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Thromb Haemost 2000; 84(01): 138-139
DOI: 10.1055/s-0037-1613983
Letters to the Editor
Schattauer GmbH

Activated Protein C (APC) Resistance: Considerations about the Importance of Using the Original and Modified Methods in Thrombophilic Disease

Laura Gennari
1   From the Departamento de Hemostasia y Trombosis, Instituto de Investigaciones Hematológicas “Mariano R. Castex”, Academia Nacional de Medicina, Buenos Aires, Argentina
,
Alicia N. Blanco
1   From the Departamento de Hemostasia y Trombosis, Instituto de Investigaciones Hematológicas “Mariano R. Castex”, Academia Nacional de Medicina, Buenos Aires, Argentina
,
Emilse Bermejo
1   From the Departamento de Hemostasia y Trombosis, Instituto de Investigaciones Hematológicas “Mariano R. Castex”, Academia Nacional de Medicina, Buenos Aires, Argentina
,
Julieta Salviú
1   From the Departamento de Hemostasia y Trombosis, Instituto de Investigaciones Hematológicas “Mariano R. Castex”, Academia Nacional de Medicina, Buenos Aires, Argentina
,
Silvia Grosso
1   From the Departamento de Hemostasia y Trombosis, Instituto de Investigaciones Hematológicas “Mariano R. Castex”, Academia Nacional de Medicina, Buenos Aires, Argentina
,
María A. Lazzari
1   From the Departamento de Hemostasia y Trombosis, Instituto de Investigaciones Hematológicas “Mariano R. Castex”, Academia Nacional de Medicina, Buenos Aires, Argentina
› Author AffiliationsThis work was partially supported by Fundaciόn “Alberto J. Roemmers” and by Fundaciόn “René Baron”, Buenos Aires, Argentina.
Further Information

Publication History

Received 02 February 2000

Accepted after revision 29 February 2000

Publication Date:
10 December 2017 (online)

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  • References

  • 1 Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-8.
    CrossrefPubMedGoogle Scholar
  • 2 Bertina RM. Molecular risk factors for thrombosis. Thromb Haemost 1999; 82: 601-9.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Dahlbäck B. Activated protein C resistance and thrombosis: Molecular mechanisms of hypercoagulable state due to FVR506Q mutation. Semin Thromb Hemost 1999; 25: 273-89.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 de Visser MCH, Rosendaal FR, Bertina RM. A reduced sensitivity for activated protein C in the absence of factor V Leiden increases the risk of venous thrombosis. Blood 1999; 93: 1271-6.
    PubMedGoogle Scholar
  • 5 Kiechl S, Muigg A, Santer P, Mitterer M, Egger G, Oberhollenzer M, Oberhollenzer F, Mayr A, Gasperi A, Poewe W, Willeit J. Poor response to activated protein C as a prominent risk predictor of advanced atherosclerosis and arterial disease. Circulation 1999; 99: 614-9.
    CrossrefPubMedGoogle Scholar
  • 6 Jorquera JI, Montoro JM, Fernández MA, Aznar JA, Aznar J. Modified test for activated protein C resistance. Lancet 1994; 344: 1162-3.
    PubMedGoogle Scholar