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Quality of Life Research
Gepubliceerd in: Quality of Life Research 7/2017

03-03-2017

Prospective associations of exercise and depressive symptoms in older adults: the role of apolipoprotein E4

Auteurs: Po-Wen Ku, Andrew Steptoe, Li-Jung Chen

Gepubliceerd in: Quality of Life Research | Uitgave 7/2017

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Abstract

Purpose

Exercise is associated with reduced risk of depressive symptoms at older ages, while recent work suggests that the apolipoprotein E type 4 allele (APOE-e4) may increase risk. There are no studies of whether APOE-e4 moderates the relationship between exercise and later life depressive symptoms. This study aimed to explore whether the prospective associations between exercise and subsequent depressive symptoms were distinct between APOE-e4 carriers and non-carriers using nationwide data.

Methods

Data from 639 participants (mean age = 66.14, SD = 7.26) in 2000 with 6 years of follow-up were studied. Depressive symptoms were assessed using the Center for Epidemiologic Studies–Depression Scale. Exercise and the APOE genotype were also assessed at baseline. Negative binomial regression models were conducted to examine the combined effects of exercise and APOE-e4 status on subsequent depressive symptoms when controlling for baseline depressive symptoms and other covariates. Sensitivity analyses to test for confounding, reverse causality, and attrition were conducted.

Results

Among APOE-e4 carriers, there was no significant difference in depressive symptoms between high active and low active groups. In contrast, high active APOE-e4 non-carriers had fewer depressive symptoms than low active APOE-e4 non-carriers. The beneficial effect of exercise on depressive symptoms is restricted to APOE-e4 non-carriers. Sensitivity analyses provided further support for the robustness of these findings.

