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Gepubliceerd in: Journal of Abnormal Child Psychology 4/2012

01-05-2012

Processing Speed and Neurodevelopment in Adolescent-Onset Psychosis: Cognitive Slowing Predicts Social Function

Auteurs: Peter Bachman, Tara A. Niendam, Maria Jalbrzikowkski, Chan Y. Park, Melita Daley, Tyrone D. Cannon, Carrie E. Bearden

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 4/2012

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Abstract

Onset of psychosis may be associated with abnormal adolescent neurodevelopment. Here we examined the neurocognitive profile of first-episode, adolescent onset psychosis (AOP) as compared to typically developing adolescents, and asked whether neurocognitive performance varied differentially as a function of age in the cases compared with controls. A comprehensive neuropsychological battery was administered to 35 patients experiencing a first-episode of a DSM-IV psychotic disorder and to 31 matched controls. Clinicians also rated subjects’ social and role functioning, both at the time of neuropsychological assessment and 1 year later. Although patients displayed a wide range of impairments relative to controls, their most pronounced deficits included verbal memory, sensorimotor dexterity and cognitive processing speed. Among these, only processing speed showed a significant group-by-age interaction, consistent with an aberrant developmental course among AOP patients. Processing speed also accounted for substantial variance in other areas of deficit, and predicted social functioning 1 year later. AOP patients fail to show normal age-related increases in processing speed, which in turn predicts poorer functional outcomes. This pattern is consistent with the view that adolescent brain developmental processes, such as myelination, may be disrupted in these patients.
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Metagegevens
Titel
Processing Speed and Neurodevelopment in Adolescent-Onset Psychosis: Cognitive Slowing Predicts Social Function
Auteurs
Peter Bachman
Tara A. Niendam
Maria Jalbrzikowkski
Chan Y. Park
Melita Daley
Tyrone D. Cannon
Carrie E. Bearden
Publicatiedatum
01-05-2012
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 4/2012
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-011-9592-5

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