The History of the AutoChemist^®: From Vision to Reality

 

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Summary

Objectives: This paper discusses the early history and development of a clinical analyser system in Sweden (AutoChemist, 1965). It highlights the importance of such high capacity system both for clinical use and health care screening. The device was developed to assure the quality of results and to automatically handle the orders, store the results in digital form for later statistical analyses and distribute the results to the patients’ physicians by using the computer used for the analyser.

Results: The most important result of the construction of an analyser able to produce analytical results on a mass scale was the development of a mechanical multi-channel analyser for clinical laboratories that handled discrete sample technology and could prevent carry-over to the next test samples while incorporating computer technology to improve the quality of test results. The AutoChemist could handle 135 samples per hour in an 8-hour shift and up to 24 possible analyses channels resulting in 3,200 results per hour. Later versions would double this capacity. Some customers used the equipment 24 hours per day.

Conclusions: With a capacity of 3,000 to 6,000 analyses per hour, pneumatic driven pipettes, special units for corrosive liquids or special activities, and an integrated computer, the AutoChemist system was unique and the largest of its kind for many years. Its follower – The AutoChemist PRISMA (PRogrammable Individually Selective Modular Analyzer) – was smaller in size but had a higher capacity. Both analysers established new standards of operation for clinical laboratories and encouraged others to use new technologies for building new analysers.

