–53.CrossRefPubMed Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–53.CrossRefPubMed
3.
go back to reference Coppell KJ, Mann JI, Williams SM, Jo E, Dury PL, Miller JC, Parnell WR. Prevalence of diagnosed and undiagnosed diabetes and prediabetes in New Zealand: findings from the 2008/09 Adult Nutrition Survey. NZMJ [serial on the Internet] 2013;126:1370. Available at: https://www.nzma.org.nz/journal. Coppell KJ, Mann JI, Williams SM, Jo E, Dury PL, Miller JC, Parnell WR. Prevalence of diagnosed and undiagnosed diabetes and prediabetes in New Zealand: findings from the 2008/09 Adult Nutrition Survey. NZMJ [serial on the Internet] 2013;126:1370. Available at: https://​www.​nzma.​org.​nz/​journal.
4.
go back to reference Armstrong DG, Cohen K, Courric S, Bharara M, Marston W. Diabetic foot ulcers and vascular insufficiency: our population has changed, but our methods have not. J Diabetes Sci Technol. 2011;5(6):1591–5.CrossRefPubMedPubMedCentral Armstrong DG, Cohen K, Courric S, Bharara M, Marston W. Diabetic foot ulcers and vascular insufficiency: our population has changed, but our methods have not. J Diabetes Sci Technol. 2011;5(6):1591–5.CrossRefPubMedPubMedCentral
5.
go back to reference Joshy G, Kamalinie C, Dunn P, Simmons D, Lawrenson R. Ethnic disparities in causes of death among diabetes patients in the Waikato region of New Zealand. NZMJ [serial on the Internet] 123:1310. Available at: https://www.nzma.org.nz/journal. Joshy G, Kamalinie C, Dunn P, Simmons D, Lawrenson R. Ethnic disparities in causes of death among diabetes patients in the Waikato region of New Zealand. NZMJ [serial on the Internet] 123:1310. Available at: https://​www.​nzma.​org.​nz/​journal.
7.
go back to reference Frykberg RG, Zgonis T, Armstrong DG, Driver VR, Giurini JM, Kravitz SR, et al. Diabetic Foot disorders a clinical practice guide. J Foot Ankle Surg. 2006;45(5):S1–66.CrossRefPubMed Frykberg RG, Zgonis T, Armstrong DG, Driver VR, Giurini JM, Kravitz SR, et al. Diabetic Foot disorders a clinical practice guide. J Foot Ankle Surg. 2006;45(5):S1–66.CrossRefPubMed
8.
go back to reference Reiber GE. Epidemiology of foot ulcers and amputations in the diabetic foot. In: Bowker JH, Pfeifer MA, editors. The Diabetic Foot. St Louis: Mosby; 2001. p. 13–32. Reiber GE. Epidemiology of foot ulcers and amputations in the diabetic foot. In: Bowker JH, Pfeifer MA, editors. The Diabetic Foot. St Louis: Mosby; 2001. p. 13–32.
9.
go back to reference Boyko EJ, Ahroni JH, Stensel V, Frosberg RC, Davignon DR, Smith DG. A prospective study of risk factors for diabetic foot ulcer: the Seattle Diabetic Foot study. Diabetes Care. 1999;22:1036–42.CrossRefPubMed Boyko EJ, Ahroni JH, Stensel V, Frosberg RC, Davignon DR, Smith DG. A prospective study of risk factors for diabetic foot ulcer: the Seattle Diabetic Foot study. Diabetes Care. 1999;22:1036–42.CrossRefPubMed
11.
go back to reference Pecoraro RE, Reiber GE, Burgess EM. Pathways to diabetic limb amputation. Basis for prevention. Diabetes Care. 1990;13:513–21.CrossRefPubMed Pecoraro RE, Reiber GE, Burgess EM. Pathways to diabetic limb amputation. Basis for prevention. Diabetes Care. 1990;13:513–21.CrossRefPubMed
12.
go back to reference Reiber GE, Vileikyte L, Boyko EJ, del Aguila M, Smith DG, Lavery LA, et al. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care. 1999;22:157–62.CrossRefPubMed Reiber GE, Vileikyte L, Boyko EJ, del Aguila M, Smith DG, Lavery LA, et al. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care. 1999;22:157–62.CrossRefPubMed
13.
