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Exp Clin Endocrinol Diabetes 1990; 96(4): 117-120
DOI: 10.1055/s-0029-1210998
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Estradiol Benzoate Decreases the Blood Flow through the Tibia of Female Rats

J. Kapitola, J. Kubíčková
  • Laboratory for Endocrinology and Metabolism and 3rd Medical Department (Head: Academician V. Pacovský), Charles University, Prague/Czechoslovakia
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Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

Effect of estradiol benzoate (EB, Agofollin Depot Spofa, CSSR, 1 mg s.c. once a week for 4 weeks) on local blood flow through the tibia of intact and oophorectomized (00X) female rats was studied using the 85Sr-microsphere method. In experiment A, the 85Sr-microsphere uptake and blood flow was increased 4 weeks after 00X and significantly decreased after EB in both the intact and OOX animals. In experiment B (intact female rats), the decrease after EB was confirmed both in microsphere uptake and tibial blood flow (48.8% and 57.1% respectively). No changes in the cardiac output and the marked fall of the uptake of labelled microspheres suggest a local circulatory reaction.

Key words

Bone blood flow - Estradiol benzoate - Rat

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