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Gepubliceerd in: Research on Child and Adolescent Psychopathology 4/2023

22-11-2022

Prenatal Antidepressant Exposures and Autism Spectrum Disorder or Traits: A Retrospective, Multi-Cohort Study

Auteurs: Patricia A. Brennan, Anne L. Dunlop, Lisa A. Croen, Lyndsay A. Avalos, Amy L. Salisbury, Alison E. Hipwell, Sara S. Nozadi, Sheela Sathyanarayana, Rosa M. Crum, Rashelle Musci, Mingyi Li, Xiuhong Li, Maxwell Mansolf, Thomas G. O’Connor, Amy J. Elliott, Nidhi Ghildayal, Pi-I D. Lin, Jenna L.N. Sprowles, Joseph B. Stanford, Casper Bendixsen, Sally Ozonoff, Barry M. Lester, Coral L. Shuster, Kathi C. Huddleston, Jonathan Posner, Nigel Paneth

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 4/2023

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Abstract

Prenatal antidepressant exposure has been associated with increased risk for neurodevelopmental disorders in childhood, including autism spectrum disorder (ASD). The current study utilized multi-cohort data from the Environmental influences on Child Health Outcomes (ECHO) program (N = 3129) to test for this association, and determine whether the association remained after adjusting for maternal prenatal depression and other potential confounders. Antidepressants and a subset of selective serotonin reuptake inhibitors (SSRIs) were examined in relation to binary (e.g., diagnostic) and continuous measures of ASD and ASD related traits (e.g., social difficulties, behavior problems) in children 1.5 to 12 years of age. Child sex was tested as an effect modifier. While prenatal antidepressant exposure was associated with ASD related traits in univariate analyses, these associations were statistically non-significant in models that adjusted for prenatal maternal depression and other maternal and child characteristics. Sex assigned at birth was not an effect modifier for the prenatal antidepressant and child ASD relationship. Overall, we found no association between prenatal antidepressant exposures and ASD diagnoses or traits. Discontinuation of antidepressants in pregnancy does not appear to be warranted on the basis of increased risk for offspring ASD.
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Metagegevens
Titel
Prenatal Antidepressant Exposures and Autism Spectrum Disorder or Traits: A Retrospective, Multi-Cohort Study
Auteurs
Patricia A. Brennan
Anne L. Dunlop
Lisa A. Croen
Lyndsay A. Avalos
Amy L. Salisbury
Alison E. Hipwell
Sara S. Nozadi
Sheela Sathyanarayana
Rosa M. Crum
Rashelle Musci
Mingyi Li
Xiuhong Li
Maxwell Mansolf
Thomas G. O’Connor
Amy J. Elliott
Nidhi Ghildayal
Pi-I D. Lin
Jenna L.N. Sprowles
Joseph B. Stanford
Casper Bendixsen
Sally Ozonoff
Barry M. Lester
Coral L. Shuster
Kathi C. Huddleston
Jonathan Posner
Nigel Paneth
Publicatiedatum
22-11-2022
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 4/2023
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-022-01000-5

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