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Semin Thromb Hemost 2016; 42(07): 789-797
DOI: 10.1055/s-0036-1592304
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Direct Oral Anticoagulants and Women

Hannah Cohen
1   Haemostasis Research Unit, Department of Haematology, University College London, London, United Kingdom
2   Department of Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom
,
Deepa R. J. Arachchillage
3   Department of Haematology, Imperial College Healthcare NHS Trust, London, United Kingdom
4   Department of Haematology, Imperial College London, London, United Kingdom
,
Jan Beyer-Westendorf
5   Center for Vascular Medicine and Department of Medicine III, University Hospital “Carl Gustav Carus,” Technische Universität Dresden, Germany
,
Saskia Middeldorp
6   Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Holland
,
Rezan A. Kadir
7   Katharine Dormandy Haemophilia Center and Thrombosis Unit, The Royal Free Hospital NHS Foundation Trust, London, United Kingdom
8   Department of Obstetrics and Gynaecology, The Royal Free Hospital NHS Foundation Trust, London, United Kingdom
› Author Affiliations
Further Information

Publication History

Publication Date:
05 October 2016 (online)

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Abstract

Direct oral anticoagulants (DOACs) provide an effective, safe, and convenient therapeutic alternative to warfarin and other vitamin K antagonists (VKAs), and are now established for a wide range of indications. The use of DOACs in women merits special consideration due to two main situations: first, in relation to fertility, pregnancy, and lactation in women of reproductive age; second, because of their bleeding risk, leading to abnormal uterine and/or other genital tract bleeding. This review focuses on these two clinical situations, including approaches to management in the context of available information.

Keywords

direct oral anticoagulants - fertility - pregnancy - lactation - abnormal uterine bleeding - heavy menstrual bleeding
 

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