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Quality of Life Research
Gepubliceerd in: Quality of Life Research 8/2013

01-10-2013

Prognostic value of patient-reported symptom interference in patients with late-stage lung cancer

Auteurs: Bradley J. Barney, Xin Shelley Wang, Charles Lu, Zhongxing Liao, Valen E. Johnson, Charles S. Cleeland, Tito R. Mendoza

Gepubliceerd in: Quality of Life Research | Uitgave 8/2013

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Abstract

Purpose

Patient-reported outcomes (PROs) have been found to be significant predictors of clinical outcomes such as overall survival (OS), but the effect of demographic and clinical factors on the prognostic ability of PROs is less understood. Several PROs derived from the 12-item Short-Form Health Survey (SF-12) and M. D. Anderson Symptom Inventory (MDASI) were investigated for association with OS, with adjustments for other factors, including performance status.

Methods

A retrospective analysis was performed on data from 90 patients with stage IV non-small cell lung cancer. Several baseline PROs were added to a base Cox proportional hazards model to examine the marginal significance and improvement in model fit attributable to the PRO: mean MDASI symptom interference level; mean MDASI symptom severity level for five selected symptoms; SF-12 physical and mental component summaries; and the SF-12 general health item. Bootstrap resampling was used to assess the robustness of the findings.

Results

The MDASI mean interference level had a significant effect on OS (p = 0.007) when the model was not adjusted for interactions with other prognostic factors. Further exploration suggested the significance was due to an interaction with performance status (p = 0.001). The MDASI mean symptom severity level and the SF-12 physical component summary, mental component summary, and general health item did not have a significant effect on OS.

Conclusions

Symptom interference adds prognostic information for OS in advanced lung cancer patients with poor performance status, even when demographic and clinical prognostic factors are accounted for.
vorige artikel A prospective examination of the impact of a supported employment program and employment on health-related quality of life, handicap, and disability among Veterans with SCI
volgende artikel Confirmatory factor analysis of the PedsQL among youth in a residential treatment setting
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Metagegevens
Titel
Prognostic value of patient-reported symptom interference in patients with late-stage lung cancer
Auteurs
Bradley J. Barney
Xin Shelley Wang
Charles Lu
Zhongxing Liao
Valen E. Johnson
Charles S. Cleeland
Tito R. Mendoza
Publicatiedatum
01-10-2013
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 8/2013
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-013-0356-2

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