14.
go back to reference Alavi A, Sibbald RG, Mayer D, Goodman L, Botros M, Armstrong DG, Woo K, Boeni T, Ayello EA, Kirsner RS. Diabetic foot ulcers: Part I: Pathophysiology and prevention. J Am Acad Dermatol. [On-line serial] 2014;70(1):1.e1-e18. Available at: http://www.eblue.org/ Alavi A, Sibbald RG, Mayer D, Goodman L, Botros M, Armstrong DG, Woo K, Boeni T, Ayello EA, Kirsner RS. Diabetic foot ulcers: Part I: Pathophysiology and prevention. J Am Acad Dermatol. [On-line serial] 2014;70(1):1.e1-e18. Available at: http://​www.​eblue.​org/​
15.
go back to reference Haris M, Rathur HM, Boulton AJM. The diabetic foot. Clin Dermatol. 2007;25:109–20.CrossRef Haris M, Rathur HM, Boulton AJM. The diabetic foot. Clin Dermatol. 2007;25:109–20.CrossRef
16.
go back to reference Moxey PW, Gogalniceanu P, Hinchliffe RJ, Loftus IM, Jones KJ, Thompson MM, et al. Lower extremity amputations–a review of global variability in incidence. Diabet Med. 2011;28(10):1144–53.CrossRefPubMed Moxey PW, Gogalniceanu P, Hinchliffe RJ, Loftus IM, Jones KJ, Thompson MM, et al. Lower extremity amputations–a review of global variability in incidence. Diabet Med. 2011;28(10):1144–53.CrossRefPubMed
17.
go back to reference Boulton AJ, Armstrong DG, Albert SF, Frykberg RG, Hellman R, Kirkman MS, et al. Comprehensive foot examination and risk assessment: a report of the task force of the foot care interest group of the American Diabetes Association, with endorsement by the American Association of Clinical Endocrinologists. Diabetes Care. 2008;31(8):1679–85.CrossRefPubMedPubMedCentral Boulton AJ, Armstrong DG, Albert SF, Frykberg RG, Hellman R, Kirkman MS, et al. Comprehensive foot examination and risk assessment: a report of the task force of the foot care interest group of the American Diabetes Association, with endorsement by the American Association of Clinical Endocrinologists. Diabetes Care. 2008;31(8):1679–85.CrossRefPubMedPubMedCentral
19.
go back to reference Ortegon MM, Redekop WK, Niessen LW. Cost-effectiveness of prevention and treatment of the diabetic foot: a Markov analysis. Diabetes Care. 2004;27:901–7.CrossRefPubMed Ortegon MM, Redekop WK, Niessen LW. Cost-effectiveness of prevention and treatment of the diabetic foot: a Markov analysis. Diabetes Care. 2004;27:901–7.CrossRefPubMed
20.
go back to reference Driver VR, Fabbi M, Lavery LA, Gibbons G. The costs of diabetic foot: the economic case for the limb salvage team. J Vasc Surg. 2010;52(Suppl):17S–22.CrossRefPubMed Driver VR, Fabbi M, Lavery LA, Gibbons G. The costs of diabetic foot: the economic case for the limb salvage team. J Vasc Surg. 2010;52(Suppl):17S–22.CrossRefPubMed
21.
go back to reference Kerr M, Rayman G, Jeffcoate WJ. Cost of diabetic foot disease to the National Health Service in England. Diabetic Med. (Advance online publication): 2014. Available at: doi:10.1111/dme.12545. Kerr M, Rayman G, Jeffcoate WJ. Cost of diabetic foot disease to the National Health Service in England. Diabetic Med. (Advance online publication): 2014. Available at: doi:10.1111/dme.12545.
