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The use of psychotropics by categories and the reason for their prescription was investigated in a large scale study of 4,069 adults with ID, including those with autism spectrum disorder, in New York State. Similar to other studies it was found that 58 % (2,361/4,069) received one or more psychotropics. Six percent received typical, 6 % received typical, while 39 % received atypical antipsychotics. There was greater use of antidepressants (23 %), mood stabilizers (19 %), and antianxiety agents (16 %) relative to other studies. The use of anti-impulsives, stimulants and hypnotics was rare (1–2 %). Half of the psychotropics were prescribed for treatment of major psychiatric disorders, 13 % for control of challenging behaviors, and 38 % for both. Results indicated that the major psychiatric disorders, except anxiety disorder and autism, influenced the use of psychotropics and the number of medication used. These findings imply that although practitioners still rely too heavily on the use of antipsychotics in this population, there is a welcome shift in the prescription patterns relative to other studies. The practitioners appeared to use psychotropics primarily to treat diagnosed psychiatric disorders and not just to control aggressive behavior which suggests that evidence-based practice of psychiatry is playing an increasing role in the ID population.
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Aman, M., Buitelaar, J., Smedt, G. D., Wapenaar, R., & Binder, C. (2005). Pharmacotherapy of disruptive behavior and item changes on a standardized rating scale: Pooled analysis of risperidone effects in children with subaverage IQ. Journal of Child and Adolescent Psychopharmacology, 15, 220–232. PubMedCrossRef
Aman, M. G., Burrow, W. H., & Wolford, P. L. (1995). The Aberrant Behavior Checklist-Community: Factor validity and effect of subject variables for adults in group homes. American Journal of Mental Retardation, 100, 283–292. PubMed
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders-IV. Washington, DC: American Psychiatric Association.
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders fourth edition text revision. Washington DC: American Psychiatric Association. CrossRef
Branford, D. (1994). A study of the prescribing for people with learning disabilities living in the community and in National Health Service care. Journal of Intellectual Disabilities Research, 38(Pt 6), 577–586.
Clarke, D. J., & Gomez, G. A. (1999). Utility of modified DCR-10 criteria in the diagnosis of depression associated with intellectual disability. Journal of Intellectual Disabilities Research, 43(Pt 5), 413–420.
Clarke, D. J., Kelley, S., Thinn, K., & Corbett, J. A. (1990). Psychotropic drugs and mental retardation: 1. Disabilities and the prescription of drugs for behaviour and for epilepsy in three residential settings. Journal of Mental Deficiency Research, 34(Pt 5), 385–395. PubMed
Cohen, I. L., Tsiouris, J. A., Flory, M. J., Kim, S.-Y., Freedland, R., Heaney, G., et al. (2010). A large scale study of the psychometric characteristics of the IBR Modified Overt Aggression Scale: Findings and evidence for increased self-destructive behaviors in adult females with Autism Spectrum Disorder. Journal of Autism and Developmental Disorder, 40, 599–609. CrossRef
Cooper, S. A., Melville, C. A., & Einfeld, S. L. (2003). Psychiatric diagnosis, intellectual disabilities and diagnostic criteria for psychiatric disorders for use with adults with learning disabilities/mental retardation (DC-LD). Journal of Intellectual Disabilities Research, 47(Suppl 1), 3–15. CrossRef
Cooper, S. A., Smiley, E., Allan, L. M., Jackson, A., Finlayson, J., Mantry, D., et al. (2009). Adults with intellectual disabilities: Prevalence, incidence and remission of self-injurious behaviour, and related factors. Journal of Intellectual Disabilities Research, 53, 200–216. CrossRef
Crocker, A. G., Mercier, C., Allaire, J. F., & Roy, M. E. (2007). Profiles and correlates of aggressive behaviour among adults with intellectual disabilities. Journal of Intellectual Disabilities Research, 51, 786–801. CrossRef
de Kuijper, G., Hoekstra, P., Visser, F., Scholte, F. A., Penning, C., & Evenhuis, H. (2010). Use of antipsychotic drugs in individuals with intellectual disability (ID) in the Netherlands: Prevalence and reasons for prescription. Journal of Intellectual Disabilities Research, 54, 659–667. CrossRef
