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23-09-2022 | Empirical Research

Prolonged Rather Than Early Childhood Parent–Child Separation Predicts Change in Molecular Markers of Cellular Aging: A Consideration of the Role of Adolescence

Auteurs: Shihong Wang, Xudong Zhao, Yue Yu, Fangbiao Tao, Deyun Liu, Ying Sun

Gepubliceerd in: Journal of Youth and Adolescence | Uitgave 1/2023

Abstract

Early life adversity is a major risk factor for the onset of psychopathology, and cellular aging may be a mechanism underlying these associations. It is unknown whether and how the pattern (timing and duration) of parent-child separation is associated with accelerated cellular aging, particularly with respect to functional aging and replicative senescence, indexed by mitochondrial DNA copy number (mtDNAcn) elevation and telomere length (TL) attrition. This cohort study included 252 rural adolescents (mean age 11.62 years, SD: 1.56). Nearly one in five participants were persistently separated from both parents since birth. Compared with participants who never separated from their parents, adolescents with prolonged parent-child separation had higher acceleration both in functional aging and replicative senescence of cells. However, that was not the case in adolescents who experienced parent-child separation in early childhood but regained stable parental care during adolescence. These findings indicate that pubertal development reopens a window of opportunity for buffering the adverse biological effect based on significant improvements in the supportiveness of the caregiving environment relative to that in childhood. Translating such knowledge to inform intervention and prevention strategies for youths exposed to adversity is a critical goal for the field.

vorige artikel Sexual Orientation and Gender Identity Change Efforts for Young People in New Zealand: Demographics, Types of Suggesters, and Associations with Mental Health

volgende artikel Capturing Hassles and Uplifts in Adolescents’ Daily Lives: Links with Physical and Mental Well-Being

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Belsky, J. (2019). Early-life adversity accelerates child and adolescent development. Current Directions in Psychological Science, 28, 241–246. https://doi.org/10.1177/0963721419837670. CrossRef

Bernadotte, A., Mikhelson, V. M., & Spivak, I. M. (2016). Markers of cellular senescence. Telomere shortening as a marker of cellular senescence. Aging, 8(1), 3–11. https://doi.org/10.18632/aging.100871. CrossRef

Birch, J., Barnes, P. J., & Passos, J. F. (2018). Mitochondria, telomeres and cell senescence: implications for lung ageing and disease. Pharmacology & Therapeutics, 183, 34–49. https://doi.org/10.1016/j.pharmthera.2017.10.005. CrossRef

Cai, N., Chang, S., Li, Y., Li, Q., Hu, J., Liang, J., Song, L., Kretzschmar, W., Gan, X., Nicod, J., Rivera, M., Deng, H., Du, B., Li, K., Sang, W., Gao, J., Gao, S., Ha, B., Ho, H. Y., Hu, C., & Flint, J. (2015). Molecular signatures of major depression. Current Biology: CB, 25(9), 1146–1156. https://doi.org/10.1016/j.cub.2015.03.008. CrossRef

Campisi, J., & Robert, L. (2014). Cell senescence: role in aging and age-related diseases. Interdisciplinary Topics in Gerontology, 39, 45–61. https://doi.org/10.1159/000358899. CrossRef

Chen, X., Zeng, C., Gong, C., Zhang, L., Wan, Y., Tao, F., & Sun, Y. (2019). Associations between early life parent-child separation and shortened telomere length and psychopathological outcomes during adolescence. Psychoneuroendocrinology, 103, 195–202. https://doi.org/10.1016/j.psyneuen.2019.01.021. CrossRef

De Gaetano, A., Solodka, K., Zanini, G., Selleri, V., Mattioli, A. V., Nasi, M., & Pinti, M. (2021). Molecular mechanisms of mtDNA-mediated inflammation. Cells, 10(11), 2898. https://doi.org/10.3390/cells10112898. CrossRef

Drury, S. S., Theall, K., Gleason, M. M., Smyke, A. T., De Vivo, I., Wong, J. Y., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2012). Telomere length and early severe social deprivation: linking early adversity and cellular aging. Molecular Psychiatry, 17(7), 719–727. https://doi.org/10.1038/mp.2011.53. CrossRef

Dunn, E. C., Soare, T. W., Raffeld, M. R., Busso, D. S., Crawford, K. M., Davis, K. A., Fisher, V. A., Slopen, N., Smith, A., Tiemeier, H., & Susser, E. S. (2018). What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: recency, accumulation, or sensitive periods. Psychological Medicine, 48(15), 2562–2572. https://doi.org/10.1017/S0033291718000181. CrossRef

Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004). Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences of the United States of America, 101(49), 17312–17315. https://doi.org/10.1073/pnas.0407162101. CrossRef