22.
go back to reference Mayfield JA, Reiber GE, Sanders LJ, Janisse D, Pogach LM. Preventive foot care in diabetes. Diabetes Care. 2004;27 Suppl 1:S63–4.PubMed Mayfield JA, Reiber GE, Sanders LJ, Janisse D, Pogach LM. Preventive foot care in diabetes. Diabetes Care. 2004;27 Suppl 1:S63–4.PubMed
23.
go back to reference McInnes A, Jeffcoate W, Vileikyte L, Game F, Lucas K, Higson N, et al. Foot care education in patients with diabetes at low risk of complications: a consensus statement. Diabet Med. 2011;28(2):162–7.CrossRefPubMedPubMedCentral McInnes A, Jeffcoate W, Vileikyte L, Game F, Lucas K, Higson N, et al. Foot care education in patients with diabetes at low risk of complications: a consensus statement. Diabet Med. 2011;28(2):162–7.CrossRefPubMedPubMedCentral
24.
go back to reference National Institute for Health and Clinical Excellence. Diabetic foot problems: Evidence Update March 2013: A summary of selected new evidence relevant to NICE clinical guideline 119 ‘Inpatient management of diabetic foot problems’. 2011. Available at: http://www.nice.org.uk/guidance/cg119. National Institute for Health and Clinical Excellence. Diabetic foot problems: Evidence Update March 2013: A summary of selected new evidence relevant to NICE clinical guideline 119 ‘Inpatient management of diabetic foot problems’. 2011. Available at: http://​www.​nice.​org.​uk/​guidance/​cg119.
25.
go back to reference Bus SA, Waaijman R, Arts M, de Haart M, Busch-Westbroek T, van Baal J, et al. Effect of custom-made footwear on foot ulcer recurrence in diabetes: a multicenter randomized controlled trial. Diabetes Care. 2013;36(12):4109–16.CrossRefPubMedPubMedCentral Bus SA, Waaijman R, Arts M, de Haart M, Busch-Westbroek T, van Baal J, et al. Effect of custom-made footwear on foot ulcer recurrence in diabetes: a multicenter randomized controlled trial. Diabetes Care. 2013;36(12):4109–16.CrossRefPubMedPubMedCentral
26.
go back to reference Ulbrecht JS, Hurley T, Mauger DT, Cavanagh PR. Prevention of recurrent foot ulcers with plantar-pressure based in-shoe orthoses: The CareFUL prevention multicenter randomized controlled trial. Diabetes Care. 2014;37(7):1982–9.CrossRefPubMedPubMedCentral Ulbrecht JS, Hurley T, Mauger DT, Cavanagh PR. Prevention of recurrent foot ulcers with plantar-pressure based in-shoe orthoses: The CareFUL prevention multicenter randomized controlled trial. Diabetes Care. 2014;37(7):1982–9.CrossRefPubMedPubMedCentral
27.
go back to reference Bus SA, Valk GD, van Deursen RW, Armstrong DG, Caravaggi C, Hlaváček P, et al. The effectiveness of footwear and offloading interventions to prevent and heal foot ulcers and reduce plantar pressure in diabetes: a systematic review. Diabetes Metab Res Rev. 2008;24:S162–80.CrossRefPubMed Bus SA, Valk GD, van Deursen RW, Armstrong DG, Caravaggi C, Hlaváček P, et al. The effectiveness of footwear and offloading interventions to prevent and heal foot ulcers and reduce plantar pressure in diabetes: a systematic review. Diabetes Metab Res Rev. 2008;24:S162–80.CrossRefPubMed
28.
go back to reference Lewis J, Lipp A. Pressure-relieving interventions for treating diabetic foot ulcers. Cochrane Database Syst Rev. 2013:CD002302. Lewis J, Lipp A. Pressure-relieving interventions for treating diabetic foot ulcers. Cochrane Database Syst Rev. 2013:CD002302.
32.
go back to reference Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52:377–84.CrossRefPubMedPubMedCentral Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52:377–84.CrossRefPubMedPubMedCentral
34.
go back to reference Blackwell B, Aldridge R, Jacob S. A comparison of plantar pressure in patients with diabetic foot ulcers using different hosiery. Int J Low Extrem Wounds. 2002;1:174–8.CrossRefPubMed Blackwell B, Aldridge R, Jacob S. A comparison of plantar pressure in patients with diabetic foot ulcers using different hosiery. Int J Low Extrem Wounds. 2002;1:174–8.CrossRefPubMed
35.