• References

• 1 Schmidt RM. George Zur Williams – biographical description. Symposium in Honor of George Z. Williams. Methods Inf Med 1993; Apr 32 (Suppl. 03) 242-4.
  PubMedGoogle Scholar
• 2 Williams GZ. The use of data processing and automation in clinical pathology. Mil Med 1964; 129: 502-9.
  CrossrefPubMedGoogle Scholar
• 3 Sobota JT, Brewer D, Cummings ME, Feld BSM, Williams GZ. A data processing system for hematology. Presented at the annual meeting of the American Society of Clinical Pathologists, Bal Harbour, Florida, October 21 1964
  PubMedGoogle Scholar
• 4 Williams GZ. Research today is routine tomorrow. Ala J Med Sci 1965; 2: 319-22.
  PubMedGoogle Scholar
• 5 Williams GZ. Automation in Clinical Laboratories. In: Dickson III JF, Brown JHU. editors. Future Goals of Engineering in Biology and Medicine. Proceedings of an International Conference. Washington, D.C., September 1967. New York, London: Academic Press; 1969. p. 222-6.
  Google Scholar
• 6 Peacock AC, Bunting SL, Brewer D, Cotlove E, Williams GZ. A data processing system for clinical chemistry. Biomed Sci Instr 1963; 1: 33-8.
  PubMedGoogle Scholar
• 7 Peacock AC, Bunting SL, Brewer D, Cotlove E, Williams GZ. Data processing in clinical chemistry. Clin Chem 1965; 11: 595-611.
  PubMedGoogle Scholar
• 8 Hospital Computer Project.. A Joint Research Effort of the Massachusetts General Hospital and Bolt, Beranek and Newman, Cambridge, Massachusetts. Principal Investigator Jordan J Baruch. Memorandum Number Six-D. Information Storage and Retrieval System Status Report. Sep.1, 1967
  PubMedGoogle Scholar
• 9 The four references below [10-13] are published in Proceedings on Automated-Data Processing in Hospitals, Elsinore, Denmark April-May 1966. Of the totally 41 invited speakers 21 were from USA, 7 from France, 6 from Sweden, 2 from Great Britain and The Netherlands, 1 from Germany, Poland, Japan, Puerto Rico and Norway together with 7 from the host country Denmark.
  PubMed
• 10 Kirkham WR, Cotlove E, Williams GZ, Allen SI. Automation of Hospital Laboratory Services as part of a Modular Approach to Hospital Automation and Data Processing, p. 255-66.
  PubMedGoogle Scholar
• 11 Baruch JJ. Medical Time-Sharing System. p. 180-89.
  PubMedGoogle Scholar
• 12 Jungner G. Data Processing in the Clinical Laboratory. p. 235-51.
  PubMedGoogle Scholar
• 13 Jungner G. Health Screening. p. 48-71.
  PubMedGoogle Scholar
• 14 Jungner G, Jungner I. Chemical Health Screening. In: Sharp CLEH, Keen H. editors. Presymptomatic Detection and Early Diagnosis: A Critical Appraisal. London: Pitman Medical Publishing Co. Ltd.; 1968. p. 67-108.
  Google Scholar
• 15 Jungner I. “Berättelse om AutoChemisten”. Etapp 3:2. Apparatsystem för automatisk blodanalys med ett fast analysprogram för kemisk hälsokontroll – Värmlandsapparaturen; 2005. [A system for automatic blood analyses with a fixed program for health control – the Värmland apparatus (Chapter 2 in the article ”The story about the AutoChemist”)]. www.tekniskamuseet.se Available only in Swedish).
  PubMedGoogle Scholar
• 16 The Swedish National Board of Health and Welfare: Report by G Jungner to the 14th Session of the Regional Committee for Europe of the WHO, Prague, September 22-26, 1964. Health Screening Project in Värmland – A pilot study on Mass Screening with Application of a Chemical Test Battery. www.tekniskamuseet.se
  PubMedGoogle Scholar
• 17 Jungner I. Hälsokontroll (IV): Erfarenheter från Värmlandsundersökningen [Experiences from the Värmland study.] In: Health Screening (IV). Läkartidningen 1966; 63: 2602-08. (Available only in Swedish).
  PubMedGoogle Scholar
• 18 National Board for Health and Welfare, Stockholm: The Värmland Survey.. No.23. Stockholm: 1971
  PubMedGoogle Scholar
• 19 Engel A. Mass Screening for Asymptomatic Disease as a Public Health Measure. In: Perspectives in Health Planning. University of London, The Athlone Press; 1968. p. 47-69
  Google Scholar
• 20 Engel A, Malmström G. The Värmland trial, a mass health screening project. Acta Sociomed Scand 1969; 2: 61-8.
  PubMedGoogle Scholar
• 21 Jungner G, Jungner I. Försöksverksamhet för prövning av sjukhusautomation. I. Grunddragen i Epidemisjukhusprojektet. [Inquiry into hospital automation. 1. Fundamental features of the so-called Infectious Disease Hospital project] Sjukhuset 1965; 42 (Suppl. 04) 81-7. (Available only in Swedish).
  PubMedGoogle Scholar
• 22 Jungner G, Jungner I. Försöksverksamhet för prövning av sjukhusautomation. II. Om de tekniska hjälpmedlen för den automatiserade laboratorieverksamheten i Epidemisjukhusprojektet. [Inquiry into hospital automation II. The technical set up for the test at the Hospital for Infectious Diseases.] Sjukhuset 1965; 42 (Suppl. 06) 172-80. (Available only in Swedish).
  PubMedGoogle Scholar
• 23 Jungner G, Jungner I, Peterson H. Rapport till SJURA över projekt 404, Epidemisjukhus-projektet. Om sjukhusautomation. Försöksverksamhet utgående från centraliserad laboratorie-automation [About hospital automation. Research emanated from centralized laboratory automation. SJURA report no. 404, the so-called Infectious Disease Hospital Project]; 1967 (Available only in Swedish).
  PubMedGoogle Scholar
• 24 Peterson HE, Lundin P. Documenting the use of computers in Swedish health care up to 1980. Yearb Med Inform 2011; 169-74.