Deb, S., & Fraser, W. (1994). The use of psychotropic medication in people with learning disability: Towards rational prescribing. Human Psychopharmacology, 9, 259–272. CrossRef
Deb, S., Kwok, H., Bertelli, M., Salvador-Carulla, L., Bradley, E., Torr, J., et al. (2009). International guide to prescribing psychotropic medication for the management of problem behaviours in adults with intellectual disabilities. World Psychiatry, 8, 181–186. PubMed
Deb, S., Sohanpal, S. K., Soni, R., Lenotre, L., & Unwin, G. (2007). The effectiveness of antipsychotic medication in the management of behaviour problems in adults with intellectual disabilities. Journal of Intellectual Disabilities Research, 51, 766–777. CrossRef
Duggan, L., & Brylewski, J. (1999). Effectiveness of antipsychotic medication in people with intellectual disability and schizophrenia: A systematic review. Journal of Intellectual Disabilities Research, 43(Pt 2), 94–104. CrossRef
Fleming, I., Caine, A., Ahmed, S., & Smith, S. (1996). Aspects of the use of psychoactive medication among people with intellectual disabilities who have been resettled from long-stay hospitals into dispersed housing. Journal of Applied Research in Intellectual Disabilities, 9, 194–205. CrossRef
Fletcher, R., Loschen, E., Stavrakaki, C., & First, M. (2007). Diagnostic Manual-Intellectual Disability (DM-ID): A textbook of diagnosis of mental disorders in persons with intellectual disability. Kingston, NY: NADD Press.
Gadow, K. D., & Kalachnik, J. (1981). Prevalence and pattern of drug treatment for behavior and seizure disorders of TMR students. American Journal of Mental Deficiency, 85, 588–595. PubMed
Greendyke, R. M., & Kanter, D. R. (1986). Therapeutic effects of pindolol on behavioral disturbances associated with organic brain disease: A double-blind study. Journal of Clinical Psychiatry, 47, 423–426. PubMed
Greendyke, R. M., Kanter, D. R., Schuster, D. B., Verstreate, S., & Wootton, J. (1986). Propranolol treatment of assaultive patients with organic brain disease. A double-blind crossover, placebo-controlled study. Journal of Nervous and Mental Deficiencies, 174, 290–294. CrossRef
Harper, D. C., & Wadsworth, J. S. (1993). Behavioral problems and medication utilization. Mental Retardation, 31, 97–103. PubMed
Hill, B. K., Balow, E. A., & Bruininks, R. H. (1985). A national study of prescribed drugs in institutions and community residential facilities for mentally retarded people. Psychopharmacology Bulletin, 21, 279–284. PubMed
Hurley, A. D. (2008). Depression in adults with intellectual disability: Symptoms and challenging behaviour. Journal of Intellectual Disabilities Research, 52, 905–916. CrossRef
Intagliata, J., & Rinck, C. (1985). Psychoactive drug use in public and community residential facilities for mentally retarded persons. Psychopharmacology Bulletin, 21, 268–278. PubMed
Jones, S., Cooper, S. A., Smiley, E., Allan, L., Williamson, A., & Morrison, J. (2008). Prevalence of, and factors associated with, problem behaviors in adults with intellectual disabilities. Journal of Nervous and Mental Deficiencies, 196, 678–686. CrossRef
Kiernan, C., Reeves, D., & Alborz, A. (1995). The use of anti-psychotic drugs with adults with learning disabilities and challenging behaviour. Journal of Intellectual Disability Research, 39, 263–274.
Long, J. S., & Freese, J. (2006). Regression models for categorical dependent variables using stata (2nd ed.). College Station, TX: Stata Press.
Mahan, S., Holloway, J., Bamburg, J. W., Hess, J. A., Fodstad, J. C., & Matson, J. L. (2010). An Examination of psychotropic medication side effects: Does taking a greater number of psychotropic medications from different classes affect presentation of side effects in adults with ID? Research in Developmental Disabilities, 31, 1561–1569. PubMedCrossRef
Molyneux, P., Emerson, E., & Caine, A. (1999). Prescription of psychotropic medication to people with intellectual disabilities in primary health-care settings. Journal of Applied Research in Intellectual Disabilities, 12, 46–57. CrossRef
Moss, S. C., Prosser, H., Costello, H., Simpson, N., & Patel, P. (1996). PAS-ADD checklist. Manchester: Hester Adrian Research Centre, University of Manchester.
