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Thromb Haemost 1992; 67(01): 016-018
DOI: 10.1055/s-0038-1648372
Original Articles
Schattauer GmbH Stuttgart

Hereditary Cerebral Hemorrhage with Amyloidosis -Dutch Type: A Study of Fibrinolysis

J Haan
1   Department of Neurology, University Hospital Leiden, The Netherlands
,
C Kluft
2   The Gaubius Institute TNO, Leiden, The Netherlands
,
F W G Leebeek
2   The Gaubius Institute TNO, Leiden, The Netherlands
,
A C W de Bart
2   The Gaubius Institute TNO, Leiden, The Netherlands
,
O J S Buruma
1   Department of Neurology, University Hospital Leiden, The Netherlands
,
R A C Roos
1   Department of Neurology, University Hospital Leiden, The Netherlands
*   Members of the Research-Group on Hereditary Cerebral Amyloid Angiopathy, Leiden
› Author Affiliations
Further Information

Publication History

Received 03 April 1991

Accepted after revision 25 July 1991

Publication Date:
02 July 2018 (online)

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Summary

In view of reported associations between increased bleeding tendency and systemically decreased α2-antiplasmin in patients with systemic amyloid deposition we studied α2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with hereditary cerebral hemorrhage with amyloidosis - Dutch type (HCHWA-D).

None of the factors measured in the quiescent phase of the disease was abnormal. In the acute phase, shortly after a stroke, only factor VIII: Ag was evidently elevated. We concluded that systemic abnormalities in the part of the fibrinolysis system studied are not likely to be responsible for multifocal and recurrent cerebral hemorrhages in HCHWA-D. The role of an elevated factor VIII: Ag level in the acute phase is unclear.

 

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