  Article in Thieme ConnectPubMedGoogle Scholar
• 25 Peterson H. The PDP-8´s role in the AutoChemist system. The Digital Equipment Computer Users Society, Spring Symposium, Boston Mass., May 23-25 1966 p. 15-20. www.tekniskamuseet.se
  PubMedGoogle Scholar
• 26 Ohlsén L, Jungner I, Peterson HE. The History of the data system AutoChemist® (ACH) and AutoChemist-PRISMA (PRISMA®): from 1964 to 1986. Yearb Med Inform 2014; 244-54.
  Article in Thieme ConnectPubMedGoogle Scholar
• 27 Jungner I, Jungner G. The AutoChemist as a laboratory screening instrument. In: Benson ES, Strandjord P. Multiple Laboratory Screening. New York: Academic Press; 1969. p. 71-86.
  Google Scholar
• 28 Jungner G. Automation in Clinical Laboratories. II. In: Dickson III JF, Brown JHU. Future Goals of Engineering in Biology and Medicine. Proceedings of an International Conference, held in Washington, D.C., September 1967. New York and London: Academic Press; 1969. p. 227-31.
  Google Scholar
• 29 Jungner G. Multiphasic Laboratory Screening by Multi-Channel Automated Equipment. In: Early Disease Detection. Miami, Florida: Halos & Associates, Medical Book Division.; 1970. p. 4-11.
  Google Scholar
• 30 Jungner G. The AutoChemist´s Performance. In: Berkley C. editor. Proceedings of an International Conference on Engineering in Medicine-Automated Multiphasic Health Testing (AMHT) held in Davos, Switzerland, September 14-18, 1970. New York City, NY, USA: Engineering Foundation; 1971. p. 116-23.
  Google Scholar
• 31 Jungner G. Guidelines for AMHT Facilities, ibid. 247-51.
  PubMedGoogle Scholar
• 32 Jungner G. Choice of biochemical profile tests, ibid. 369-81.
  PubMedGoogle Scholar
• 33 Jungner I. ”Berättelse om AutoChemisten” [The story about the AutoChemist ]; 2005. www.tekniskamuseet.se (Available only in Swedish).
  PubMedGoogle Scholar
• 34 Jungner I. The AutoChemist – the first on-line computerized analyzer for mass-analysis and multiple screening. The History Division of AACC Vol 19. 03 2011
  PubMedGoogle Scholar
• 35 Jungner G, Jungner I. A push-button starting analytical robot. Digest of the 7th Int. Conference on Medical and Biological Engineering Stockholm: August 15, 1967 p. 190.
  PubMedGoogle Scholar
• 36 Jungner G, Jungner I. Interpretation of data obtained in laboratory screening programs. In: Benson ES, Strandjord P. editors. Multiple Laboratory Screening. New York: Academic Press; 1969: 257-91.
  Google Scholar
• 37 Wilson JMG, Jungner G. Principles and Practice of Screening for Disease. Geneva, Switzerland: World Health Organisation. Public Health Paper No. 34; 1968
  Google Scholar
• 38 Wilding P. BUPA Medical Centre.. Experience in the use of the AGA AutoChemist. 11 Congresse Nationale di Biochimica Clinica, Padova, Italy, May 25-27; 1972
  PubMedGoogle Scholar
• 39 Wilding P. The Role of the Automated Laboratory within a Multiphasic Health Screening Center. Med Progr Technol 1972; 1 (Suppl. 01) 45-51.
  PubMedGoogle Scholar
• 40 Wilding P, Rollason JG, Robinson D. Patterns of change for various biochemical constituents detected in well population screening. Clin Chim Acta 1972; 41: 375-87.
  CrossrefPubMedGoogle Scholar
• 41 Baily A. Biochemistry of well population. The Lancet 1974; 14: 1436-43.
  PubMedGoogle Scholar
• 42 Bokelund H. A Review of the AutoChemist System in a Hospital Environment. Scand J Clin Lab Invest Suppl 1974; 140: 9-26.
  PubMedGoogle Scholar
• 43 Valdiguié P, de la Farge F, Solera M-L. Utilisation hospitalière d’un AutoChemist Bilan des six premiers mois. [The Hospital use of the AutoChemist during the first six months] Organisation des Laboratoires – Biologie Prospective 11e Colloque de Pont-à-Mousson; 1972 p. 237-40.
  PubMedGoogle Scholar
• 44 Revolutionary 30 channel testing system.. United Medical Laboratories: UML. NEWS 1969; 1 (Suppl. 01) 5-11. www.tekniskamuseet.se and ICN/United Medical Laboratories – The World´s Largest; 1973. www.tekniskamuseet.se
  PubMedGoogle Scholar
• 45 Dexter CV, Larsen M. Centralized Large-Scale Clinical Testing in a Commercial Environment. Proceedings of the IEEE 1969; 57 (Suppl. 11) 1988-95.
  CrossrefPubMedGoogle Scholar
• 46 MetPath Inc., Teterboro, New Jersey, USA.. Annual Report 1975. www.tekniskamuseet.se and Annual Report 1978 www.tekniskamuseet.se and Setting the Pace in Laboratory Services; 1979 www.tekniskamuseet.se
  PubMedGoogle Scholar
• 47 Wakabayashi M. [AutoChemist, in Japanese]. Japan J Clin Chem 1972; 1 (Suppl. 03) 300-7 (the journal name in Japanese is: Rinsho kagaku – ISSN-0303-56333)
  PubMedGoogle Scholar
• 48 Yamamoto M, Uchida K, Wakabayashi M. Computerized central clinical laboratories in some medical centres. Proc Medis´73, Osaka; 1973; 170-2.
  PubMedGoogle Scholar
• 49 Hammar L. PRISMA- Ett IT project I Svensk laboratorieautomation. [PRISMA- A Swedish laboratory automation IT project. A report to the project “From Calculators to IT- lessons from Swedish IT history.] Available only in Swedish at www.historiskamuseet.se
  PubMedGoogle Scholar
• 50 AutoChem Instrument AB: A unique system for the automation of clinical chemistry, AutoChemist – PRISMA the first truly flexible multichannel analyzer system; 1975. www.tekniskamuseet.se and PRISMA – The new generation of clinical analysis system Bromma/Sweden: Clinicon; 1983 www.tekniskamuseet.se
  PubMed