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14-01-2019

Prevalence of mental health conditions and pain in adults with skeletal dysplasia

Auteurs: Sarah E. Jennings, Colleen P. Ditro, Michael B. Bober, William G. Mackenzie, Kenneth J. Rogers, Laura Conway, Angela L. Duker

Gepubliceerd in: Quality of Life Research | Uitgave 6/2019

Abstract

Purpose

We sought to examine the prevalence of depression and anxiety in adults with skeletal dysplasias, and to assess any correlations with pain.

Methods

Participation was via an anonymous REDCap survey, which consisted of sociodemographic questions followed by the brief pain inventory-short form (BPI-SF), patient health questionnaire-8 (PHQ-8), and generalized anxiety disorder-7 (GAD-7) questionnaires. These assessed pain, depression, and anxiety respectively.

Results

Of the 336 usable responses, 16.1% scored 10 or greater on the PHQ-8 consistent with current depression while 17.3% scored 10 or greater on the GAD-7 consistent with current anxiety. The majority of participants (76.2%) experienced pain, which was significantly associated with prior mental health diagnoses (p < 0.05). A total of 34% reported either a prior diagnosis of depression or scored 10 or greater on the PHQ-8, and 31% reported either a prior diagnosis of anxiety or scored 10 or greater on the GAD-7.

Conclusions

This study identified a substantial percentage of individuals with mental health concerns as well as pain in the adult skeletal dysplasia population. Further research is warranted to investigate barriers to service or treatment of mental health disorders as well as pain management.

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Bonafe, L., Cormier-Daire, V., Hall, C., Lachman, R., Mortier, G., Mundlos, S., et al. (2015). Nosology and classification of genetic skeletal disorders: 2015 edition. American Journal of Medical Genetics Part A, 167(12), 2869–2892.CrossRef

Alade, Y., Tunkel, D., Schulze, K., McGready, J., Jallo, G., Ain, M., et al. (2013). Cross-sectional assessment of pain and physical function in skeletal dysplasia patients. Clinical Genetics, 84(3), 237–243.CrossRefPubMed

Gamble, C., Nguyen, J., Hashmi, S. S., & Hecht, J. T. (2015). Pseudoachondroplasia and painful sequelae. American Journal of Medical Genetics Part A, 167(11), 2618–2622.CrossRef

Hunter, A. G., Bankier, A., Rogers, J. G., Sillence, D., & Scott, C. I. Jr. (1998). Medical complications of achondroplasia: A multicentre patient review. Journal of Medical Genetics, 35(9), 705–712.CrossRefPubMedPubMedCentral

Dhiman, N., Albaghdadi, A., Zogg, C. K., Sharma, M., Hoover-Fong, J. E., Ain, M. C., & Haider, A. H. (2017). Factors associated with health-related quality of life (HRQOL) in adults with short stature skeletal dysplasias. Quality of Life Research, 26(5), 1337–1348.CrossRefPubMed

Ain, M., Abdullah, M., Ting, B., Skolasky, R., Carlisle, E., Schkrohowsky, J., et al. (2010). Progression of low back and lower extremity pain in a cohort of patients with achondroplasia. Journal of Neurosurgery: Spine, 13(3), 335–340.PubMed

Unger, H., & Hecht, J. (2001). Pseudoachondroplasia and multiple epiphyseal dysplasia: New etiologic developments. American Journal of Medical Genetics, 106(4), 244–250.CrossRefPubMed

Terhal, P., Nievelstein, R., Verver, E., Topsakal, V., van Dommelen, P., Hoomaert, K., et al. (2015). A study of the clinical and radiological features in a cohort of 93 patients with a COL2A1 mutation causing spondyloepiphyseal dysplasia congenital or a related phenotype. American Journal of Medical Genetics Part A, 167(3), 461–475.CrossRef

Apajasalo, M., Sintonen, H., Rautonen, J., & Kaitila, I. (1998). Health-related quality of life of patients with genetic skeletal dysplasias. European Journal of Pediatrics, 157(2), 114–121.CrossRefPubMed

10.

Gollust, S. E., Thompson, R. E., Gooding, H. C., & Biesecker, B. B. (2003). Living with achondroplasia in an average-sized world: An assessment of quality of life. American Journal of Medical Genetics Part A, 120, 447–458.CrossRef

11.

Johansen, H., Andresen, I., Naess, E. E., & Hagen, K. B. (2007). Health status of adults with short stature: A comparison with the normal population and one well-known chronic disease (rheumatoid arthritis). Orphanet Journal of Rare Diseases, 2, 10.CrossRefPubMedPubMedCentral

12.

Vaara, P., Sintonen, H., Peltonen, J., Hokkanen, H., Poussa, M., & Ryoppy, S. (1999). Health-related quality of life in patients with diastrophic dysplasia. Scandinavian Journal of Public Health, 27(1), 38–42.CrossRefPubMed

13.

Mahomed, N., Spellmann, M., & Goldberg, M. (1998). Functional health status of adults with achondroplasia. American Journal of Medical Genetics, 78(1), 30–35.CrossRefPubMed

14.

Rodriguez-Gomez, J., Aldarondo, A., Vidot, F., Quinones, A., Rivera, M., Cintron, E., et al. (2015). Achondroplasia: A pilot study on the psychosocial and medical features of a sample in Puerto Rico. Boletin De La Asociacion Medica De Puerto Rico, 107(3), 58–65.PubMed

15.

