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CC BY-NC-ND 4.0 · South Asian J Cancer 2024; 13(01): 077-082
DOI: 10.1055/s-0043-1778685
Original Article
Gastrointestinal Cancers

Practical Consensus Guidelines for the Use of S-1 in GI Malignancies

Purvish M Parikh
1   Department of Clinical Hematology, Mahatma Gandhi University of Medical Sciences & Technology, Jaipur, Rajasthan, India
,
Tarini P. Sahoo
2   Department of Medical Oncology, Silverline Hospital, Bhopal, Madhya Pradesh, India
,
Ghanashyam Biswas
3   Department of Medical Oncology, Sparsh Hospitals & Critical Care Pvt. Ltd., Bhubaneswar, Odisha, India
,
Vineet Talwar 
4   Department of Medical Oncology, Rajiv Gandhi Cancer Institute, Delhi, India
,
Somashekhar SP 
5   Department of Surgical Oncology, Aster International Institute of Oncology, Bengaluru, Karnataka, India
,
Soumya Surath Panda
6   Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Bhubaneswar, Odisha, India
,
Avinash CB
7   Department of Medical Oncology, ClearMedi Radiant Hospital, Mysuru, Karnataka, India
,
Nishita Shetty
8   Department of Medical Oncology, Father Muller Medical College Hospital, Mangalore, Karnataka, India
,
Anita Ramesh
9   Department of Medical Oncology, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India
,
Joydeep Ghosh
10   Department of Medical Oncology, Tata Medical Center, Kolkata, West Bengal, India
,
Vijith Vital Shetty
11   Department of Medical Oncology, K S Hegde Medical Academy, Mangalore, Karnataka, India
,
Radheshyam Naik
12   Department of Medical Oncology, HCG Hospital, Bengaluru, Karnataka, India
,
Ashish Singh
13   Department of Medical Oncology, Christian Medical College, Vellore, Karnataka, India
,
Gaurav Gupta
14   Department of Medical Oncology, Optimus Oncology Center, Lucknow, Uttar Pradesh, India
,
Bhavesh Parekh
15   Department of Medical Oncology, Marengo CIMS Hospital, Ahmedabad, Gujrat, India
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Abstract

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Purvish M Parikh

S-1 (5-fluorouracil prodrug [tegafur] in combination with 5-chloro-2,4-dihydroxypyridine [CDHP] and potassium oxonate [OXO]) was first approved in 1999. In order to make it easy for community oncologists, we decided to put together this expert consensus guideline for its use in gastrointestinal (GI) malignancies. A total of 15 subject matter experts used modified Delphi method to discuss, analyze, and vote on key aspects regarding practical approach to use of S-1 in GI cancers, a process involving 6 months of work. The consensus guidelines specify how S-1 use can be optimized in patients with colorectal, gastric, and pancreatic tumors. The voting for the 17 key points resulted in a majority consensus for all the statements (approval ranging from 13/15 [87%] to 15/15 [100%]). S-1 is a combination of three drugs (tegafur, CDHP, and OXO) specifically designed to reduce toxicity and enhance efficacy; clinical data and meta-analysis confirm both factors; and it is recommended as standard of care for GI cancers. S-1 is approved and one of the standards of care for all lines of therapy in colorectal cancer and pancreatic cancers. S-1 with oxaliplatin is the standard of care for gastric cancers.

Keywords

SCOPE-C - IASCO - Tegafur - OXO - CDHP - SAARC


Publication History

Article published online:
05 February 2024

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