Download PDF
CC BY-NC-ND 4.0 · Avicenna J Med 2016; 06(04): 113-116
DOI: 10.4103/2231-0770.191448
CASE REPORT

Left ventricular noncompaction diagnosed following Graves′ disease

Habib Habib
Department of Cardiology, Saint Joseph Regional Medical Center, New York Medical College, New Jersey, USA
,
Amer Hawatmeh
Department of Cardiology, Saint Michael′s Medical Center, New York Medical College, New Jersey, USA
,
Upamanyu Rampal
Department of Cardiology, Trinitas Regional Medical Center, New York Medical College, New Jersey, USA
,
Fayez Shamoon
Department of Cardiology, Saint Michael′s Medical Center, New York Medical College, New Jersey, USA
› Author Affiliations Financial support and sponsorship Nil.
› Further Information
  PDF Download Permissions and Reprints

Abstract

Isolated left ventricular noncompaction (LVNC) is a rare genetic cardiomyopathy. Clinical manifestations are variable; patients may present with heart failure symptoms, arrhythmias, and systemic thromboembolism. However, it can also be asymptomatic. When asymptomatic, LVNC can manifest later in life after the onset of another unrelated condition. We report a case of LVNC which was diagnosed following a hyperthyroid state secondary to Graves′ disease. The association of LVNC with other noncardiac abnormalities including neurological, hematological, and endocrine abnormalities including hypothyroidism has been described in isolated case reports before. To the best of our knowledge, this is the first reported case of LVNC diagnosed following exacerbation in contractile dysfunction triggered by Graves′ disease.

Keywords

Echocardiography - Graves′ disease - noncompaction cardiomyopathy


Publication History

Article published online:
09 August 2021

© 2016. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • References

  • 1 Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, et al. Contemporary definitions and classification of the cardiomyopathies: An American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 2006;113:1807-16.
  • 2 Ritter M, Oechslin E, Sütsch G, Attenhofer C, Schneider J, Jenni R. Isolated noncompaction of the myocardium in adults. Mayo Clin Proc 1997;72:26-31.
  • 3 Oechslin EN, Attenhofer Jost CH, Rojas JR, Kaufmann PA, Jenni R. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: A distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol 2000;36:493-500.
  • 4 Gati S, Chandra N, Bennett RL, Reed M, Kervio G, Panoulas VF, et al. Increased left ventricular trabeculation in highly trained athletes: Do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes? Heart 2013;99:401-8.
  • 5 Stöllberger C, Finsterer J, Blazek G. Left ventricular hypertrabeculation/non compaction and association with additional cardiac abnormalities and neuromuscular disorders. Am J Cardiol 2002;90:899.
  • 6 Sedmera D, Pexieder T, Vuillemin M, Thompson RP, Anderson RH. Developmental patterning of the myocardium. Anat Rec 2000;258:319-37.
  • 7 Toyono M, Kondo C, Nakajima Y, Nakazawa M, Momma K, Kusakabe K. Effects of carvedilol on left ventricular function, mass, and scintigraphic findings in isolated left ventricular non-compaction. Heart 2001;86:E4.
  • 8 Markovic NS, Dimkovic N, Damjanovic T, Loncar G, Dimkovic S. Isolated ventricular non-compaction in patients with chronic renal failure. Clin Nephrol 2008;70:72-6.
  • 9 Gati S, Papadakis M, Van Niekerk N, Reed M, Yeghen T, Sharma S. Increased left ventricular trabeculation in individuals with sickle cell anaemia: Physiology or pathology? Int J Cardiol 2013;168:1658-60.
  • 10 Stähli BE, Gebhard C, Biaggi P, Klaassen S, Valsangiacomo Buechel E, Attenhofer Jost CH, et al. Left ventricular non-compaction: Prevalence in congenital heart disease. Int J Cardiol 2013;167:2477-81.
  • 11 Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 1995;378:390-4.
  • 12 Sahin G, Birdane A, Soydan M, Unalir A. Left ventricular noncompaction with hypothyroidism and sensorineural hearing loss. Anadolu Kardiyol Derg 2005;5:138-9.
  • 13 Fazio S, Palmieri EA, Lombardi G, Biondi B. Effects of thyroid hormone on the cardiovascular system. Recent Prog Horm Res 2004;59:31-50.
  • 14 Ichida F, Hamamichi Y, Miyawaki T, Ono Y, Kamiya T, Akagi T, et al. Clinical features of isolated noncompaction of the ventricular myocardium: Long-term clinical course, hemodynamic properties, and genetic background. J Am Coll Cardiol 1999;34:233-40.
  • 15 Chin TK, Perloff JK, Williams RG, Jue K, Mohrmann R. Isolated noncompaction of left ventricular myocardium. A study of eight cases. Circulation 1990;82:507-13.
  • 16 Murphy RT, Thaman R, Blanes JG, Ward D, Sevdalis E, Papra E, et al. Natural history and familial characteristics of isolated left ventricular non-compaction. Eur Heart J 2005;26:187-92.
  • 17 Engberding R, Stoellberger C, Fehske W, Gietzelt M, Haux R, Gerecke BJ. Predictors of adverse cardiac events in noncompaction cardiomyopathy: Data from the german noncompaction registrY (ALKK). J Am Coll Cardiol 2014;63(12_S): A1274. doi:10.1016/S0735-1097(14)61274-2.
  • 18 Stacey RB, Andersen MM, St Clair M, Hundley WG, Thohan V. Comparison of systolic and diastolic criteria for isolated LV noncompaction in CMR. JACC Cardiovasc Imaging 2013;6:931-40.
  • 19 Jenni R, Oechslin E, Schneider J, Attenhofer Jost C, Kaufmann PA. Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: A step towards classification as a distinct cardiomyopathy. Heart 2001;86:666-71.
  • 20 Andresen H, Kaag N, Potratz J. Non-compaction of ventricular myocardium and contrast-enhanced echocardiography. Z Kardiol 2005;94:483-5.
  • 21 Chow CM, Lim KD, Wu L, Leong-Poi H. Images in cardiovascular medicine. Isolated left ventricular noncompaction enhanced by echocontrast agent. Circulation 2007;116:e90-1.
  • 22 Fazio G, Novo G, D′Angelo L, Visconti C, Sutera L, Grassedonio E, et al. Magnetic resonance in isolated non-compaction of the ventricular myocardium. Int J Cardiol 2010 30;140:367-9.
  • 23 Jacquier A, Thuny F, Jop B, Giorgi R, Cohen F, Gaubert JY, et al. Measurement of trabeculated left ventricular mass using cardiac magnetic resonance imaging in the diagnosis of left ventricular non-compaction. Eur Heart J 2010;31:1098-104.
  • 24 Kobza R, Jenni R, Erne P, Oechslin E, Duru F. Implantable cardioverter-defibrillators in patients with left ventricular noncompaction. Pacing Clin Electrophysiol 2008;31:461-7.
  • 25 Kobza R, Steffel J, Erne P, Schoenenberger AW, Hürlimann D, Lüscher TF, et al. Implantable cardioverter-defibrillator and cardiac resynchronization therapy in patients with left ventricular noncompaction. Heart Rhythm 2010;7:1545-9.