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Gepubliceerd in:

08-04-2021

Prospective analysis of disability and quality of life in patients with chronic inflammatory demyelinating polyradiculoneuropathy

Auteurs: Ivo Bozovic, Marina Peric, Ana Arsic Azanjac, Aleksa Palibrk, Ivana Bulatovic, Dejan Aleksic, Stojan Peric, Ivana Basta

Gepubliceerd in: Quality of Life Research | Uitgave 9/2021

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Abstract

Purpose

Even treated chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) continues to pose a significant burden in patients’ everyday functioning and may continuously affect their quality of life (QoL). The aims of our prospective study were to analyze health-related QoL in CIDP patients during a 1-year follow-up period in real-life settings and to compare QoL changes with changes in disability and with patient impression of change.

Methods

The study comprised 59 patients diagnosed with CIDP. SF-36 questionnaire was applied in order to evaluate patients’ QoL. Inflammatory neuropathy cause and treatment (INCAT) disability scale was used to assess patients’ functionality. The second question from the SF-36 questionnaire was used as an estimation of the patient impression of change (PIC) after 1 year.

Results

SF-36 scores did not change over time in the group as a whole. According to INCAT disability scores, worsening was registered in 24 (40%) patients and improvement in 8 (14%). Fifteen (25%) patients reported worsening and the same number reported improvement, according to PIC. Concordant results on INCAT and PIC were registered in 49% of patients. Pooled SF-36 scores moderately correlated with pooled INCAT disability scores (rho = − 0.27 to − 0.59, p < 0.01). One-year changes of SF-36 scores did not differ when compared to different INCAT outcomes (worsening, stable, improvement). On the other hand, significant changes of SF-36 scores in different outcome groups according to PIC (worsening, stable, improvement) were noted (p < 0.01).

Conclusion

INCAT, PIC, and SF-36 are complementary outcome measures that provide neurologists with useful items of information. We propose complementary use of these scales in CIDP patients in everyday clinical practice in order to detect worsening of the disease and/or of related symptoms on time.
Literatuur
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Metagegevens
Titel
Prospective analysis of disability and quality of life in patients with chronic inflammatory demyelinating polyradiculoneuropathy
Auteurs
Ivo Bozovic
Marina Peric
Ana Arsic Azanjac
Aleksa Palibrk
Ivana Bulatovic
Dejan Aleksic
Stojan Peric
Ivana Basta
Publicatiedatum
08-04-2021
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 9/2021
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-021-02838-w