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Journal of Autism and Developmental Disorders

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06-02-2022 | Original Paper

Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort

Auteurs: Camilla V. B. Palm, Dorte Glintborg, Laura G. Find, Pia V. Larsen, Cilia M. Dalgaard, Henriette Boye, Tina K. Jensen, Anja F. Dreyer, Marianne S. Andersen, Niels Bilenberg

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2023

Abstract

Fetal androgen exposure may be associated with autism spectrum disorder (ASD). We studied 1777 mother–child pairs in the prospective Odense Child Cohort. Prenatal androgen exposure was assessed by maternal 3rd trimester testosterone concentrations, maternal polycystic ovary syndrome (PCOS), and 3 months offspring anogenital distance. ASD traits were assessed at age 3 years with the ASD-symptom scale of the Child Behavior Checklist for ages 1½–5 years. Maternal testosterone was positively associated with traits of ASD in boys (p < 0.05). Maternal PCOS was associated with increased offspring ASD traits (p = 0.046), but became non-significant after excluding parental psychiatric diagnosis. Offspring anogenital distance was not linked to ASD traits. Higher prevalence of ASD in boys could be linked to higher susceptibility to fetal androgen exposure.

vorige artikel The Development and Validation of a Subscale for the School-Age Child Behavior CheckList to Screen for Autism Spectrum Disorder

volgende artikel “Self-compassion changed my life”: The self-compassion experiences of autistic and non-autistic adults and its relationship with mental health and psychological wellbeing

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A. P. A. (2013). Diagnostic and statistical manual of mental disorders: DSM-5 (5th ed). American Psychiatric Association.

Atkinson, G., Campbell, D. J., Cawood, M. L., & Oakey, R. E. (1996). Steroids in human intrauterine fluids of early pregnancy. Clinical Endocrinology - Oxford, 44(4), 435–440. https://doi.org/10.1046/j.1365-2265.1996.710532.xCrossRefPubMed

Auyeung, B., Baron-Cohen, S., Ashwin, E., Knickmeyer, R., Taylor, K., & Hackett, G. (2009). Fetal testosterone and autistic traits. British Journal of Psychology, 100(Pt 1), 1–22. https://doi.org/10.1348/000712608x311731CrossRefPubMed

Auyeung, B., Taylor, K., Hackett, G., & Baron-Cohen, S. (2010). Foetal testosterone and autistic traits in 18 to 24-month-old children. Mol Autism, 1(1), 11. https://doi.org/10.1186/2040-2392-1-11CrossRefPubMedPubMedCentral

Bammann, B. L., Coulam, C. B., & Jiang, N. S. (1980). Total and free testosterone during pregnancy. American Journal of Obstetrics and Gynecology, 137(3), 293–298.CrossRefPubMed

Baron-Cohen, S. (2002). The extreme male brain theory of autism. Trends in Cognitive Sciences, 6(6), 248–254. https://doi.org/10.1016/s1364-6613(02)01904-6CrossRefPubMed

Baron-Cohen, S., Auyeung, B., Nørgaard-Pedersen, B., Hougaard, D. M., Abdallah, M. W., Melgaard, L., Cohen, A. S., Chakrabarti, B., Ruta, L., & Lombardo, M. V. (2015). Elevated fetal steroidogenic activity in autism. Molecular Psychiatry, 20(3), 369–376. https://doi.org/10.1038/mp.2014.48CrossRefPubMed

Baron-Cohen, S., Knickmeyer, R. C., & Belmonte, M. K. (2005). Sex differences in the brain: Implications for explaining autism. Science, 310(5749), 819–823. https://doi.org/10.1126/science.1115455CrossRefPubMed

Baron-Cohen, S., Lombardo, M. V., Auyeung, B., Ashwin, E., Chakrabarti, B., & Knickmeyer, R. (2011). Why are autism spectrum conditions more prevalent in males? PLoS Biology, 9(6), e1001081. https://doi.org/10.1371/journal.pbio.1001081CrossRefPubMedPubMedCentral

Cesta, C. E., Öberg, A. S., Ibrahimson, A., Yusuf, I., Larsson, H., Almqvist, C., D’Onofrio, Brian M., Bulik, Cynthia M., Fernández, Lorena, de la Cruz, David, & Mataix-Cols, MA Rosenqvist. (2020). Maternal polycystic ovary syndrome and risk of neuropsychiatric disorders in offspring: prenatal androgen exposure or genetic confounding? Psychological Medicine, 50(4), 616–624. https://doi.org/10.1017/s0033291719000424CrossRefPubMed

