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Gepubliceerd in: Quality of Life Research 4/2013

01-05-2013

Prognostic value of quality of life measured after treatment on subsequent survival in patients with nasopharyngeal carcinoma

Auteurs: Wen-Ling Tsai, Chih-Yen Chien, Hsuan-Ying Huang, Kuan-Cho Liao, Fu-Min Fang

Gepubliceerd in: Quality of Life Research | Uitgave 4/2013

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Abstract

Purpose

Pretreatment quality of life (QoL) has been used to predict survival in cancer patients. In this study, we examined the prognostic value of QoL measured after treatment on subsequent survival in patients with nasopharyngeal carcinoma (NPC).

Methods

We enrolled 273 patients with NPC who had been curatively treated for more than 1 year. The EORTC QLQ-C30 and H&N35 questionnaires were completed 1 year after radiotherapy. The predictability of QoL variables on disease-specific survival (DSS) and overall survival (OS) was analyzed using Cox’s proportional hazards models.

Results

Twenty-nine (10.6 %) patients developed locoregional relapse and 27 (9.9 %) had distant metastasis after the QoL survey with subsequent 5-year DSS and OS rates of 87.9 % and 84.0 %, respectively. Based on the QLQ-C30, scales of physical functioning, fatigue, and appetite loss significantly predicted DSS and OS (p < 0.05). In the H&N35, only sexuality was significantly correlated with DSS and OS (p < 0.05). An increment of 10 points in physical functioning (HR: 0.69; 95 % CI: 0.48–0.90; p = 0.004) or a decline of 10 points in fatigue problems (HR: 1.40; 95 % CI: 1.19–1.61; p = 0.0002), appetite loss (HR: 1.21; 95 % CI: 1.03–1.40; p = 0.02), and sexuality (HR: 1.14; 95 % CI: 1.02–1.25; p = 0.019) was associated with better OS.

Conclusion

Some QoL variables measured after the treatment provide prognostic value on subsequent survival in patients with NPC.
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Metagegevens
Titel
Prognostic value of quality of life measured after treatment on subsequent survival in patients with nasopharyngeal carcinoma
Auteurs
Wen-Ling Tsai
Chih-Yen Chien
Hsuan-Ying Huang
Kuan-Cho Liao
Fu-Min Fang
Publicatiedatum
01-05-2013
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 4/2013
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-012-0213-8

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