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Thromb Haemost 1993; 70(03): 475-480
DOI: 10.1055/s-0038-1649608
Original Article
Fibrinolysis
Schattauer GmbH Stuttgart

Antigens of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1: Correlates in Nonsmoking Japanese and Caucasian Men and Women

Hiroyasu Iso
1   The Institute of Community Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki-ken, Japan
,
Aaron R Folsom
2   The Division of Epidemiology, School of Public Health, University of Minnesota, Suite 300, Minneapolis, MN, USA
,
Kazuko A Koike
1   The Institute of Community Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki-ken, Japan
,
Shinichi Sato
3   The Department of Epidemiology and Mass Examination, The Center for Adult Diseases, Osaka, Higashinariku, Osaka, Japan
,
Kenneth K Wu
4   The Department of Internal Medicine, Division of Hematology/Oncology, The University of Texas, Health Science Center at Houston, Houston, Texas, USA
,
Takashi Shimamoto
1   The Institute of Community Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki-ken, Japan
,
Minoru Iida
3   The Department of Epidemiology and Mass Examination, The Center for Adult Diseases, Osaka, Higashinariku, Osaka, Japan
,
Yoshio Komachi
5   The Osaka Prefectural Institute of Public Health, Higashinariku, Osaka, Japan
› Author Affiliations
Further Information

Publication History

Received 12 October 1992

Accepted after revision 05 April 1993

Publication Date:
05 July 2018 (online)

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Summary

We reported in a 1987 preliminary study that tissue plasminogen activator antigen was significantly higher in American Caucasian men than in Japanese men. To further examine possible differences in fibrinolytic activity between the two races, an expanded study was conducted in a total of 300 nonsmoking men and women aged 47-69 years in two population-based samples: rural Japanese living in Akita and Caucasians living in Minneapolis-St. Paul, MN. Antigens of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) were measured. Mean t-PA antigen was 2.3 ng/ml higher in Caucasian men than in Japanese men (P <0.001), but no race difference was seen for women (P = 0.59). Mean PAI-1 was higher in Caucasians than in Japanese for both sexes, and the race difference in mean was 1.8 ng/ml for men (P = 0.07) and 4.4 ng/ml for women (P <0.001). Both t-PA and PAI-1 were associated positively with body mass index and blood triglycerides for all sex-race groups, and positively with alcohol intake for Japanese and Caucasian men. Compared to Japanese, Caucasians of both sexes had higher levels of body mass index and blood triglycerides, and lower average intake of alcohol among men. Even when adjusted for body mass index, triglycerides, alcohol and other cardiovascular risk factors, the race difference in mean t-PA antigen persisted for men (P <0.001), as did the difference in mean PAI-1 for men (P = 0.03) and women (P = 0.001). If PAI-1 is a risk factor for coronary heart disease, a higher level in Caucasians than Japanese would correspond to the higher mortality rate from coronary heart disease in the United States than in Japan.

 

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