Conclusions

This is the first prospective study investigating whether APOE-e4 moderates the association between exercise and depressive symptoms. It proposes that genetic variation in APOE may influence the effect of exercise on depressive symptoms.
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Literatuur
1.
Ferrari, A. J., Charlson, F. J., Norman, R. E., Patten, S. B., Freedman, G., Murray, C. J. L., Vos, T., & Whiteford, H. A. (2013). Burden of depressive disorders by country, sex, age, and year: Findings from the Global Burden of Disease Study 2010. PLoS Medicine, 10(11), e1001547.PubMedPubMedCentralCrossRef
2.
World Health Organization (2008). The global burden of disease: 2004 update. Geneva: World Health Organization.
3.
4.
Blazer, D. G. (2003). Depression in late life: review and commentary. Journals of Gerontology Series A, 58(3), M249–M265.CrossRef
5.
Chapman, D. P., & Perry, G. S. (2008). Peer reviewed: Depression as a major component of public health for older adults. Preventing Chronic Disease, 5(1), 1–9.
6.
Depp, C. A., & Jeste, D. V. (2006). Definitions and predictors of successful aging: A comprehensive review of larger quantitative studies. American Journal of Geriatric Psychiatry, 14(1), 6–20.PubMedCrossRef
7.
Dogra, S., & Stathokostas, L. (2012). Sedentary behavior and physical activity are independent predictors of successful aging in middle-aged and older adults. Journal of Aging Rresearch, 2012, 190654.
8.
UK Department of Health. (2011). Start active, stay active: A report on physical activity from the four home countries’ Chief Medical Officers. London: Department of Health.
9.
US Department of Health and Human Services. (2008). 2008 Physical activity guidelines for Americans. Washington, DC: US Department of Health and Human Services.
10.
Nelson, M., Rejeski, W., Blair, S., Duncan, P., Judge, J., King, A., Macera, C., & Castaneda-Sceppa, C. (2007). Physical activity and public health in older adults: Recommendation from the American College of Sports Medicine and the American Heart Association. Medicine & Science in Sports & Exercise, 39, 1435–1445.CrossRef
11.
Mammen, G., & Faulkner, G. (2013). Physical activity and the prevention of depression: A systematic review of prospective studies. American Journal of Preventive Medicine, 45(5), 649–657.PubMedCrossRef
12.
Bridle, C., Spanjers, K., Patel, S., Atherton, N. M., & Lamb, S. E. (2012). Effect of exercise on depression severity in older people: Systematic review and meta-analysis of randomised controlled trials. British Journal of Psychiatry, 201(3), 180–185.PubMedCrossRef
13.
Schuch, F. B., Vancampfort, D., Rosenbaum, S., Richards, J., Ward, P. B., Veronese, N., Solmi, M., Cadore, E. L., & Stubbs, B. (2016). Exercise for depression in older adults: A meta-analysis of randomized controlled trials adjusting for publication bias. Revista Brasileira de Psiquiatria, 38(3), 247–254.PubMedCrossRef
14.
Murri, M. B., Amore, M., Menchetti, M., Toni, G., Neviani, F., Cerri, M., Rocchi, M., Zocchi, D., Bagnoli, L., & Tam, E. (2015). Physical exercise for late-life major depression. British Journal of Psychiatry, 207(3), 235–242.CrossRef
15.
da Silva, J., Gonçalves-Pereira, M., Xavier, M., & Mukaetova-Ladinska, E. B. (2013). Affective disorders and risk of developing dementia: Systematic review. British Journal of Psychiatry, 202(3), 177–186.PubMedCrossRef
16.
Beydoun, M. A., Beydoun, H. A., Gamaldo, A. A., Teel, A., Zonderman, A. B., & Wang, Y. (2014). Epidemiologic studies of modifiable factors associated with cognition and dementia: Systematic review and meta-analysis. BMC Public Health, 14(1), 1–33.CrossRef
17.
Raichlen, D. A., & Alexander, G. E. (2014). Exercise, APOE genotype, and the evolution of the human lifespan. Trends in Neurosciences, 37(5), 247–255.PubMedPubMedCentralCrossRef
18.
Low, L.-F., Yap, M. H. W., & Brodaty, H. (2010). Will testing for apolipoprotein E assist in tailoring dementia risk reduction? A review. Neuroscience & Biobehavioral Reviews, 34(3), 408–437.CrossRef
19.
20.
Skoog, I., Waern, M., Duberstein, P., Blennow, K., Zetterberg, H., Börjesson-Hanson, A., Östling, S., Guo, X., Kern, J., & Gustafson, D. (2015). A 9-year prospective population-based study on the association between the APOE* E4 allele and late-life depression in Sweden. Biological Psychiatry, 78(10), 730–736.PubMedCrossRef
21.
Cornman, J. C., Glei, D. A., Goldman, N., Chang, M.-C., Lin, H.-S., Chuang, Y.-L., Hurng, B.-S., Lin, Y.-H., Lin, S.-H., Liu, I.-W., Liu, H.-Y., & Weinstein, M. (2016). Cohort profile: the social environment and biomarkers of aging study (SEBAS) in Taiwan. International Journal of Epidemiology, 45(1), 54–63.PubMedCrossRef
22.
Lee, K. L., Ou, Y. L., Chen, S. H., & Weng, L. J. (2009). The psychometric properties of a short form of the CES-D used in the Taiwan longitudinal study on aging. Formosa Journal of Mental Health, 22(4), 389–410.
23.
Krause, N., & Liang, J. (1992). Cross-cultural variations in depressive symptoms in later life. International Psychogeriatrics, 4(4), 185–202.PubMed
