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CC BY 4.0 · Rev Bras Ginecol Obstet 2023; 45(12): e754-e763
DOI: 10.1055/s-0043-1772593
Original Article
High Risk Pregnancy

Prediction of Preterm Delivery Using Serum Ischemia Modified Albumin, Biglycan, and Decorin Levels in Women with Threatened Preterm Labor

Previsão de parto prematuro usando albumina modificada por isquemia sérica, biglicano e níveis de decorina em mulheres com ameaça de trabalho de parto prematuro
Ismail Biyik 
1   Department of Obstetrics and Gynecology, School of Medicine, Kutahya Health Sciences University, Kutahya, Turkey
,
Cenk Soysal 
1   Department of Obstetrics and Gynecology, School of Medicine, Kutahya Health Sciences University, Kutahya, Turkey
,
Ozlem Ulas Onur Ince 
1   Department of Obstetrics and Gynecology, School of Medicine, Kutahya Health Sciences University, Kutahya, Turkey
2   Department of Statistics, Faculty of Arts and Sciences, Middle East Technical University, Ankara, Turkey
,
Sinem Durmus 
3   Department of Medical Biochemistry, School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey
,
Efser Oztas 
1   Department of Obstetrics and Gynecology, School of Medicine, Kutahya Health Sciences University, Kutahya, Turkey
,
Nadi Keskin 
1   Department of Obstetrics and Gynecology, School of Medicine, Kutahya Health Sciences University, Kutahya, Turkey
,
Ozben Ozden Isiklar 
4   Department of Medical Biochemistry, School of Medicine, Kutahya Health Sciences University, Kutahya, Turkey
,
Oğuz Han Karaagac 
1   Department of Obstetrics and Gynecology, School of Medicine, Kutahya Health Sciences University, Kutahya, Turkey
,
Remise Gelisgen 
3   Department of Medical Biochemistry, School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey
,
Hafize Uzun 
5   Department of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas University, Istanbul, Turkey
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Abstract

Objective The serum ischemia modified albumin (IMA), biglycan, and decorin levels of pregnant women who were hospitalized for threatened preterm labor were measured.

Methods Fifty-one consecutive pregnant women with a single pregnancy between the 24th and 36th weeks with a diagnosis of threatened preterm labor were included in the present prospective cohort study.

Results As a result of multivariate logistic regression analysis for predicting preterm delivery within 24 hours, 48 hours, 7 days, 14 days, ≤ 35 gestational weeks, and ≤ 37 gestational weeks after admission, area under the curve (AUC) (95% confidence interval [CI[) values were 0.95 (0.89–1.00), 0.93 (0.86–0.99), 0.91 (0.83–0.98), 0.92 (0.85–0.99), 0.82 (0.69–0.96), and 0.89 (0.80–0.98), respectively. In the present study, IMA and biglycan levels were found to be higher and decorin levels lower in women admitted to the hospital with threatened preterm labor and who gave preterm birth within 48 hours compared with those who gave birth after 48 hours.

Conclusion In pregnant women admitted to the hospital with threatened preterm labor, the prediction preterm delivery of the combined model created by adding IMA, decorin, and biglycan in addition to the TVS CL measurement was higher than the TVS CL measurement alone.

Clinical trial registration The present trial was registered at ClinicalTrials.gov, number NCT04451928.

Resumo

Objetivo Medir os níveis séricos de albumina modificada por isquemia (IMA), biglicano e decorina de gestantes hospitalizadas por ameaça de parto prematuro.

Métodos Cinquenta e uma mulheres grávidas consecutivas com uma única gravidez entre a 24ª e a 36ª semanas com diagnóstico de ameaça de trabalho de parto prematuro foram incluídas no presente estudo de corte prospectivo.

Resultados Como resultado da análise de regressão logística multivariada para prever parto prematuro dentro de 24 horas, 48 horas, 7 dias, 14 dias, ≤ 35 semanas gestacionais e ≤ 37 semanas gestacionais após a admissão, área sob a curva (AUC) (95% de confiança os valores de intervalo [CI[) foram 0,95 (0,89–1,00), 0,93 (0,86–0,99), 0,91 (0,83–0,98), 0,92 (0,85–0,99), 0,82 (0,69–0,96) e 0,89 (0,80–0,98), respectivamente. No presente estudo, os níveis de IMA e biglican foram maiores e os níveis de decorin menores em mulheres admitidas no hospital com ameaça de trabalho de parto prematuro e que tiveram parto prematuro em 48 horas em comparação com aquelas que deram à luz após 48 horas.

Conclusão Em gestantes admitidas no hospital com ameaça de trabalho de parto prematuro, a predição de parto prematuro do modelo combinado criado pela adição de IMA, decorin e biglican, além da medição do TVS CL, foi maior do que a medição do TVS CL isoladamente.

Registro do ensaio clínico O presente ensaio foi registrado em ClinicalTrials.gov, número NCT04451928.

Keywords

ischemia modified albumin - biglycan decorin - preterm delivery prediction - threatened preterm labor - preterm delivery

Palavras-chave

albumina modificada por isquemia - biglicano decorina - previsão de parto prematuro - ameaça de parto prematuro - parto prematuro

Contributions

Surgical and medical practices: Biyik I., Soysal C., OU, OI, Karaagac O. H.; Concept and design: Biyik I., Oztas E., Keskin N., Gelisgen R., Uzun H.; Data collection or processing: Biyik I., Soysal C., OU, Karaagac O. H., Durmus S., Isiklar O. O.; Analysis or interpretation: Biyik I., OI, Oztas E., Isiklar O. O.; Literature search: Biyik I., Durmus S., Gelisgen R., Uzun H.; Writing: Biyik I., Oztas E., Keskin N..




Publication History

Received: 08 April 2023

Accepted: 21 June 2023

Article published online:
23 December 2023

© 2023. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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