Semin Reprod Med 2011; 29(5): 446-458
DOI: 10.1055/s-0031-1287668
© Thieme Medical Publishers

Management of Abnormal Uterine Bleeding in Low- and High-Resource Settings: Consideration of Cultural Issues

Rohana Haththotuwa1 , Malik Goonewardene2 , Shyam Desai3 , Lakshman Senanayake4 , Jaydeep Tank5 , Ian S. Fraser6
  • 1Ninewells CARE Mother and Baby Hospital, Colombo, Sri Lanka
  • 2Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka
  • 3Department of Obstetrics and Gynaecology, Mothercare Nursing Home, Mumbai University
  • 4UNFPA Sri Lanka, Colombo, Sri Lanka
  • 5Assisted Reproduction and In Vitro Fertilization (IVF), Center for Advanced Endoscopy, Ashwini Maternity and Surgical Hospital, Mumbai, India
  • 6Department of Obstetrics and Gynaecology, University of Sydney, Camperdown, Australia
Further Information

Publication History

Publication Date:
07 November 2011 (online)

ABSTRACT

In non industrialized countries the incidence of heavy menstrual bleeding (HMB) appears to be similar to that of industrialized countries, although data is scanty. In low-resource settings, women with abnormal uterine bleeding (AUB) often delay seeking medical care because of cultural beliefs that a heavy red menstrual bleed is healthy. Efforts to modify cultural issues are being considered. A detailed history and a meticulous examination are the important foundations of a definitive diagnosis and management in low-resource settings but are subject to time constraints and skill levels of the small numbers of health professionals. Women's subjective assessment of blood loss should be combined, if possible, with a colorimetric hemoglobin assessment, if full blood count is not possible. Outpatient endometrial sampling, transvaginal sonography, and hysteroscopy are available in some non industrialized countries but not in the lowest resource settings. After exclusion of serious underlying pathology, hematinics should be commenced and antifibrinolytic or nonsteroidal anti-inflammatory drugs considered during menses to control the bleeding. Intrauterine or oral progestogens or the combined oral contraceptive are often the most cost-effective long-term medical treatments. When medical treatment is inappropriate or has failed, the surgical options available most often are myomectomy or hysterectomy. Hysteroscopic endometrial resection or newer endometrial ablation procedures are available in some centers. If hysterectomy is indicated the vaginal route is the most appropriate in most low-resource settings. In low-resource settings, lack of resources of all types can lead to empirical treatments or reliance on the unproven therapies of traditional healers. The shortage of human resources is often compounded by a limited availability of operative time. Governments and specialist medical organizations have rarely included attention to AUB and HMB in their health programs. Local guidelines and attention to training of doctors, midwives, and traditional health workers are critical for prevention and improvement in management of HMB and its consequences for iron deficiency anemia and postpartum hemorrhage, the major killer of young women in developing countries.

