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Semin Reprod Med 1997; 15(1): 91-100
DOI: 10.1055/s-2008-1067971
Copyright © 1997 by Thieme Medical Publishers, Inc.

The Perimenopause and Affective Disorders

Peter J. Schmidt, Catherine A. Roca, Miki Bloch, David R. Rubinow
  • Behavioral Endocrinology Branch National Institute of Mental Health, Bethesda, Maryland
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Publication History

Publication Date:
15 March 2008 (online)

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Abstract

A variety of epidemiologic studies have identified that the majority of postmenopausal women do not experience a depression during the perimenopause. In contrast, results of several epidemiologic studies and clinic-based surveys suggest that a substantial number of perimenopausal women, in fact, do experience a clinically significant depression. In this article, we review these studies. Case examples are described to introduce a discussion of the characteristics of perimenopause-related depression, and we identify several factors occurring during midlife in women that may potentially contribute to mood dysregulation at this time. Finally, we provide suggestions for the evaluation and management of women presenting with perimenopause-related depression.

Keywords:

Depression - midlife - perimenopause

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