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CC BY-NC-ND 4.0 · Eur J Dent 2015; 09(01): 060-065
DOI: 10.4103/1305-7456.149644
Original Article
Dental Investigation Society

Crevicular fluid levels of interleukin-8, interleukin-17 and soluble intercellular adhesion molecule-1 after regenerative periodontal therapy

Ebru Olgun Erdemir
1   Department of Periodontology, Faculty of Dentistry, Kirikkale University, Merkez, Kirikkale, Turkiye
,
Meltem Karsiyaka Hendek
1   Department of Periodontology, Faculty of Dentistry, Kirikkale University, Merkez, Kirikkale, Turkiye
,
H. Gencay Keceli
2   Department of Periodontology, Faculty of Dentistry, Hacettepe University, Sıhhiye, Ankara, Turkiye
,
Teoman Z. Apan
3   Department of Medical Microbiology, Faculty of Medicine, Kirikkale University, Merkez, Kirikkale, Turkiye
› Author Affiliations
Further Information

Publication History

Publication Date:
04 September 2019 (online)

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ABSTRACT

Objective: The aim of this study is to evaluate the influence of regenerative periodontal therapy on clinical parameters and interleukin-8 (IL-8), IL-17 and soluble intercellular adhesion molecule-1 (sICAM-1) levels in gingival crevicular fluid (GCF) of subjects with chronic periodontitis (CP). Materials and Methods: Fifteen patients received demineralized freeze-dried bone allograft (DFDBA) surgically to the site of infrabony defect. Clinical periodontal indices were recorded, and GCF samples were collected at baseline and at the 6th and the 9th month after the surgery. Results: Except plaque index, all clinical parameters improved following surgery (P < 0.05). The volume of GCF diminished from baseline to follow-up periods (P < 0.05). However, no effect was observed on the total amount of IL-8, IL-17 and sICAM-1 in GCF. Conclusion: DFDBA improved clinical outcome in CP subjects and was effective on decreasing the volume of GCF, but no effect was determined on IL-8, IL-17 and sICAM-1. Findings did not indicate a direct relationship between biochemical parameters and periodontal healing after demineralized freeze-dried bone grafting.

Key words:

Demineralized freeze-dried bone allograft - gingival crevicular fluid - interleukin-17 - interleukin-8 - soluble intercellular adhesion molecule-1
 

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