go back to reference Veves A, Masson E, Fernando D, Boulton A. Use of experimental padded hosiery to reduce abnormal foot pressures in diabetic neuropathy. Diabetes Care. 1989;12:653–5.CrossRefPubMed Veves A, Masson E, Fernando D, Boulton A. Use of experimental padded hosiery to reduce abnormal foot pressures in diabetic neuropathy. Diabetes Care. 1989;12:653–5.CrossRefPubMed
36.
go back to reference Veves AME, Fernando DJ, Boulton AJ. Studies of experimental hosiery in diabetic neuropathic patients with high foot pressures. Diabet Med. 1990;7:324–6.CrossRefPubMed Veves AME, Fernando DJ, Boulton AJ. Studies of experimental hosiery in diabetic neuropathic patients with high foot pressures. Diabet Med. 1990;7:324–6.CrossRefPubMed
37.
go back to reference Garrow A, van Schie CH, Boulton AE. Reducing in-shoe plantar foot pressure in high-risk patients with diabetes. Diabetes Care. 2005;28:2001–6.CrossRefPubMed Garrow A, van Schie CH, Boulton AE. Reducing in-shoe plantar foot pressure in high-risk patients with diabetes. Diabetes Care. 2005;28:2001–6.CrossRefPubMed
38.
go back to reference Murray HJ, Veves A, Young MJ, Richie DH, Boulton AJ. Role of experimental socks in the care of high-risk diabetic foot. Diabetes Care. 1993;16:1190–3.CrossRefPubMed Murray HJ, Veves A, Young MJ, Richie DH, Boulton AJ. Role of experimental socks in the care of high-risk diabetic foot. Diabetes Care. 1993;16:1190–3.CrossRefPubMed
39.
go back to reference Banchellini E, Maccharini S, Valentia D, Loredana R, Tedeschi A, Alessia S, et al. Use of nanotechnology-designed foot sock in the management of pre-ulcerative conditions in the diabetic foot: results of a single blind randomized study. Int J Low Extrem Wounds. 2008;7(2):82–7.CrossRefPubMed Banchellini E, Maccharini S, Valentia D, Loredana R, Tedeschi A, Alessia S, et al. Use of nanotechnology-designed foot sock in the management of pre-ulcerative conditions in the diabetic foot: results of a single blind randomized study. Int J Low Extrem Wounds. 2008;7(2):82–7.CrossRefPubMed
40.
go back to reference Yick KL, Cheung NC, Leung KY, Ng SP, Yip J, Lo WT, et al. Effects of different types of socks on plantar pressures, in-shoe temperature and humidity in diabetic patients. J Donghua Univ. 2013;30(5):397–400. Yick KL, Cheung NC, Leung KY, Ng SP, Yip J, Lo WT, et al. Effects of different types of socks on plantar pressures, in-shoe temperature and humidity in diabetic patients. J Donghua Univ. 2013;30(5):397–400.
41.
go back to reference Herring KM, Richie DH. Friction blisters and sock fiber composition: a double blind study. J Am Podiatr Med Assoc. 1990;80(2):63–7.CrossRefPubMed Herring KM, Richie DH. Friction blisters and sock fiber composition: a double blind study. J Am Podiatr Med Assoc. 1990;80(2):63–7.CrossRefPubMed
42.
go back to reference Veves A, Hay EM, Boulton AJM. The use of specially padded hosiery in the painful rheumatoid foot. Foot (Edinb). 1992;1(4):175–7.CrossRef Veves A, Hay EM, Boulton AJM. The use of specially padded hosiery in the painful rheumatoid foot. Foot (Edinb). 1992;1(4):175–7.CrossRef
43.
go back to reference Herring KM, Richie DH. Comparison of cotton and acrylic socks using a generic cushion sole design for runners. J Am Podiatr Med Assoc. 1993;83(9):515–22.CrossRefPubMed Herring KM, Richie DH. Comparison of cotton and acrylic socks using a generic cushion sole design for runners. J Am Podiatr Med Assoc. 1993;83(9):515–22.CrossRefPubMed
44.
go back to reference Flot S, Hill V, Yamada W, McPoil TG, Cornwall MW. The effect of padded hosiery in reducing forefoot plantar pressures. Low Extrem. 1995;2(3):201–5. Flot S, Hill V, Yamada W, McPoil TG, Cornwall MW. The effect of padded hosiery in reducing forefoot plantar pressures. Low Extrem. 1995;2(3):201–5.
