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Thorac Cardiovasc Surg 1985; 33(3): 176-178
DOI: 10.1055/s-2007-1014111
© Georg Thieme Verlag Stuttgart · New York

Plasma Fibronectin, Albumin, IgM and Total Protein during Cardiopulmonary Bypass

J. Miholic1 , W. Graninger2 , M. Havel1 , W. Klepetko1 , G. Laufer1 , W. Sandtner3
  • 1Surgical Clinic 2,
  • 2Clinic for Chemotherapy, and
  • 3Clinic for Anaesthesia and General Intensive Care, University of Vienna Medical School, Vienna, Austria
Further Information

Publication History

1985

Publication Date:
08 May 2008 (online)

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Summary

Plasma concentrations of fibronectin, albumin, total protein and IgM were measured in 14 male patients undergoing aorto-coronary bypass operations. Fibronectin and IgM concentrations feil to 55% of the preoperative values 5 minutes after start of the extracorporeal circulation, and the same percentages were encountered 5 minutes after the termination of bypass. The concentrations had recovered to 75% of the preoperative values by the end of the operation. The plasma concentration of albumin was 68 ± 9% of the preoperative value after 5 minutes of bypass, 66 ± 7 % at the end of bypass, and 83 ± 9% of the end of operation (signifi-cantly different from fibronectin and IgM, p < 0.05; Wilcoxon's test for paired differences). No correlation was found between the duration of extracorporeal circulation and the post-bypass concentrations of any protein (Kendali correlation). It is concluded that the fall of fibronectin concentrations during cardiopulmonary bypass can be sufficiently explained by dilution, and that a specific consumption of fibronectin does not occur. The less marked decreases of albumin and total protein were probably due to infusion of plasma-protein solution, which is poor in fibronectin and IgM.

Key words

Fibronectin - IgM - Extracorporeal circulation - Aorto-coronary bypass

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