Thromb Haemost 2007; 98(02): 477-478
DOI: 10.1160/TH06-12-0702
Letters to the Editor
Schattauer GmbH

Persistence of phosphatidylserine exposure on activated platelets in vivoin rabbits

Margaret L. Rand
1   Division of Haematology/Oncology and Program in Physiology and Experimental Medicine, The Hospital for Sick Children
2   Department of Laboratory Medicine and Pathobiology
3   Department of Biochemistry, University of Toronto
,
Hong Wang
1   Division of Haematology/Oncology and Program in Physiology and Experimental Medicine, The Hospital for Sick Children
,
Annie K. W. Bang
4   Division of Transfusion Medicine, St. Michael’s Hospital
,
Marian A. Packham
3   Department of Biochemistry, University of Toronto
,
John Freedman
5   Department of Medicine, University of Toronto; Toronto, Canada
4   Division of Transfusion Medicine, St. Michael’s Hospital
5   Department of Medicine, University of Toronto; Toronto, Canada
› Author Affiliations
Financial support: This work was supported by grant T5389 from the Heart and Stroke Foundation of Ontario.
Further Information

Publication History

Received 07 December 2006

Accepted after resubmission 25 May 2007

Publication Date:
28 November 2017 (online)

 

 
  • References

  • 1 Zwaal RF, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997; 89: 1121-1132.
  • 2 Heemskerk JW, Bevers EM, Lindhout T. Platelet activation and blood coagulation. Thromb Haemost 2002; 88: 186-193.
  • 3 Leung R, Gwozdz AM, Wang H. et al. Persistence of procoagulant surface expression on activated human platelets: involvement of apoptosis and aminophospholipid translocase activity. J Thromb Haemost 2007; 5: 560-570.
  • 4 Rand ML, Wang H, Bang KW. et al. Procoagulant surface exposure and apoptosis in rabbit platelets: association with shortened survival and steady-state senescence. J Thromb Haemost 2004; 2: 651-659.
  • 5 Berger G, Hartwell DW, Wagner DD. Platelet death. An apoptotic-like process? Blood 1998; 92: 347a.
  • 6 Martin SJ, Reutelingsperger CP, McGahon AJ. et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995; 182: 1545-1556.
  • 7 Kuypers FA, de Jong K. The role of phosphatidylserine in recognition and removal of erythrocytes. Cell Mol Biol 2004; 50: 147-158.
  • 8 Castedo M, Hirsch T, Susin SA. et al. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. J Immunol 1996; 157: 512-521.
  • 9 Rand ML, Wang H, Bang KW. et al. Rapid clearance of procoagulant platelet-derived microparticles from the circulation of rabbits. J Thromb Haemost 2006; 4: 1621-1623.
  • 10 Kinlough-Rathbone RL, Perry DW. Prolonged expression of procoagulant activity of human platelets degranulated by thrombin. Thromb Haemost 1995; 74: 958-961.