REFERENCES

  • 1 Gao J, Ma LY, Zeng S, Fan HM, Han LH. Menstrual blood loss in healthy Chinese women.  Contraception. 1981;  23 (6) 591-601
  • 2 The Holy Bible. Leviticus 15:19, and 24. 
  • 3 Omeora OU, Egwuatu VE. Menstruation in rural Igbo women of South East Nigeria: attitudes, beliefs and practices.  Afr J Reprod Health. 2008;  12 (1) 109-115
  • 4 Garg S, Sharma N, Sahay R. Socio-cultural aspects of menstruation in an urban slum in Delhi, India.  Reprod Health Matters. 2001;  9 (17) 16-25
  • 5 Walraven G, Ekpo G, Coleman R, Scherf C, Morison L, Harlow SD. Menstrual disorders in rural Gambia.  Stud Fam Plann. 2002;  33 (3) 261-268
  • 6 Joshi BN, Chauhan SL, Donde UM, Tryambake VH, Gaikwad NS, Bhadoria V. Reproductive health problems and help seeking behavior among adolescents in urban India.  Indian J Pediatr. 2006;  73 (6) 509-513
  • 7 Dutta S, Ray S. Menstrual health problems and hygienic practices among the adolescent girls of rural and peri-urban areas of West Bengal.  J Fam Welf. 2006;  52 73-85
  • 8 Wasserheit JN, Harris JR, Chakraborty J, Kay BA, Mason KJ. Reproductive tract infections in a family planning population in rural Bangladesh.  Stud Fam Plann. 1989;  20 (2) 69-80
  • 9 Khanna A, Goyal RS, Bhawsar R. Menstrual practices and reproductive problems: a study of adolescent girls in Rajasthan.  J Health Manag. 2005;  7 91-107
  • 10 Sanyal S, Ray S. Variation in the menstrual characteristics in adolescents of West Bengal.  Singapore Med J. 2008;  49 (7) 542-550
  • 11 Morrison J, Patel ST, Watson W, Zaidi QR, Mangione A, Goss TF. Assessment of the prevalence and impact of anemia on women hospitalized for gynecologic conditions associated with heavy uterine bleeding.  J Reprod Med. 2008;  53 (5) 323-330
  • 12 Duckitt K, Collins S. Menorrhagia. Clin Evid (Online) 2008;Sep 18:ii.  Available at: http://www.ncbi.nim.nih.gov/pubmed/19445802 Accessed August 17, 2010; 
  • 13 Harvey LJ, Armah CN, Dainty JR et al.. Impact of menstrual blood loss and diet on iron deficiency among women in the UK.  Br J Nutr. 2005;  94 (4) 557-564
  • 14 Chapple A. Iron deficiency anaemia in women of South Asian descent: a qualitative study.  Ethn Health. 1998;  3 (3) 199-212
  • 15 Chapple A, Ling M, May C. General practitioners' perceptions of the illness behaviour and health needs of South Asian women with menorrhagia.  Ethn Health. 1998;  3 (1-2) 81-93
  • 16 Kavle JA, Stoltzfus RJ, Witter F, Tielsch JM, Khalfan SS, Caulfield LE. Association between anaemia during pregnancy and blood loss at and after delivery among women with vaginal births in Pemba Island, Zanzibar, Tanzania.  J Health Popul Nutr. 2008;  26 (2) 232-240
  • 17 de Souza SS, Camargos AF, Ferreira MC et al.. Hemoglobin levels predict quality of life in women with heavy menstrual bleeding.  Arch Gynecol Obstet. 2010;  281 (5) 895-900
  • 18 Liu Z, Doan QV, Blumenthal P, Dubois RW. A systematic review evaluating health-related quality of life, work impairment, and health-care costs and utilization in abnormal uterine bleeding.  Value Health. 2007;  10 (3) 183-194
  • 19 AbouZahr C, Vaughan JP. Assessing the burden of sexual and reproductive ill-health: questions regarding the use of disability-adjusted life years.  Bull World Health Organ. 2000;  78 (5) 655-666
  • 20 Habiba M, Julian S, Taub N et al.. Limited role of multi-attribute utility scale and SF-36 in predicting management outcome of heavy menstrual bleeding.  Eur J Obstet Gynecol Reprod Biol. 2010;  148 (1) 81-85
  • 21 Matteson KA, Clark MA. Questioning our questions: do frequently asked questions adequately cover the aspects of women's lives most affected by abnormal uterine bleeding? Opinions of women with abnormal uterine bleeding participating in focus group discussions.  Women Health. 2010;  50 (2) 195-211
  • 22 Harlow SD, Campbell O MR. Menstrual dysfunction: a missed opportunity for improving reproductive health in developing countries.  Reprod Health Matters. 2000;  8 (15) 142-147
