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Horm Metab Res 2003; 35(1): 24-28
DOI: 10.1055/s-2003-38387
Original Basic
© Georg Thieme Verlag Stuttgart · New York

Dinucleotide Polymorphisms Present in the 5’-Flanking Region of the Human H2 Relaxin Gene, but not in the Corresponding Region of the H1 Gene

A.  V.  D'Elia 1 , L.  Pellizzari 1 , C.  Puppin 1 , L.  Driul 2 , D.  Marchesoni 2 , G.  Damante 1
  • 1Dipartimento di Scienze e Tecnologie Biomediche, Università di Udine, Italy
  • 2Clinica Ostetrica e Ginecologica, Policlinico Universitario, Udine, Italy
Further Information

Publication History

Received 4 March 2002

Accepted after revision 30 July 2002

Publication Date:
01 April 2003 (online)

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Abstract

Relaxin is a peptide hormone that, in humans, is encoded by two genes referred to as H1 and H2, both located into chromosome 9p24.1. We have searched for polymorphisms in the 5’-flanking sequence of these genes. Both genes possess a CT repeat followed by a GT repeat. CT and GT repeats of the H2 gene are longer than those of the H1 gene. Moreover, CT and GT repeats of the H2 gene, but not those of the H1 gene, show length polymorphism. Protein-DNA interaction experiments suggest that difference between the H1 and H2 GT repeats may have arisen because the requirements of the transcriptional regulation of the two genes are different.

Key words

Polymorphisms - Microsatellites - Relaxin - Protein-DNA Interaction

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Prof. G. Damante

Dipartimento di Scienze e Tecnologie Biomediche

Piazzale Kolbe 1 · 33100 Udine · Italy

Phone: + 39 (432) 49 43 74

Fax: + 39 (432) 49 43 79

Email: GDamante@makek.dstb.uniud.it

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