Cherskov, A., Pohl, A., Allison, C., Zhang, H., Payne, R. A., & Baron-Cohen, S. (2018). Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory. Translational Psychiatry, 8(1), 136. https://doi.org/10.1038/s41398-018-0186-7CrossRefPubMedPubMedCentral

Cheslack-Postava, K., Jokiranta, E., Suominen, A., Lehti, V., Sourander, A., & Brown, A. S. (2014). Variation by diagnostic subtype in risk for autism spectrum disorders associated with maternal parity among Finnish births. Paediatric and Perinatal Epidemiology, 28(1), 58–66. https://doi.org/10.1111/ppe.12094CrossRefPubMed

Conway, G., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Franks, S., Gambineri, A., Kelestimur, Fahrettin, Macut, Djuro, Micic, Dragan, Pasquali, Renato, Pfeifer, Marija, Pignatelli, Duarte, Michel Pugeat, B. O., & Yildiz. (2014). The polycystic ovary syndrome: A position statement from the European Society of Endocrinology. European Journal of Endocrinology, 171(4), P1-29. https://doi.org/10.1530/eje-14-0253CrossRefPubMed

Dean, A., & Sharpe, R. M. (2013). Clinical review: Anogenital distance or digit length ratio as measures of fetal androgen exposure: Relationship to male reproductive development and its disorders. Journal of Clinical Endocrinology and Metabolism, 98(6), 2230–2238. https://doi.org/10.1210/jc.2012-4057CrossRefPubMed

Duan, C., Pei, T., Li, Y., Cao, Q., Chen, H., & Fu, J. (2020). Androgen levels in the fetal cord blood of children born to women with polycystic ovary syndrome: A meta-analysis. Reproductive Biology and Endocrinology, 18(1), 81. https://doi.org/10.1186/s12958-020-00634-8CrossRefPubMedPubMedCentral

Filová, B., Ostatníková, D., Celec, P., & Hodosy, J. (2013). The effect of testosterone on the formation of brain structures. Cells, Tissues, Organs, 197(3), 169–177. https://doi.org/10.1159/000345567CrossRefPubMed

Finnbogadottir, S. K., Glintborg, D., Jensen, T. K., Kyhl, H. B., Nohr, E. A., & Andersen, M. (2017). Insulin resistance in pregnant women with and without polycystic ovary syndrome, and measures of body composition in offspring at birth and three years of age. Acta Obstetricia Et Gynecologica Scandinavica, 96(11), 1307–1314. https://doi.org/10.1111/aogs.13200CrossRefPubMed

Fombonne, E., MacFarlane, H., & Salem, A. C. (2021). Epidemiological surveys of ASD: Advances and remaining challenges. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-021-05005-9CrossRefPubMed

Geschwind, D. H. (2008). Autism: Many genes, common pathways? Cell, 135(3), 391–395. https://doi.org/10.1016/j.cell.2008.10.016CrossRefPubMedPubMedCentral

Glintborg, D., Hass Rubin, K., Nybo, M., Abrahamsen, B., & Andersen, M. (2015). Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome. European Journal of Endocrinology, 172(5), 627–638. https://doi.org/10.1530/eje-14-1108CrossRefPubMed

Glintborg, D., Jensen, R. C., Bentsen, K., Schmedes, A. V., Brandslund, I., Kyhl, H. B., Bilenberg, N., & Andersen, M. S. (2018). Testosterone levels in 3rd trimester in polycystic ovary syndrome. Odense Child Cohort. Journal of Molecular Medicine. https://doi.org/10.1210/jc.2018-00889CrossRef

Glintborg, D., Jensen, R. C., Schmedes, A. V., Brandslund, I., Kyhl, H. B., Jensen, T. K., & Andersen, M. S. (2019). Anogenital distance in children born of mothers with polycystic ovary syndrome: The Odense Child Cohort. Human Reproduction, 34(10), 2061–2070. https://doi.org/10.1093/humrep/dez122CrossRefPubMed

Idring, S., Magnusson, C., Lundberg, M., Ek, M., Rai, D., Svensson, A. C., Dalman, C., Karlsson, H., & Lee, B. K. (2014). Parental age and the risk of autism spectrum disorders: Findings from a Swedish population-based cohort. International Journal of Epidemiology, 43(1), 107–115. https://doi.org/10.1093/ije/dyt262CrossRefPubMed

James, W. H., & Grech, V. (2020). Is exposure to high levels of maternal intrauterine testosterone a causal factor common to male sex, autism, gender dysphoria, and non-right-handedness? Early Human Development, 141, 104872. https://doi.org/10.1016/j.earlhumdev.2019.104872CrossRefPubMed