Fellmeth, G., Rose-Clarke, K., Zhao, C., Busert, L. K., Zheng, Y., Massazza, A., Sonmez, H., Eder, B., Blewitt, A., Lertgrai, W., Orcutt, M., Ricci, K., Mohamed-Ahmed, O., Burns, R., Knipe, D., Hargreaves, S., Hesketh, T., Opondo, C., & Devakumar, D. (2018). Health impacts of parental migration on left-behind children and adolescents: a systematic review and meta-analysis. Lancet, 392(10164), 2567–2582. https://doi.org/10.1016/S0140-6736(18)32558-3. CrossRef

Ferrón, S. R., Marqués-Torrejón, M. A., Mira, H., Flores, I., Taylor, K., Blasco, M. A., & Fariñas, I. (2009). Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 29(46), 14394–14407. https://doi.org/10.1523/JNEUROSCI.3836-09.2009. CrossRef

Gabard-Durnam, L. J., & McLaughlin, K. A. (2019). Do sensitive periods exist for exposure to adversity? Biological Psychiatry, 85(10), 789–791. https://doi.org/10.1016/j.biopsych.2019.03.975. CrossRef

Gee, D. G. (2021). Early adversity and development: parsing heterogeneity and identifying pathways of risk and resilience. The American Journal of Psychiatry, 178(11), 998–1013. https://doi.org/10.1176/appi.ajp.2021.21090944. CrossRef

Gunnar, M. R., DePasquale, C. E., Reid, B. M., Donzella, B., & Miller, B. S. (2019). Pubertal stress recalibration reverses the effects of early life stress in postinstitutionalized children. Proceedings of the National Academy of Sciences of the United States of America, 116(48), 23984–23988. https://doi.org/10.1073/pnas.1909699116. CrossRef

Hanssen, L. M., Schutte, N. S., Malouff, J. M., & Epel, E. S. (2017). The relationship between childhood psychosocial stressor level and telomere length: a meta-analysis. Health Psychology Research, 5(1), 6378. https://doi.org/10.4081/hpr.2017.6378. CrossRef

Hautekiet, P., Nawrot, T. S., Janssen, B. G., Martens, D. S., De Clercq, E. M., Dadvand, P., Plusquin, M., Bijnens, E. M., & Saenen, N. D. (2021). Child buccal telomere length and mitochondrial DNA content as biomolecular markers of ageing in association with air pollution. Environment International, 147, 106332. https://doi.org/10.1016/j.envint.2020.106332. CrossRef

He, L., Li, X., Wang, W., Wang, Y., Qu, H., Zhao, Y., & Lin, D. (2021). Clustering of multiple lifestyle behaviors among migrant, left-behind and local adolescents in China: a cross-sectional study. BMC Public Health, 21(1), 542. https://doi.org/10.1186/s12889-021-10584-4. CrossRef

Howland, M. A., Donzella, B., Miller, B. S., & Gunnar, M. R. (2020). Pubertal recalibration of cortisol-DHEA coupling in previously-institutionalized children. Hormones and Behavior, 125, 104816. CrossRef

Humphreys, K. L., Esteves, K., Zeanah, C. H., Fox, N. A., Nelson, 3rd, C. A., & Drury, S. S. (2016). Accelerated telomere shortening: tracking the lasting impact of early institutional care at the cellular level. Psychiatry Res., 246, 95–100. https://doi.org/10.1016/j.psychres.2016.09.023. CrossRef

Humphreys, K. L., Sisk, L. M., Manczak, E. M., Lin, J., & Gotlib, I. H. (2020). Depressive symptoms predict change in telomere length and mitochondrial DNA copy number across adolescence. Journal of the American Academy of Child Adolescent Psychiatry, 59(12), 1364–1370.e2. https://doi.org/10.1016/j.jaac.2019.09.031. CrossRef

James, S., McLanahan, S., Brooks-Gunn, J., Mitchell, C., Schneper, L., Wagner, B., & Notterman, D. A. (2017). Sleep duration and telomere length in children. The Journal of Pediatrics, 187, 247–252.e1. https://doi.org/10.1016/j.jpeds.2017.05.014. CrossRef

Jiang, Y., Da, W., Qiao, S., Zhang, Q., Li, X., Ivey, G., & Zilioli, S. (2019). Basal cortisol, cortisol reactivity, and telomere length: a systematic review and meta-analysis. Psychoneuroendocrinology, 103, 163–172. https://doi.org/10.1016/j.psyneuen.2019.01.022. CrossRef

Lamprokostopoulou, A., Moschonis, G., Manios, Y., Critselis, E., Nicolaides, N. C., Stefa, A., Koniari, E., Gagos, S., & Charmandari, E. (2019). Childhood obesity and leucocyte telomere length. European Journal of Clinical Investigation, 49(12), e13178. https://doi.org/10.1111/eci.13178. CrossRef