Neece, C. L., Baker, B. L., Blacher, J., & Crnic, K. A. (2011). Attention-deficit/hyperactivity disorder among children with and without intellectual disability: An examination across time. Journal of Intellectual Disabilities Research, 55, 623–635. CrossRef
Paton, C., Flynn, A., Shingleton-Smith, A., McIntyre, S., Bhaumik, S., Rasmussen, J., et al. (2011). Nature and quality of antipsychotic prescribing practice in UK psychiatry of intellectual disability services. Journal of Intellectual Disabilities Research, 55, 665–674. CrossRef
R Development Core Team. (2011). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. http://www.R-project.org/.
Romeo, R., Knapp, M., Tyrer, P., Crawford, M., & Oliver-Africano, P. (2009). The treatment of challenging behaviour in intellectual disabilities: cost-effectiveness analysis. Journal of Intellectual Disabilities Research, 53, 633–643. CrossRef
Rosenberg, R. E., Mandell, D. S., Farmer, J. E., Law, J. K., Marvin, A. R., & Law, P. A. (2010). Psychotropic medication use among children with autism spectrum disorders enrolled in a national registry, 2007–2008. Journal of Autism and Developmental Disorder, 40, 342–351. CrossRef
Ruedrich, S. L., Grush, L., & Wilson, J. (1990). Beta adrenergic blocking medications for aggressive or self-injurious mentally retarded persons. American Journal of Mental Retardation, 95, 110–119. PubMed
Scheifes, A., Stolker, J. J., Egberts, A. C., Nijman, H. L., & Heerdink, E. R. (2011). Representation of people with intellectual disabilities in randomised controlled trials on antipsychotic treatment for behavioural problems. Journal of Intellectual Disabilities Research, 55, 650–664. CrossRef
Silva, D. A. (1979). The use of medication in a residential institution for mentally retarded persons. Mental Retardation, 17, 285–288. PubMed
Szalavitz, M. (2011, May 26). Drugging the vulnerable: Atypical antipsychotics in children and the elderly. Time:Heathland. Retrieved July 18, 2012 from http://healthland.time.com..
Tsiouris, J. A. (2010). Pharmacotherapy for aggressive behaviours in persons with intellectual disabilities: Treatment or mistreatment? Journal of Intellectual Disabilities Research, 54, 1–16. CrossRef
Tsiouris, J., Cohen, I. L., Patti, P. J., & Korosh, W. M. (2003). Treatment of previously undiagnosed psychiatric disorders in persons with developmental disabilities decreased or eliminated self-injurious behavior. Journal of Clinical Psychiatry, 62, 1081–1090. CrossRef
Tsiouris, J. A., Kim, S. Y., Brown, W. T., & Cohen, I. L. (2011). Association of aggressive behaviours with psychiatric disorders, age, sex and degree of intellectual disability: A large-scale survey. Journal of Intellectual Disabilities Research, 55, 636–649. CrossRef
Tyrer, P., Oliver-Africano, P., Ahmed, Z., Bouras, N., Cooray, S., Deb, S., et al. (2008). Risperidone, haloperidol, and placebo in the treatment of aggressive challenging behaviour in patients with intellectual disability: A randomised controlledtrial. Lancet, 371, 63.
Wilson, D. (2009). Poor children likelier to get antipsychotics. New York: New York Times.
World Health Organization. (1978). Mental disorders: Glossary and guide to their classification in accordance with the ninth revision of the international classification of diseases. Geneva: World Health Organization.
Wright, D. B., Strubler, K. A., & Vallano, J. P. (2011). Statistical techniques for juror and jury research. Legal and Criminological Psychology, 16, 90–125. CrossRef
Yudofsky, S. C., Silver, J. M., Jackson, W., Endicott, J., & Williams, D. (1986). The Overt Aggression Scale for the objective rating of verbal and physical aggression. American Journal of Psychiatry, 143, 35–39. PubMed
Zeiles, A. (2008). Regression models for count data in R. Journal of Statistical Software, 27, 8.
- Prevalence of Psychotropic Drug Use in Adults with Intellectual Disability: Positive and Negative Findings from a Large Scale Study
John A. Tsiouris
W. Ted Brown
Ira L. Cohen
- Springer US