Jensen, R. C., Jensen, D. M., Gibbons, K. S., Glintborg, D., Jensen, T. K., McIntyre, H. D., & Andersen, M. (2021). Adapting fasting plasma glucose threshold for GDM diagnosis according to the population distribution - An approach to the Danish paradox. Diabetes Research and Clinical Practice, 175, 108832. https://doi.org/10.1016/j.diabres.2021.108832CrossRefPubMed

Karlson, K., Breen, R., & Holm, A. (2013). Total, direct, and indirect effects in logit and probit models. Sociological Methods & Amp Research. https://doi.org/10.1177/0049124113494572CrossRef

Katsigianni, M., Karageorgiou, V., Lambrinoudaki, I., & Siristatidis, C. (2019). Maternal polycystic ovarian syndrome in autism spectrum disorder: A systematic review and meta-analysis. Molecular Psychiatry, 24(12), 1787–1797. https://doi.org/10.1038/s41380-019-0398-0CrossRefPubMed

Kelley, A. S., Puttabyatappa, M., Ciarelli, J. N., Zeng, L., Smith, Y. R., Lieberman, R., Pennathur, S., & Padmanabhan, V. (2019). Prenatal testosterone excess disrupts placental function in a sheep model of polycystic ovary syndrome. Endocrinology, 160(11), 2663–2672. https://doi.org/10.1210/en.2019-00386CrossRefPubMedPubMedCentral

Kosidou, K., Dalman, C., Widman, L., Arver, S., Lee, B. K., Magnusson, C., & Gardner, R. M. (2016). Maternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: A population-based nationwide study in Sweden. Molecular Psychiatry, 21(10), 1441–1448. https://doi.org/10.1038/mp.2015.183CrossRefPubMed

Kristensen, S., Henriksen, T. B., & Bilenberg, N. (2010). The Child Behavior Checklist for Ages 1.5–5 (CBCL/1(1/2)-5): assessment and analysis of parent- and caregiver-reported problems in a population-based sample of Danish preschool children. Nordic Journal of Psychiatry, 64(3), 203–209. https://doi.org/10.3109/08039480903456595CrossRefPubMed

Kung, K. T. F., Thankamony, A., Ong, K. K. L., Acerini, C. L., Dunger, D. B., Hughes, I. A., & Hines, M. (2021). No relationship between prenatal or early postnatal androgen exposure and autistic traits: Evidence using anogenital distance and penile length measurements at birth and 3 months of age. Journal of Child Psychology and Psychiatry, 62(7), 876–883. https://doi.org/10.1111/jcpp.13335CrossRefPubMed

Kyhl, H. B., Jensen, T. K., Barington, T., Buhl, S., Norberg, L. A., Jorgensen, J. S., Jensen, D. F., Christesen, H. T., Lamont, R. F., & Husby, S. (2015). The odense child cohort: Aims, design, and cohort profile. Paediatric and Perinatal Epidemiology, 29(3), 250–258. https://doi.org/10.1111/ppe.12183CrossRefPubMed

Larsson, M., Weiss, B., Janson, S., Sundell, J., & Bornehag, C. G. (2009). Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6–8 years of age. Neurotoxicology, 30(5), 822–831. https://doi.org/10.1016/j.neuro.2009.01.011CrossRefPubMedPubMedCentral

Levy, S. E., Rescorla, L. A., Chittams, J. L., Kral, T. J., Moody, E. J., Pandey, J., Pinto-Martin, Jennifer A., Pomykacz, Alison T., Ramirez, AnnJosette, Reyes, Nuri, Rosenberg, Cordelia Robinson, Schieve, Laura, Thompson, Aleda, Young, Lisa, Zhang, Jing, & Wiggins, L. (2019). ASD screening with the child behavior checklist/1.5–5 in the study to explore early development. Journal of Autism and Developmental Disorders, 49(6), 2348–2357. https://doi.org/10.1007/s10803-019-03895-4CrossRefPubMedPubMedCentral

Lord, C., Brugha, T. S., Charman, T., Cusack, J., Dumas, G., Frazier, T., Jones, Emily J. H., Jones, Rebecca M., Pickles, Andrew, State, Matthew W., Taylor, Julie Lounds, & Veenstra-VanderWeele, J. (2020). Autism spectrum disorder. Nature Reviews Disease Primers, 6(1), 5. https://doi.org/10.1038/s41572-019-0138-4CrossRefPubMedPubMedCentral