Levy, J., Goldstein, A., & Feldman, R. (2019). The neural development of empathy is sensitive to caregiving and early trauma. Nature Communications, 10(1), 1905. https://doi.org/10.1038/s41467-019-09927-y. CrossRef

Lin, J., & Epel, E. (2022). Stress and telomere shortening: Insights from cellular mechanisms. Ageing Research Reviews, 73, 101507. https://doi.org/10.1016/j.arr.2021.101507. CrossRef

Mason, P. J., & Perdigones, N. (2013). Telomere biology and translational research. Translational Research, 162(6), 333–342. https://doi.org/10.1016/j.trsl.2013.08.009. CrossRef

Mathur, M. B., Epel, E., Kind, S., Desai, M., Parks, C. G., Sandler, D. P., & Khazeni, N. (2016). Perceived stress and telomere length: a systematic review, meta-analysis, and methodologic considerations for advancing the field. Brain, Behavior, and Immunity, 54, 158–169. https://doi.org/10.1016/j.bbi.2016.02.002. CrossRef

McDermott, C. L., Hilton, K., Park, A. T., Tooley, U. A., Boroshok, A. L., Mupparapu, M., Scott, J. M., Bumann, E. E., & Mackey, A. P. (2021). Early life stress is associated with earlier emergence of permanent molars. Proceedings of the National Academy of Sciences of the United States of America, 118(24), e2105304118 https://doi.org/10.1073/pnas.2105304118. CrossRef

Méndez Leal, A. S., & Silvers, J. A. (2021). Neurobiological Markers of Resilience to Early-Life Adversity During Adolescence. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(2), 238–247. https://doi.org/10.1016/j.bpsc.2020.08.004. CrossRef

Moody, H. R. (2010). Why do our bodies grow old? In: Wiley K. D. L., Westby J. (eds) Aging. Concepts and Controversies, 6th edn. Thousand Oaks, CA.

Navarro-Ibarra, M. J., Hernández, J., & Caire-Juvera, G. (2019). Diet, physical activity and telomere length in adults. Dieta, actividad física y longitud telomérica en adultos. Nutricion Hospitalaria, 36(6), 1403–1417. https://doi.org/10.20960/nh.02673. CrossRef

Nguyen, M. T., Saffery, R., Burgner, D., Lycett, K., Vryer, R., Grobler, A., Dwyer, T., Ranganathan, S., & Wake, M. (2019). Telomere length and lung function in a population-based cohort of children and mid-life adults. Pediatric Pulmonology, 54(12), 2044–2052. https://doi.org/10.1002/ppul.24489. CrossRef

Picard, M., & McEwen, B. S. (2018). Psychological Stress and Mitochondria: A Conceptual Framework. Psychosomatic Medicine, 80(2), 126–140. https://doi.org/10.1097/PSY.0000000000000544. CrossRef

Qu, G., Shu, L., Zhang, J., Wu, Y., Ma, S., Han, T., Zhang, H., Wang, J., & Sun, Y. (2021). Suicide ideation, suicide plan, and suicide attempt among left-behind children and adolescents: A systematic review and meta-analysis. Suicide and Life Threatening Behaviour, 51(3), 515–527. https://doi.org/10.1111/sltb.12731. CrossRef

Raffington, L., Belsky, D. W., Kothari, M., Malanchini, M., Tucker-Drob, E. M., & Harden, K. P. (2021). Socioeconomic Disadvantage and the Pace of Biological Aging in Children. Pediatrics, 147(6), e2020024406. CrossRef

Ridout, K. K., Coe, J. L., Parade, S. H., Marsit, C. J., Kao, H. T., Porton, B., Carpenter, L. L., Price, L. H., & Tyrka, A. R. (2020). Molecular markers of neuroendocrine function and mitochondrial biogenesis associated with early life stress. Psychoneuroendocrinology, 116, 104632. https://doi.org/10.1016/j.psyneuen.2020.104632. CrossRef

Romeo, R. D. (2018). The metamorphosis of adolescent hormonal stress reactivity: a focus on animal models. Frontiers in Neuroendocrinology, 49, 43–51. https://doi.org/10.1016/j.yfrne.2017.12.003. CrossRef

Sahin, E., & DePinho, R. A. (2012). Axis of ageing: telomeres, p53 and mitochondria. Nature Reviews. Molecular Cell Biology, 13(6), 397–404. https://doi.org/10.1038/nrm3352. CrossRef

Schriber, R. A., & Guyer, A. E. (2016). Adolescent neurobiological susceptibility to social context. Developmental Cognitive Neuroscience, 19, 1–18. CrossRef