  • 23 Bernstein SJ, McGlynn EA, Siu AL Health Maintenance Organization Quality of Care Consortium et al. The appropriateness of hysterectomy. A comparison of care in seven health plans.  JAMA. 1993;  269 (18) 2398-2402
  • 24 Chapple A, Ling M, May C. Menorrhagia: the need for equity in treatment in Britain.  Reprod Health Matters. 1997;  5 (9) 132-138
  • 25 Wanjohi JK, Sekadde-kigondu CB, Maina FW, Mati JK. Menstrual blood loss (MBL) in nulliparous Kenyan women.  J Obstet Gynaecol East Cent Africa. 1983;  2 (1) 23-26
  • 26 Barr F, Brabin L, Agbaje S et al.. Reducing iron deficiency anemia due to heavy menstrual blood loss in Nigerian rural adolescents.  Public Health Nutr. 1998;  1 249-257
  • 27 Andrade A TL, Souza JP, Shaw Jr ST, Belsey EM, Rowe PJ. Menstrual blood loss and body iron stores in Brazilian women.  Contraception. 1991;  43 (3) 241-249
  • 28 Harlow SD, Campbell O MR. Epidemiology of menstrual disorders in developing countries: a systematic review.  BJOG. 2004;  111 (1) 6-16
  • 29 Gao J, Zeng S, Sun BL, Fan HM, Han LH. Menstrual blood loss and hematologic indices in healthy Chinese women.  J Reprod Med. 1987;  32 (11) 822-826
  • 30 Filippi V, Marshall T, Bulut A, Graham W, Yolsal N. Asking questions about women's reproductive health: validity and reliability of survey findings from Istanbul.  Trop Med Int Health. 1997;  2 (1) 47-56
  • 31 Brabin L, Barr F. Adolescent menstrual health complaints.  Afr Health. 1999;  1 12-13
  • 32 Khatri R, Gupta AN. Effect of childbirth on menstrual pattern.  Indian J Med Res. 1978;  67 66-72
  • 33 Barr F, Brabin L, Aqbaje O. A pictorial chart for managing common menstrual disorders in Nigerian adolescents.  Int J Gynecol Obstet. 1999;  66 (1) 51-53
  • 34 Chaturvedi SK, Chandra PS. Sociocultural aspects of menstrual attitudes and premenstrual experiences in India.  Soc Sci Med. 1991;  32 (3) 349-351
  • 35 McMaster J, Cormie K, Pitts M. Menstrual and premenstrual experiences of women in a developing country.  Health Care Women Int. 1997;  18 (6) 533-541
  • 36 Lu ZJ. The relationship between menstrual attitudes and menstrual symptoms among Taiwanese women.  J Adv Nurs. 2001;  33 (5) 621-628
  • 37 O'Flynn N. Menstrual symptoms: the importance of social factors in women's experiences.  Br J Gen Pract. 2006;  56 (533) 950-957
  • 38 Critchley J, Bates I. Haemoglobin colour scale for anaemia diagnosis where there is no laboratory: a systematic review.  Int J Epidemiol. 2005;  34 (6) 1425-1434
  • 39 Higham JM, O'Brien PM, Shaw RW. Assessment of menstrual blood loss using a pictorial chart.  Br J Obstet Gynaecol. 1990;  97 (8) 734-739
  • 40 World Health Organization . Asia Pacific Strategy for Strengthening Health Laboratory Service 2010–2015.  World Health Organization report. 2010;  ISBN 978 92 9061 429 6
  • 41 Hongoro C, McPake B. How to bridge the gap in human resources for health.  Lancet. 2004;  364 (9443) 1451-1456
  • 42 Ely JW, Kennedy CM, Clark EC, Bowdler NC. Abnormal uterine bleeding: a management algorithm.  J Am Board Fam Med. 2006;  19 (6) 590-602
  • 43 Inchahurraga S. The role of traditional healers: bridging the gap between the formal and the informal sector. Available at: http://healthdev.net/site/post.php?s=837 (Supported by International HIV/AIDS Alliance). Accessed August 31, 2010
  • 44 Carter M. Traditional healers could play key role in ART (anti-retroviral therapy) rollout, NAM aidsmap 1. December 2008. Available at: http://www.aidsmap.com/page/1432601/
  • 45 Makundi EA, Malebo HM, Mhame P, Kitua AY, Warsame M. Role of traditional healers in the management of severe malaria among children below five years of age: the case of Kilosa and Handeni Districts, Tanzania.  Malar J. 2006;  5 58-62
  • 46 Fikree FF, Bhatti LI, Khan A. Perceptions of Gynecological Morbidity in Women from Low Socioeconomic Settlements of Karachi, Pakistan: Final Report. Karachi, Pakistan: Aga Khan University; 2002