Lung, F. W., Chiang, T. L., Lin, S. J., Lee, M. C., & Shu, B. C. (2018). Advanced maternal age and maternal education disparity in children with autism spectrum disorder. Maternal and Child Health Journal, 22(7), 941–949. https://doi.org/10.1007/s10995-018-2470-9CrossRefPubMed

Maher, G. M., O’Keeffe, G. W., Dalman, C., Kearney, P. M., McCarthy, F. P., Kenny, L. C., & Khashan, A. S. (2020). Association between preeclampsia and autism spectrum disorder: A population-based study. Journal of Child Psychology and Psychiatry, 61(2), 131–139. https://doi.org/10.1111/jcpp.13127CrossRefPubMed

Makieva, S., Saunders, P. T., & Norman, J. E. (2014). Androgens in pregnancy: Roles in parturition. Human Reproduction Update, 20(4), 542–559. https://doi.org/10.1093/humupd/dmu008CrossRefPubMedPubMedCentral

Maliqueo, M., Lara, H. E., Sánchez, F., Echiburú, B., Crisosto, N., & Sir-Petermann, T. (2013). Placental steroidogenesis in pregnant women with polycystic ovary syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 166(2), 151–155. https://doi.org/10.1016/j.ejogrb.2012.10.015CrossRefPubMed

Matias, S. L., Pearl, M., Lyall, K., Croen, L. A., Kral, T. V. E., Fallin, D., Lee, Li-Ching., Bradley, Chyrise B., Schieve, Laura A., & Windham, G. C. (2021). Maternal prepregnancy weight and gestational weight gain in association with autism and developmental disorders in offspring. Obesity (Silver Spring), 29(9), 1554–1564. https://doi.org/10.1002/oby.23228CrossRefPubMed

Muratori, F., Narzisi, A., Tancredi, R., Cosenza, A., Calugi, S., Saviozzi, I., Santocchi, E., & Calderoni, S. (2011). The CBCL 1.5–5 and the identification of preschoolers with autism in Italy. Epidemiology and Psychiatric Sciences, 20(4), 329–338. https://doi.org/10.1017/s204579601100045xCrossRefPubMed

Narzisi, A., Calderoni, S., Maestro, S., Calugi, S., Mottes, E., & Muratori, F. (2013). Child Behavior Check List 1½-5 as a tool to identify toddlers with autism spectrum disorders: A case-control study. Research in Developmental Disabilities, 34(4), 1179–1189. https://doi.org/10.1016/j.ridd.2012.12.020CrossRefPubMed

Nguyen, T. V. (2018). Developmental effects of androgens in the human brain. Journal of Neuroendocrinology. https://doi.org/10.1111/jne.12486CrossRefPubMed

O’Leary, P., Boyne, P., Flett, P., Beilby, J., & James, I. (1991). Longitudinal assessment of changes in reproductive hormones during normal pregnancy. Clinical Chemistry, 37(5), 667–672.CrossRefPubMed

Organization, W. H. (2019). International Statistical Classification of Diseases (ICD-11).

Ostatníková, D., Lakatošová, S., Babková, J., Hodosy, J., & Celec, P. (2020). Testosterone and the brain: From cognition to autism. Physiological Research, 69(Suppl 3), S403–S419. https://doi.org/10.33549/physiolres.934592CrossRefPubMedPubMedCentral

Palm, C. V. B., Glintborg, D., Kyhl, H. B., McIntyre, H. D., Jensen, R. C., Jensen, T. K., Møller, D., & Andersen, M. (2018). Polycystic ovary syndrome and hyperglycaemia in pregnancy. A narrative review and results from a prospective Danish cohort study. Diabetes Research and Clinical Practice. https://doi.org/10.1016/j.diabres.2018.04.030CrossRefPubMed

Park, B. Y., Lee, B. K., Burstyn, I., Tabb, L. P., Keelan, J. A., Croen, L. A., Whitehouse, J. O., Fallin, M. D., Hertz-Picciotto, I., Montgomery, O., & Newschaffer, C. J. (2017). Umbilical cord blood androgen levels and ASD-related phenotypes at 12 and 36 months in an enriched risk cohort study. Molecular Autism, 8, 3. https://doi.org/10.1186/s13229-017-0118-zCrossRefPubMedPubMedCentral

Priskorn, L., Petersen, J. H., Jørgensen, N., Kyhl, H. B., Andersen, M. S., Main, K. M., Andersson, A.-M., Skakkebaek, N. E., & Jensen, T. K. (2018). Anogenital distance as a phenotypic signature through infancy. Pediatric Research, 83(3), 573–579. https://doi.org/10.1038/pr.2017.287CrossRefPubMed

