TODO: Skip to main content
Top
Gepubliceerd in:

09-07-2015

Pretreatment quality of life as a prognostic factor for early survival and functional outcomes in patients with head and neck cancer

Auteurs: Chan Joo Yang, Jong-Lyel Roh, Min-Ju Kim, Sang-wook Lee, Sung-Bae Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim

Gepubliceerd in: Quality of Life Research | Uitgave 1/2016

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Purpose

Quality of life (QOL) scores in cancer patients are associated with disease course and treatment outcomes. The aim of this study was to prospectively evaluate the associations between pretreatment QOL scores and survival or functional outcomes in patients with head and neck squamous cell carcinoma (HNSCC).

Methods

This prospective study enrolled a total of 141 patients with previously untreated HNSCC who underwent curative treatments from October 2010 to March 2012. Patients completed questionnaires on QOL including the European Organization of Research and Treatment of Cancer 30-item Core QOL questionnaire (EORTC QLQ-C30) and EORTC QOL questionnaire Head and Neck Cancer module (QLQ-H&N35). Univariate and multivariate analyses were used to identify QOL scores significantly associated with overall survival (OS), disease-free survival (DFS), and functional outcomes of gastrostomy or tracheostomy dependence.

Results

The 2-year OS and DFS rates were 82.3 and 78.0 %, respectively. The rates of gastrostomy and tracheostomy dependence were 9.2 and 14.9 %, respectively. After controlling for clinical factors, specific QOL indices of ‘dyspnea’ (hazard ratio 1.023 [95 % confidence interval 1.006–1.039]) and ‘appetite loss’ (1.020 [1.005–1.034]) were significantly associated with OS, while ‘insomnia’ (1.013 [1.002–1.025]) and ‘appetite loss’ (1.014 [1.001–1.026]) scores were significantly predictive of DFS (P < 0.05). Global health status score (0.967 [0.935–1.000]) and fatigue (1.048 [1.010–1.086]) were significantly associated with the dependence of tracheostomy (P < 0.05). There was no relationship between gastrostomy dependence and QOL indices.

Conclusion

This study provides evidence of significant relationships between certain pretreatment QOL measures and survival or functional outcomes in HNSCC patients.
Bijlagen
Deze inhoud is alleen zichtbaar als je bent ingelogd en de juiste rechten hebt.
Literatuur
Deze inhoud is alleen zichtbaar als je bent ingelogd en de juiste rechten hebt.
Metagegevens
Titel
Pretreatment quality of life as a prognostic factor for early survival and functional outcomes in patients with head and neck cancer
Auteurs
Chan Joo Yang
Jong-Lyel Roh
Min-Ju Kim
Sang-wook Lee
Sung-Bae Kim
Seung-Ho Choi
Soon Yuhl Nam
Sang Yoon Kim
Publicatiedatum
09-07-2015
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 1/2016
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-015-1063-y