  • 47 Harlow SD, Campbell O MR. Menstrual dysfunction: a missed opportunity for improving reproductive health in developing countries.  Reprod Health Matters. 2000;  8 (15) 142-147
  • 48 Harlow SD, Campbell O MR. Epidemiology of menstrual disorders in developing countries: a systematic review.  BJOG. 2004;  111 (1) 6-16
  • 49 Osei J, Critchley H. Menorrhagia, mechanisms and targeted therapies.  Curr Opin Obstet Gynecol. 2005;  17 (4) 411-418
  • 50 Anker SD, Comin Colet J, Filippatos G et al. FAIR-HF Trial Investigators. Ferric carboxymaltose in patients with heart failure and iron deficiency.  N Engl J Med. 2009;  361 (25) 2436-2448
  • 51 Nelson AL, Teal SB. Medical therapies for chronic menorrhagia.  Obstet Gynecol Surv. 2007;  62 (4) 272-281
  • 52 Elder MG. Prostaglandins and menstrual disorders.  Br Med J (Clin Res Ed). 1983;  287 (6394) 703-704
  • 53 Munro MG. Abnormal uterine bleeding in the reproductive years. Part II-medical management.  J Am Assoc Gynecol Laparosc. 2000;  7 (1) 17-35
  • 54 National Health Committee. Guidelines for the Manage- ment of Heavy Menstrual Bleeding. Christchurch, New Zealand: National Health Committee; 1998
  • 55 Astedt B. Clinical pharmacology of tranexamic acid.  Scand J Gastroenterol Suppl. 1987;  137 22-25
  • 56 Edlund M, Andersson K, Rybo G, Lindoff C, Astedt B, von Schoultz B. Reduction of menstrual blood loss in women suffering from idiopathic menorrhagia with a novel anti- fibrinolytic drug (Kabi 2161).  Br J Obstet Gynaecol. 1995;  102 (11) 913-917
  • 57 Fraser IS. Treatment of ovulatory and anovulatory dysfunc- tional uterine bleeding with oral progestogens.  Aust N Z J Obstet Gynaecol. 1990;  30 (4) 353-356
  • 58 Irvine GA, Campbell-Brown MB, Lumsden MA, Heikkilä A, Walker JJ, Cameron IT. Randomised comparative trial of the levonorgestrel intrauterine system and norethisterone for treatment of idiopathic menorrhagia.  Br J Obstet Gynaecol. 1998;  105 (6) 592-598
  • 59 Kaunitz AM. Injectable depot medroxyprogesterone acetate contraception: an update for U.S. clinicians.  Int J Fertil Womens Med. 1998;  43 (2) 73-83
  • 60 Product monograph_Mirena. 5th ed. Finland: Schering AG and Leiras Oy; 2002
  • 61 National Collaborating Centre for Women's & Children's Health. Heavy Menstrual Bleeding, Clinical Guideline, London, UK: NICE; 2007
  • 62 Cameron IT. The levonorgestrel intrauterine system: the benefits of reduced bleeding.  Eur J Contracept Reprod Health Care. 2001;  6 (Suppl 1) 27-32
  • 63 Lethaby AE, Cooke I, Rees M. Progesterone or proges- togen-releasing intrauterine systems for heavy menstrual bleeding.  Cochrane Database Syst Rev. 2005;  (4) CD002126
  • 64 Mansour D. Modern management of abnormal uterine bleeding: the levonorgestrel intra-uterine system.  Best Pract Res Clin Obstet Gynaecol. 2007;  21 (6) 1007-1021
  • 65 Barrington JW, Arunkalaivanan AS, Abdel-Fattah M. Comparison between the levonorgestrel intrauterine system (LNG-IUS) and thermal balloon ablation in the treatment of menorrhagia.  Eur J Obstet Gynecol Reprod Biol. 2003;  108 (1) 72-74
  • 66 Busfield RA, Farquhar CM, Sowter MC et al.. A randomized trial comparing the levonorgestrel intra-uterine system and thermal balloon ablation for heavy menstrual bleeding.  Br J Obstet Gynaecol. 2006;  113 257-263
  • 67 Lähteenmäki P, Haukkamaa M, Puolakka J et al.. Open randomised study of use of levonorgestrel releasing intra- uterine system as alternative to hysterectomy.  BMJ. 1998;  316 (7138) 1122-1126
  • 68 Kingman CE, Kadir RA, Lee CA, Economides DL. The use of levonorgestrel-releasing intrauterine system for treatment of menorrhagia in women with inherited bleeding disorders.  BJOG. 2004;  111 (12) 1425-1428
  • 69 Lamb MP. Danazol in menorrhagia: a double blind placebo controlled trial.  J Obstet Gynaecol. 1987;  7 212-216
  • 70 Beaumont H, Augood C, Duckitt K, Lethaby A. Danazol for heavy menstrual bleeding.  Cochrane Database Syst Rev. 2002;  (2) CD001017