24.
Ofstedal, M. B., Zimmer, Z. S., & Lin, H. S. (1999). A comparison of correlates of cognitive functioning in older persons in Taiwan and the United States. Journals of Gerontology Series B, 54B(5), S291–S301.CrossRef
25.
Seplaki, C. L., Goldman, N., Weinstein, M., & Lin, Y.-H. (2006). Before and after the 1999 Chi-Chi earthquake: Traumatic events and depressive symptoms in an older population. Social Science and Medicine, 62(12), 3121–3132.PubMedCrossRef
26.
Ku, P. W., Fox, K. R., Chen, L. J., & Chou, P. (2012). Physical activity and depressive symptoms in older adults: 11-year follow-up. American Journal of Preventive Medicine, 42(4), 355–362.PubMedCrossRef
27.
Hagiwara, A., Ito, N., Sawai, K., & Kazuma, K. (2008). Validity and reliability of the physical activity scale for the elderly (PASE) in Japanese elderly people. Geriatrics & Gerontology International, 8(3), 143–151.CrossRef
28.
Harada, N. D., Chiu, V., King, A. C., & Stewart, A. L. (2001). An evaluation of three self-report physical activity instruments for older adults. Medicine & Science in Sports & Exercise, 33(6), 962.CrossRef
29.
Ku, P. W., Fox, K. R., & Chen, L. J. (2009). Physical activity and depressive symptoms in Taiwanese older adults: A seven-year follow-up study. Preventive Medicine, 48(3), 250–255.PubMedCrossRef
30.
Hu, W., & Lu, J. (2015). Associations of chronic conditions, APOE4 allele, stress factors, and health behaviors with self-rated health. BMC Geriatrics, 15(1), 1–8.CrossRef
31.
Taiwan Department of Health (2003). Identification, evaluation, and treatment of overweight and obesity in adults in Taiwan. Taipei: Taiwan Department of Health.
32.
Scarmeas, N., Luchsinger, J. A., Schupf, N., Brickman, A. M., Cosentino, S., Tang, M. X., & Stern, Y. (2009). Physical activity, diet, and risk of Alzheimer disease. JAMA, 302(6), 627–637.PubMedPubMedCentralCrossRef
33.
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987). A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. Journal of chronic diseases, 40(5), 373–383.PubMedCrossRef
34.
Pfeiffer, E. (1975). A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. Journal of the American Geriatrics Society, 23, 433–441.PubMedCrossRef
35.
World Health Organization (2010). Global recommendations on physical activity for health. Geneva: World Health Organization.
36.
Allison, P. (2012). Logistic regression using SAS: Theory and application (2nd edn.). Cary, NC: SAS Institute Inc.
37.
Erkinjuntti, T., Sulkava, R., Wikström, J., & Autio, L. (1987). Short portable mental status questionnaire as a screening test for dementia and delirium among the elderly. Journal of the American Geriatrics Society, 35(5), 412–416.PubMedCrossRef
38.
Schuch, F. B., Deslandes, A. C., Stubbs, B., Gosmann, N. P., da Silva, C. T. B., & de Almeida Fleck, M. P.(2016). Neurobiological effects of exercise on major depressive disorder: A systematic review. Neuroscience & Biobehavioral Reviews, 61, 1–11.CrossRef
39.
Olesen, P. J., Gustafson, D. R., Simoni, M., Pantoni, L., Ostling, S., Guo, X., & Skoog, I. (2010). Temporal lobe atrophy and white matter lesions are related to major depression over 5 years in the elderly. Neuropsychopharmacology, 35(13), 2638–2645.PubMedPubMedCentralCrossRef
40.
Jofre-Monseny, L., Minihane, A. M., & Rimbach, G. (2008). Impact of apoE genotype on oxidative stress, inflammation and disease risk. Molecular Nutrition & Food Research, 52(1), 131–145.CrossRef
41.
42.
Olivieri, O., Martinelli, N., Bassi, A., Trabetti, E., Girelli, D., Pizzolo, F., Friso, S., Pignatti, P. F., & Corrocher, R. (2007). ApoE ε2/ε3/ε4 polymorphism, ApoC-III/ApoE ratio and metabolic syndrome. Clinical and Experimental Medicine, 7(4), 164–172.PubMedCrossRef
43.
Vancampfort, D., Stubbs, B., Mitchell, A. J., De Hert, M., Wampers, M., Ward, P. B., Rosenbaum, S., & Correll, C. U. (2015). Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: A systematic review and meta-analysis. World Psychiatry, 14(3), 339–347.PubMedPubMedCentralCrossRef
44.
Vancampfort, D., Correll, C. U., Galling, B., Probst, M., De Hert, M., Ward, P. B., Rosenbaum, S., Gaughran, F., Lally, J., & Stubbs, B. (2016). Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: A systematic review and large scale meta-analysis. World Psychiatry, 15(2), 166–174.PubMedPubMedCentralCrossRef
45.
Brommelhoff, J. A., Gatz, M., Johansson, B., McArdle, J. J., Fratiglioni, L., & Pedersen, N. L. (2009). Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins. Psychology and Aging, 24(2), 373–384.PubMedPubMedCentralCrossRef
Metagegevens
Titel
Prospective associations of exercise and depressive symptoms in older adults: the role of apolipoprotein E4
Auteurs
Po-Wen Ku
Andrew Steptoe
Li-Jung Chen
Publicatiedatum
03-03-2017
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 7/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-017-1537-1

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