45.
go back to reference Blackmore T, Ball N, Scurr J. The effect of socks on vertical and anteroposterior ground reaction forces in walking and running. Foot (Edinb). 2011;21(1):1–5.CrossRef Blackmore T, Ball N, Scurr J. The effect of socks on vertical and anteroposterior ground reaction forces in walking and running. Foot (Edinb). 2011;21(1):1–5.CrossRef
46.
go back to reference Boutron I, Moher D, Altman DG, Schulz KF, Ravaud P. Extending the CONSORT Statement to Randomized Trials of Non-pharmacologic Treatment: Explanation and Elaboration. Ann Intern Med. 2008;148:295–309.CrossRefPubMed Boutron I, Moher D, Altman DG, Schulz KF, Ravaud P. Extending the CONSORT Statement to Randomized Trials of Non-pharmacologic Treatment: Explanation and Elaboration. Ann Intern Med. 2008;148:295–309.CrossRefPubMed
47.
go back to reference Cook A, Douet L, Boutron I. Descriptions of non-pharmacological interventions in clinical trials. Br Med J. 2013;347:f5212.CrossRef Cook A, Douet L, Boutron I. Descriptions of non-pharmacological interventions in clinical trials. Br Med J. 2013;347:f5212.CrossRef
48.
go back to reference Hro´bjartsson A, Thomsen ASS, Emanuelsson F, Tendal B, Rasmussen JV, Hilden J, et al. Observer bias in randomized clinical trials with time-to-event outcomes: systematic review of trials with both blinded and non-blinded outcome assessors. Int J Epidemiol. 2014;43(3):937–48.CrossRef Hro´bjartsson A, Thomsen ASS, Emanuelsson F, Tendal B, Rasmussen JV, Hilden J, et al. Observer bias in randomized clinical trials with time-to-event outcomes: systematic review of trials with both blinded and non-blinded outcome assessors. Int J Epidemiol. 2014;43(3):937–48.CrossRef
49.
go back to reference Young MJ, Cavanagh PR, Thomas G, Johnson MM, Murray H, Boulton AJ. The effect of callus removal on dynamic plantar foot pressures in diabetic patients. Diabet Med. 1992;9(1):55–7.CrossRefPubMed Young MJ, Cavanagh PR, Thomas G, Johnson MM, Murray H, Boulton AJ. The effect of callus removal on dynamic plantar foot pressures in diabetic patients. Diabet Med. 1992;9(1):55–7.CrossRefPubMed
50.
go back to reference Cowley MS, Boyko EJ, Shofer JB, Ahroni JH, Ledoux WR. Foot ulcer risk and location in relation to prospective clinical assessment of foot shape and mobility among persons with diabetes. Diabetes Res Clin Pract. 2008;82:226–32.CrossRefPubMed Cowley MS, Boyko EJ, Shofer JB, Ahroni JH, Ledoux WR. Foot ulcer risk and location in relation to prospective clinical assessment of foot shape and mobility among persons with diabetes. Diabetes Res Clin Pract. 2008;82:226–32.CrossRefPubMed
51.
go back to reference Armstrong DG, Peters EJ, Athanasiou KA, Lavery LA. Is there a critical level of plantar foot pressure to identify patients at risk for neuropathic foot ulceration? J Foot Ankle Surg. 1998;37(4):303–7.CrossRefPubMed Armstrong DG, Peters EJ, Athanasiou KA, Lavery LA. Is there a critical level of plantar foot pressure to identify patients at risk for neuropathic foot ulceration? J Foot Ankle Surg. 1998;37(4):303–7.CrossRefPubMed
52.
go back to reference Lavery LA, Armstrong DG, Wunderlich RP, Tredwell J, Boulton AJ. Predictive value of foot pressure assessment as part of a population-based diabetes disease management program. Diabetes Care. 2003;26(4):1069–73.CrossRefPubMed Lavery LA, Armstrong DG, Wunderlich RP, Tredwell J, Boulton AJ. Predictive value of foot pressure assessment as part of a population-based diabetes disease management program. Diabetes Care. 2003;26(4):1069–73.CrossRefPubMed
53.
go back to reference Barnett, SJ. International protocol guidelines for plantar pressure measurement. Diabetic Foot J. 1:137-140. Barnett, SJ. International protocol guidelines for plantar pressure measurement. Diabetic Foot J. 1:137-140.