  • 71 Duleba AJ, Heppard MC, Soderstrom RM, Townsend DE. A randomized study comparing endometrial cryoablation and rollerball electroablation for treatment of dysfunctional uterine bleeding.  J Am Assoc Gynecol Laparosc. 2003;  10 (1) 17-26
  • 72 Lethaby A, Hickey M, Garry R. Endometrial destruction techniques for heavy menstrual bleeding.  Cochrane Data- base Syst Rev. 2005;  (4) CD001501
  • 73 Dores GB, Richart RM, Nicolau SM et al.. Evaluation of Hydro-Ablator for endometrial destruction in patients with menorrhagia.  J Am Assoc Gynecol Laparosc. 1999;  6 265-268
  • 74 Bhattacharya S, Cameron IM, Parkin DE et al.. A pragmatic randomised comparison of transcervical resection of the endometrium with endometrial laser ablation for the treatment of menorrhagia.  Br J Obstet Gynaecol. 1997;  104 (5) 601-607
  • 75 Wamsteker K, Emanuel MH, de Kruif JH. Transcervical hysteroscopic resection of submucous fibroids for abnormal uterine bleeding: results regarding the degree of intramural extension.  Obstet Gynecol. 1993;  82 (5) 736-740
  • 76 Sculpher M, Thompson E, Brown J, Garry R. A cost-effective analysis of goserelin compared with danazol as endometrial thinning agents.  Br J Obstet Gynaecol. 2000;  107 340-346
  • 77 Lethaby A, Vollenhoven B, Sowter M. Pre-operative GnRH analogue therapy before hysterectomy or myomec- tomy for uterine fibroids.  Cochrane Database Syst Rev. 2000;  (2) CD000547-
  • 78 Duggal BS, Wadhwa RD, Narayan S, Tarneja P, Chato- padhava AB. Transcervical resection of endometrium-will it edge out hysterectomy?.  Med J Armed Forces India. 2003;  59 202-204
  • 79 Overton C, Hargreaves J, Maresh M. A national survey of the complications of endometrial destruction for menstrual disorders: the MISTLETOE study. Minimally Invasive Surgical Techniques-Laser, EndoThermal or Endoresce- tion.  Br J Obstet Gynaecol. 1997;  104 (12) 1351-1359
  • 80 Indman PD, Brooks PG, Cooper JM, Loffer FD, Valle RF, Vancaillie TG. Complications of fluid overload from resectoscopic surgery.  J Am Assoc Gynecol Laparosc. 1998;  5 (1) 63-67
  • 81 Parker RB, Thagana NG. Hysteroscopic surgery at the Aga Khan Hospital, Nairobi.  E Afr Med J. 2004;  81 336-340
  • 82 Chacko N, Seshadri L, Ninan S. Transcervical endometrial resection when hysterectomy is dangerous.  Natl Med J India. 1995;  8 (2) 63-64
  • 83 Gnanaraj J, Lionel J. Endometrial resection/vaporization: a patient-friendly first option treatment for menorrhagia in rural areas.  Available at: http://td.rsmjournals.com/cgi/content/abstract/38/2/103 Accessed August 23, 2010; 
  • 84 Cooper JM, Erickson ML. Global endometrial ablation technologies.  Obstet Gynecol Clin North Am. 2000;  27 (2) 385-396 viii
  • 85 Garside R, Stein K, Wyatt K, Round A, Pitt M. A cost- utility analysis of microwave and thermal balloon endome- trial ablation techniques for the treatment of heavy menstrual bleeding.  BJOG. 2004;  111 (10) 1103-1114
  • 86 Donnez J, Polet R, Squifflet J et al.. Endometrial laser intrauterine thermo-therapy (ELITT): a revolutionary new approach to the elimination of menorrhagia.  Curr Opin Obstet Gynecol. 1999;  11 (4) 363-370
  • 87 Bongers MY. Second-generation endometrial ablation treatment: NovaSure.  Best Pract Res Clin Obstet Gynaecol. 2007;  21 (6) 989-994
  • 88 Abbott JA, Garry R. The surgical management of menorrhagia.  Hum Reprod Update. 2002;  8 (1) 68-78
  • 89 Miller CE. Myomectomy. Comparison of open and laparoscopic techniques.  Obstet Gynecol Clin North Am. 2000;  27 (2) 407-420
  • 90 Maresh MJ, Metcalfe MA, McPherson K et al.. The VALUE national hysterectomy study: description of the patients and their surgery.  Br J Obstet Gynaecol. 2002;  109 302-312
  • 91 Garry R, Fountain J, Mason S et al.. The eVALuate study: two parallel randomised trials, one comparing laparoscopic with abdominal hysterectomy, the other comparing laparo- scopic with vaginal hysterectomy.  BMJ. 2004;  328 (7432) 129-135
