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Exp Clin Endocrinol Diabetes 1990; 96(4): 91-95
DOI: 10.1055/s-0029-1210993
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Effect of Intracerebroventricular Insulin on the Hypothalamic and Neurohypophysial Oxytocin Activity in Euhydrated or Dehydrated Rats

Božena Stempniak, J. W. Guzek
  • Department of Pathophysiology (Head: Prof. Dr. J. W. Guzek) University School of Medicine, Łódź/Poland
Further Information

Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

Rats dehydrated up to four days were given intracerebroventricularly insulin in a daily dose of 100 ng. Insulin decreased significantly the hypothalamic and neurohypophysial oxytocin content in euhydrated rats. In dehydrated animals the oxytocin activity in the hypothalamo-neurohypophysial system, markedly depleted after deprivation of water, could be further reduced by intracerebroventricular treatment with insulin.

These results seem to suggest a possible regulatory role of brain insulin in the mechanisms of oxytocin release.

Key words

Insulin - Oxytocin - Hypothalamus - Neurohypophysis

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