Hunter, A. G. (1998). Some psychosocial aspects of nonlethal chondrodysplasias: II. Depression and anxiety. American Journal of Medical Genetics, 78(1), 9–12.CrossRefPubMed

16.

Bair, M. J., Wu, J., Damush, T. M., Sutherland, J. M., & Kroenke, K. (2008). Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients. Psychosomatic Medicine, 70(8), 890–897.CrossRefPubMedPubMedCentral

17.

Demyttenaere, K., Bruffaerts, R., Lee, S., Posada-Villa, J., Kovess, V., Angermeyer, M. C., et al. (2007). Mental disorders among persons with chronic back or neck pain: Results from the World Mental Health Surveys. Pain, 129(3), 332–342.CrossRefPubMed

18.

Gureje, O., Von Korff, M., Kola, L., Demyttenaere, K., He, Y., Posada-Villa, J., et al. (2008). The relation between multiple pains and mental disorders: results from the world mental health surveys. Pain, 135(1–2), 82–91.CrossRefPubMed

19.

Kroenke, K., Wu, J., Bair, M. J., Krebs, E. E., Damush, T. M., & Tu, W. (2011). Reciprocal relationship between pain and depression: A 12-month longitudinal analysis in primary care. The Journal of Pain, 12(9), 964–973.CrossRefPubMedPubMedCentral

20.

McWilliams, L. A., Cox, B. J., & Enns, M. W. (2003). Mood and anxiety disorders associated with chronic pain: An examination in a nationally representative sample. Pain, 106(1–2), 127–133.CrossRefPubMed

21.

Ohayon, M. M., & Schatzberg, A. F. (2009). Chronic pain and major depressive disorder in the general population. Journal of Psychiatric Research, 44(7), 454–461.CrossRef

22.

Robinson, R. L., Kroenke, K., Mease, P., Williams, D. A., Chen, Y., D’Souza, D., et al (2012). Burden of illness and treatment patterns for patients with fibromyalgia. Pain Medicine, 13(10), 1366–1376.CrossRefPubMed

23.

Sagheer, M. A., Khan, M. F., & Sharif, S. (2013). Association between chronic low back pain, anxiety and depression in patients at a tertiary care centre. Journal of the Pakistan Medical Association, 63(6), 688–690.PubMed

24.

Sharpe, L., McDonald, S., Correia, H., Raue, P., Meade, T., Nicholas, M., & Arean, P. (2017). Pain severity predicts depressive symptoms over and above illnesses and multimorbidity in older adults. BMC Psychiatry, 17(1), 166.CrossRefPubMedPubMedCentral

25.

Straub, L. E., & Cisternas, M. G. (2017). Psychological well-being among US adults with arthritis and the unmet need for mental health care. Open Access Rheumatology: Research and Reviews, 9, 101–110.CrossRef

26.

Kroenke, K., Spitzer, R. L., & Williams, J. B. (2001). The PHQ-9: Validity of a brief depression severity model. Journal of General Internal Medicine, 16(9), 606–613.CrossRefPubMedPubMedCentral

27.

Kroenke, K., & Spitzer, R. L. (2002). The PHQ-9: A new depression diagnostic and severity measure. Psychiatric Annals, 32(9), 509–515.CrossRef

28.

Kroenke, K., Strine, T. W., Spitzer, R. L., Williams, J. B., Berry, J. T., & Mokdad, A. H. (2009). The PHQ-8 as a measure of current depression in the general population. Journal of Affective Disorders, 114(1–3), 163–173.CrossRefPubMed

29.

Kroenke, K., Spitzer, R. L., Williams, J. B., & Lowe, B. (2010). The patient health questionnaire somatic, anxiety, and depressive symptom scales: A systematic review. General Hospital Psychiatry, 32(4), 345–359.CrossRefPubMed

30.

Spitzer, R., Kroenke, K., Williams, J., & Lowe, B. (2006). A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of Internal Medicine, 166(10), 1092–1097.CrossRefPubMed

31.

Naegeli, A. N., Tomaszewski, E. L., & Al Sawah, S. (2015). Psychometric validation of the brief pain inventory-short form in patients with systemic lupus erythematosus in the United States. Lupus, 24(13), 1377–1383.CrossRefPubMed

32.

Tan, G., Jensen, M. P., Thornby, J. I., & Shanti, B. F. (2004). Validation of the brief pain inventory for chronic nonmalignant pain. The Journal of Pain, 5(2), 133–137.CrossRefPubMed

33.

Williams, L. S., Jones, W. J., Shen, J., Robinson, R. L., Weinberger, M., & Kroenke, K. (2003). Prevalence and impact of depression and pain in neurology outpatients. Journal of Neurology, Neurosurgery, and Psychiatry, 74(11), 1587–1589.CrossRefPubMedPubMedCentral

34.

Siu, A. L., US Preventive Services Task Force (USPSTF), Bibbins-Domingo, K., Grossman, D. C., Baumann, L. C., Davidson, K. W., et al. (2016). Screening for depression in adults: US preventive services task force recommendation statement. Journal of the American Medical Association, 315(4), 380–387.CrossRefPubMed

Titel: Prevalence of mental health conditions and pain in adults with skeletal dysplasia
Auteurs: Sarah E. Jennings
Colleen P. Ditro
Michael B. Bober
William G. Mackenzie
Kenneth J. Rogers
Laura Conway
Angela L. Duker
Publicatiedatum: 14-01-2019
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 6/2019
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-019-02102-2

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