  • 92 Stringer NH, Walker JC, Meyer PM. Comparison of 49 laparoscopic myomectomies with 49 open myomectomies.  J Am Assoc Gynecol Laparosc. 1997;  4 (4) 457-464
  • 93 Goldfarb HA. Myoma coagulation (myolysis).  Obstet Gynecol Clin North Am. 2000;  27 (2) 421-430
  • 94 Hutchins Jr FL, Worthington-Kirsch R. Embolotherapy for myoma-induced menorrhagia.  Obstet Gynecol Clin North Am. 2000;  27 (2) 397-405 viii
  • 95 Clarke J. Editorial. Treatment of heavy menstrual bleeding: Patients prefer hysterectomy, but less radical treatment should be considered initially.  BMJ. 2010;  341 3771-
  • 96 You J HS, Sahota DS, MoYuen P. A cost-utility analysis of hysterectomy, endometrial resection and ablation and medical therapy for menorrhagia.  Hum Reprod. 2006;  21 (7) 1878-1883
  • 97 Lenihan Jr JP, Kovanda C, Cammarano C. Comparison of laparoscopic-assisted vaginal hysterectomy with tradi- tional hysterectomy for cost-effectiveness to employers.  Am J Obstet Gynecol. 2004;  190 (6) 1714-1720 discussion 1720-1722
  • 98 Crawford BL. Laparoscopic hysterectomy is not cost- effective compared with vaginal hysterectomy. Evidence based health care: a scientific approach to health policy 2004; 8.  Available at: http://linkinghub.elsevier.com/retrieve/pii/S1462941004000944 Accessed August 25, 2010; 
  • 99 Sculpher M, Manca A, Abbott J, Fountain J, Mason S, Garry R. Cost effectiveness analysis of laparoscopic hysterectomy compared with standard hysterectomy: results from a randomised trial.  BMJ. 2004;  328 (7432) 134-137
  • 100 Myomectomy abroad. Available at: http://www.medicaltourismco.com/myomectomy.surgery.abroad.php Accessed August 25, 2010
  • 101 Hysterectomy abroad. Available at: http://www.medicaltourismco.com/.../hysterectomy-surgery-abroad.php Accessed. August 25, 2010
  • 102 Farquhar CM, Steiner CA. Hysterectomy rates in the United States 1990–1997.  Obstet Gynecol. 2002;  99 (2) 229-234
  • 103 Sheth SS. Vaginal hysterectomy.  Best Pract Res Clin Obstet Gynaecol. 2005;  19 (3) 307-332
  • 104 Kovac SR. Decision-directed hysterectomy: a possible approach to improve medical and economic outcomes.  Int J Gynaecol Obstet. 2000;  71 (2) 159-169
  • 105 Hidlebaugh DA. Cost and quality-of-life issues associated with different surgical therapies for the treatment of abnormal uterine bleeding.  Obstet Gynecol Clin North Am. 2000;  27 (2) 451-465
  • 106 Levy BS, Luciano DE, Emery LL. Outpatient vaginal hysterectomy is safe for patients and reduces institutional cost.  J Minim Invasive Gynecol. 2005;  12 (6) 494-501
  • 107 Doucette RC, Sharp HT, Alder SC. Challenging generally accepted contraindications to vaginal hysterectomy.  Am J Obstet Gynecol. 2001;  184 (7) 1386-1389 discussion 1390-1391
  • 108 American College of Obstetricians and Gynecologists. ACOG Committee Opinion No. 444: choosing the route of hysterectomy for benign disease.  Obstet Gynecol. 2009;  114 (5) 1156-1158
  • 109 Carlson KJ, Miller BA, Fowler Jr FJ. The Maine Women's Health Study: I. Outcomes of hysterectomy.  Obstet Gynecol. 1994;  83 (4) 556-565
  • 110 El-Toukhy TA, Hefni M, Davies A, Mahadevan S. The effect of different types of hysterectomy on urinary and sexual functions: a prospective study.  J Obstet Gynaecol. 2004;  24 (4) 420-425
  • 111 Shava J, Nene NL, Mpande L. Vaginal hysterectomy. A five year prospective descriptive study.  Cent Afr J Med. 2004;  50 (7-8) 61-65
  • 112 Tebeu PM, Fomulu JN, Nana Njotang P et al.. Effectiveness of vaginal hysterectomy for benign conditions in semi-urban hospital: report from Maroua-Cameroon.  Trop Doct. 2009;  39 (4) 200-205
  • 113 Reid PC, Mukri F. Trends in number of hysterectomies performed in England for menorrhagia: examination of health episode statistics, 1989 to 2002–3.  BMJ. 2005;  330 (7497) 938-939

Rohana HaththotuwaM.B.B.S. (SL) 

Ninewells CARE Mother & Baby Hospital

55/1, Kirimandala Mawatha, Colombo 5, Sri Lanka

Email: rohana@ninewellscare.com

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