54.
go back to reference Donaghue VM, Sarnow MR, Giurini JM, Chrzan JS, Habershaw GM, Veves A. Longitudinal in-shoe foot pressure relief achieved by specially designed footwear in high risk diabetic patients. Diabetes Res Clin Pract. 1996;31:109–14.CrossRefPubMed Donaghue VM, Sarnow MR, Giurini JM, Chrzan JS, Habershaw GM, Veves A. Longitudinal in-shoe foot pressure relief achieved by specially designed footwear in high risk diabetic patients. Diabetes Res Clin Pract. 1996;31:109–14.CrossRefPubMed
55.
go back to reference Mueller MJ, Hastings M, Commean PK, Smith KE, Pilgram TK, Robertson D, et al. Forefoot structural predictors of plantar pressures during walking in people with diabetes and peripheral neuropathy. J Biomech. 2003;36(7):1009–17.CrossRefPubMed Mueller MJ, Hastings M, Commean PK, Smith KE, Pilgram TK, Robertson D, et al. Forefoot structural predictors of plantar pressures during walking in people with diabetes and peripheral neuropathy. J Biomech. 2003;36(7):1009–17.CrossRefPubMed
56.
go back to reference Klaesner JW, Hastings MK, Zou D, Lewis C, Mueller MJ. Plantar tissue stiffness in patients with diabetes mellitus and peripheral neuropathy. Arch Phys Med Rehab. 2002;83(12):1796–801.CrossRef Klaesner JW, Hastings MK, Zou D, Lewis C, Mueller MJ. Plantar tissue stiffness in patients with diabetes mellitus and peripheral neuropathy. Arch Phys Med Rehab. 2002;83(12):1796–801.CrossRef
57.
go back to reference Huijberts MS, Schaper NC, Schalkwijk CG. Advanced glycation end products and diabetic foot disease. Diabetes Metab Res Rev. 2008;24 Suppl 1:S19–24.CrossRefPubMed Huijberts MS, Schaper NC, Schalkwijk CG. Advanced glycation end products and diabetic foot disease. Diabetes Metab Res Rev. 2008;24 Suppl 1:S19–24.CrossRefPubMed
58.
go back to reference Bertaux E, Derler S, Rossi RM, Zeng X, Koehl L, Ventenat V. Textile, Physiological, and Sensorial Parameters in Sock Comfort. Text Res J. 2010;80(17):1803–10.CrossRef Bertaux E, Derler S, Rossi RM, Zeng X, Koehl L, Ventenat V. Textile, Physiological, and Sensorial Parameters in Sock Comfort. Text Res J. 2010;80(17):1803–10.CrossRef
59.
go back to reference Dai XQ, Li Y, Zhang M, Cheung JTM. Effect of sock on biomechanical responses of foot during walking. Clin Biomech (Bristol, Avon). 2006;21:314–21.CrossRef Dai XQ, Li Y, Zhang M, Cheung JTM. Effect of sock on biomechanical responses of foot during walking. Clin Biomech (Bristol, Avon). 2006;21:314–21.CrossRef
60.
go back to reference Aluigi L. The Difoprev system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis. J Vasc Diag. 2014;2:15–21.CrossRef Aluigi L. The Difoprev system in treatment of the skin of the elderly: preliminary data obtained in patients with dryness and hyperkeratosis. J Vasc Diag. 2014;2:15–21.CrossRef
Metagegevens
Titel
Protective socks for people with diabetes: a systematic review and narrative analysis
Auteurs
Simon J Otter
Keith Rome
Belinda Ihaka
Andrew South
Mandy Smith
Amit Gupta
Frances Joseph
Peter Heslop
Publicatiedatum
01-12-2015
Uitgeverij
BioMed Central
Gepubliceerd in
Journal of Foot and Ankle Research / Uitgave 1/2015
Elektronisch ISSN: 1757-1146
DOI
https://doi.org/10.1186/s13047-015-0068-7

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