Shaughnessy, D. T., McAllister, K., Worth, L., Haugen, A. C., Meyer, J. N., Domann, F. E., Van Houten, B., Mostoslavsky, R., Bultman, S. J., Baccarelli, A. A., Begley, T. J., Sobol, R. W., Hirschey, M. D., Ideker, T., Santos, J. H., Copeland, W. C., Tice, R. R., Balshaw, D. M., & Tyson, F. L. (2014). Mitochondria, energetics, epigenetics, and cellular responses to stress. Environmental Health Perspectives, 122(12), 1271–1278. https://doi.org/10.1289/ehp.1408418. CrossRef

Sheridan, M. A., & McLaughlin, K. A. (2014). Dimensions of early experience and neural development: deprivation and threat. Trends in Cognitive Sciences, 18(11), 580–585. https://doi.org/10.1016/j.tics.2014.09.001. CrossRef

Shi, H., Zhang, J., Du, Y., Zhao, C., Huang, X., & Wang, X. (2020). The association between parental migration and early childhood nutrition of left-behind children in rural China. BMC Public Health, 20(1), 246. https://doi.org/10.1186/s12889-020-8350-4. CrossRef

Sisk, C. L., & Romeo, R. D. (2019). Coming of age: the neurobiology and psychobiology of puberty and adolescence. Oxford University Press.

Sumner, J. A., Colich, N. L., Uddin, M., Armstrong, D., & McLaughlin, K. A. (2019). Early Experiences of Threat, but Not Deprivation, Are Associated With Accelerated Biological Aging in Children and Adolescents. Biological Psychiatry, 85(3), 268–278. https://doi.org/10.1016/j.biopsych.2018.09.008. CrossRef

Theurey, P., & Pizzo, P. (2018). The Aging Mitochondria. Genes, 9(1), 22. https://doi.org/10.3390/genes9010022. CrossRef

Vaiserman, A., & Krasnienkov, D. (2021). Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives. Frontiers in Genetics, 11, 630186. https://doi.org/10.3389/fgene.2020.630186. CrossRef

Van Der Stukken, C., Nawrot, T. S., Alfano, R., Wang, C., Langie, S., Plusquin, M., Janssen, B. G., & Martens, D. S. (2022). The telomere-mitochondrial axis of aging in newborns. Aging, 14(4), 1627–1650. https://doi.org/10.18632/aging.203897. CrossRef

Wade, M., Fox, N. A., Zeanah, C. H., Nelson, C. A., & Drury, S. S. (2020). Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project. Journal of the American Academy Child and Adolescent Psychiatry, 59(1), 140–148.e3. https://doi.org/10.1016/j.jaac.2019.02.013. CrossRef

Wolf, E. J., Maniates, H., Nugent, N., Maihofer, A. X., Armstrong, D., Ratanatharathorn, A., Ashley-Koch, A. E., Garrett, M., Kimbrel, N. A., Lori, A., Aiello, A. E., Baker, D. G., Beckham, J. C., Boks, M. P., Galea, S., Geuze, E., Hauser, M. A., Kessler, R. C., Koenen, K. C., & Logue, M. W., Va Mid-Atlantic Mirecc Workgroup. (2018). Traumatic stress and accelerated DNA methylation age: A meta-analysis. Psychoneuroendocrinology, 92, 123–134. https://doi.org/10.1016/j.psyneuen.2017.12.007. CrossRef

Woody, A., Hamilton, K., Livitz, I. E., Figueroa, W. S., & Zoccola, P. M. (2017). Buccal telomere length and its associations with cortisol, heart rate variability, heart rate, and blood pressure responses to an acute social evaluative stressor in college students. Stress (Amsterdam, Netherlands), 20(3), 249–257. https://doi.org/10.1080/10253890.2017.1328494. CrossRef

Zhang, D. D., Fang, J., Zhang, L., Yuan, J. Y., Wan, Y. H., Su, P. Y., Tao, F. B., & Sun, Y. (2021). Pubertal recalibration of cortisol reactivity following early life parent-child separation. Journal of Affective Disorders, 278, 320–326. https://doi.org/10.1016/j.jad.2020.09.030. CrossRef

Zhang, S., Li, R., Yang, Y., Chen, Y., Yang, S., Li, J., Wu, C., Kong, T., Liu, T., Cai, J., Fu, L., Zhao, Y., Hui, R., & Zhang, W. (2020). Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering. Aging and Disease, 11(3), 494–508. https://doi.org/10.14336/AD.2019.0721. CrossRef

Titel: Prolonged Rather Than Early Childhood Parent–Child Separation Predicts Change in Molecular Markers of Cellular Aging: A Consideration of the Role of Adolescence
Auteurs: Shihong Wang
Xudong Zhao
Yue Yu
Fangbiao Tao
Deyun Liu
Ying Sun
Publicatiedatum: 23-09-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Youth and Adolescence / Uitgave 1/2023
Print ISSN: 0047-2891
Elektronisch ISSN: 1573-6601
DOI: https://doi.org/10.1007/s10964-022-01681-7

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