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23-09-2022 | Empirical Research

Prolonged Rather Than Early Childhood Parent–Child Separation Predicts Change in Molecular Markers of Cellular Aging: A Consideration of the Role of Adolescence

Auteurs: Shihong Wang, Xudong Zhao, Yue Yu, Fangbiao Tao, Deyun Liu, Ying Sun

Gepubliceerd in: Journal of Youth and Adolescence | Uitgave 1/2023

Abstract

Early life adversity is a major risk factor for the onset of psychopathology, and cellular aging may be a mechanism underlying these associations. It is unknown whether and how the pattern (timing and duration) of parent-child separation is associated with accelerated cellular aging, particularly with respect to functional aging and replicative senescence, indexed by mitochondrial DNA copy number (mtDNAcn) elevation and telomere length (TL) attrition. This cohort study included 252 rural adolescents (mean age 11.62 years, SD: 1.56). Nearly one in five participants were persistently separated from both parents since birth. Compared with participants who never separated from their parents, adolescents with prolonged parent-child separation had higher acceleration both in functional aging and replicative senescence of cells. However, that was not the case in adolescents who experienced parent-child separation in early childhood but regained stable parental care during adolescence. These findings indicate that pubertal development reopens a window of opportunity for buffering the adverse biological effect based on significant improvements in the supportiveness of the caregiving environment relative to that in childhood. Translating such knowledge to inform intervention and prevention strategies for youths exposed to adversity is a critical goal for the field.

vorige artikel Sexual Orientation and Gender Identity Change Efforts for Young People in New Zealand: Demographics, Types of Suggesters, and Associations with Mental Health

volgende artikel Capturing Hassles and Uplifts in Adolescents’ Daily Lives: Links with Physical and Mental Well-Being

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Titel: Prolonged Rather Than Early Childhood Parent–Child Separation Predicts Change in Molecular Markers of Cellular Aging: A Consideration of the Role of Adolescence
Auteurs: Shihong Wang
Xudong Zhao
Yue Yu
Fangbiao Tao
Deyun Liu
Ying Sun
Publicatiedatum: 23-09-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Youth and Adolescence / Uitgave 1/2023
Print ISSN: 0047-2891
Elektronisch ISSN: 1573-6601
DOI: https://doi.org/10.1007/s10964-022-01681-7

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