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Geburtshilfe Frauenheilkd 2011; 71(11): 939-953
DOI: 10.1055/s-0031-1280313
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Mammakarzinom 2011 – Neue Aspekte

Breast Cancer 2011 – New AspectsS. Kümmel1 , H. C. Kolberg2 , D. Lüftner3 , M. P. Lux4 , N. Maass5 , F. Schütz6 , P. A. Fasching4 , 7 , T. Fehm8 , W. Janni9
  • 1Klinik für Senologie, Kliniken Essen-Mitte
  • 2Klinik für Gynäkologie und Geburtshilfe, Marienhospital Bottrop
  • 3Medizinische Klinik und Poliklinik II, Campus Charité Mitte, Berlin
  • 4Frauenklinik des Universitätsklinikums Erlangen
  • 5Frauenklinik des Universitätsklinikums Aachen
  • 6Frauenklinik des Universitätsklinikums Heidelberg
  • 7University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, CA, USA
  • 8Universitäts-Frauenklinik Tübingen
  • 9Frauenklinik des Universitätsklinikums Düsseldorf
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Publication History

eingereicht 28.9.2011

akzeptiert 24.10.2011

Publication Date:
23 November 2011 (online)

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Zusammenfassung

Die Behandlungsoptionen und ebenfalls die Charakteristika zur Therapieentscheidung der Patientin mit einem primären und fortgeschrittenen Mammakarzinom werden immer vielfältiger. Neue zielgerichtete Therapien in Kombination mit etablierten Chemotherapien erweitern das Spektrum, doch potenziell vielversprechende Kombinationen erzielen nicht immer ein besseres Ergebnis. Neuste Daten aus der Pharmakogenomik weisen auf Prognose- und Prädiktivfaktoren hin, die nicht nur die Eigenschaften des Tumors, sondern außerdem die vererbbaren genetischen Eigenschaften der Patientin berücksichtigen. Die aktuelle Therapieentscheidung ist somit mittlerweile eine Kombination aus klassischerweise klinischen und modernen molekularen Biomarkern. Immer häufiger werden zusätzlich gesundheitsökonomische Aspekte berücksichtigt, sodass außerdem gesundheitspolitische Überlegungen eine Rolle spielen können. Diese Übersichtsarbeit baut auf den aktuellen Kongressen auf, die jedes Jahr stattfinden. Der letzte berücksichtigte ist hierbei die Jahrestagung der American Society of Clinical Oncology (ASCO) 2011 in Chicago.

Abstract

The treatment options for primary and metastatic breast cancer patients as well as the characteristics considered for therapy decision continue to become more diverse. New target therapies in combination with established chemotherapy regimens extend the range, however, potentially promising combinations do not always result in a benefit for the patient. Latest pharmacogenomics results hint towards prognosis and predictive factors, which do not only focus on the individual properties of the tumor, they also consider the hereditary genetics of the patient. As a result, state of the art therapy decision includes classical clinical as well as modern molecular biomarkers, however, pharmacoeconomic aspects continue to increase in importance in physicians' treatment algorithms. This review builds on the recent congresses, which present new data on the treatment of breast cancer. The last included one is the Annual Meeting of the American Society of Clinical Oncology (ASCO) 2011.

Schlüsselwörter

Mammakarzinom - Therapie - Prognose - molekulare Marker - Studien

Key words

breast cancer - therapy - prognosis - molecular marker - studies

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S. Kümmel

Kliniken Essen-Mitte
Evang. Huyssens-Stiftung/Knappschaft GmbH

Henricistraße 92

45136 Essen

Email: s.kuemmel@kliniken-essen-mitte.de

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