Raperport, C., & Homburg, R. (2019). The source of polycystic ovarian syndrome. Clin Med Insights Reprod Health, 13, 1179558119871467. https://doi.org/10.1177/1179558119871467CrossRefPubMedPubMedCentral

Recabarren, S. E., Padmanabhan, V., Codner, E., Lobos, A., Durán, C., Vidal, M., Foster, D. L., & Sir-Petermann, T. (2005). Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone. American Journal of Physiology Endocrinology and Metabolism, 289(5), E801-806. https://doi.org/10.1152/ajpendo.00107.2005CrossRefPubMed

Rescorla, L. (1988). Cluster analytic identification of autistic preschoolers. Journal of Autism and Developmental Disorders, 18(4), 475–492. https://doi.org/10.1007/bf02211868CrossRefPubMed

Rescorla, L. A., Adams, A., & Ivanova, M. Y. (2020). The CBCL/1½-5’s DSM-ASD scale: Confirmatory factor analyses across 24 societies. Journal of Autism and Developmental Disorders, 50(9), 3326–3340. https://doi.org/10.1007/s10803-019-04189-5CrossRefPubMed

Rescorla, L. A., Ghassabian, A., Ivanova, M. Y., Jaddoe, V. W., Verhulst, F. C., & Tiemeier, H. (2019). Structure, longitudinal invariance, and stability of the Child Behavior Checklist 1½–5’s Diagnostic and Statistical Manual of Mental Disorders-Autism Spectrum Disorder scale: Findings from Generation R (Rotterdam). Autism, 23(1), 223–235. https://doi.org/10.1177/1362361317736201

Rescorla, L. A., Given, C., Glynn, S., Ivanova, M. Y., & Achenbach, T. M. (2019). International comparisons of autism spectrum disorder behaviors in preschoolers rated by parents and caregivers/teachers. Autism, 23(8), 2043–2054. https://doi.org/10.1177/1362361319839151

Rescorla, L., Kim, Y. A., & Oh, K. J. (2015). Screening for ASD with the Korean CBCL/1½-5. Journal of Autism and Developmental Disorders, 45(12), 4039–4050. https://doi.org/10.1007/s10803-014-2255-yCrossRefPubMed

. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertility and Sterility, 81(1), 19–25.

Rivarola, M. A., Forest, M. G., & Migeon, C. J. (1968). Testosterone, androstenedione and dehydroepiandrosterone in plasma during pregnancy and at delivery: Concentration and protein binding. Journal of Clinical Endocrinology and Metabolism, 28(1), 34–40. https://doi.org/10.1210/jcem-28-1-34CrossRefPubMed

Sathishkumar, K., Elkins, R., Chinnathambi, V., Gao, H., Hankins, G. D., & Yallampalli, C. (2011). Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport. Reproductive Biology and Endocrinology, 9, 110. https://doi.org/10.1186/1477-7827-9-110CrossRefPubMedPubMedCentral

Sathyanarayana, S., Grady, R., Redmon, J. B., Ivicek, K., Barrett, E., Janssen, S., Nguyen, R., & Swan, S. H. (2015). Anogenital distance and penile width measurements in The Infant Development and the Environment Study (TIDES): Methods and predictors. Journal of Pediatric Urology, 11(2), 76.e71-76. https://doi.org/10.1016/j.jpurol.2014.11.018CrossRef

Sikora, D. M., Hall, T. A., Hartley, S. L., Gerrard-Morris, A. E., & Cagle, S. (2008). Does parent report of behavior differ across ADOS-G classifications: Analysis of scores from the CBCL and GARS. Journal of Autism and Developmental Disorders, 38(3), 440–448. https://doi.org/10.1007/s10803-007-0407-zCrossRefPubMed

So, P., Greaves-Lord, K., van der Ende, J., Verhulst, F. C., Rescorla, L., & de Nijs, P. F. (2013). Using the Child Behavior Checklist and the Teacher’s Report Form for identification of children with autism spectrum disorders. Autism, 17(5), 595–607. https://doi.org/10.1177/1362361312448855CrossRefPubMed

Sun, M., Sun, B., Qiao, S., Feng, X., Li, Y., Zhang, S., Lin, Y., & Hou, L. (2020). Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome. Fertility and Sterility, 113(6), 1275-1285.e1272. https://doi.org/10.1016/j.fertnstert.2020.02.005CrossRefPubMed

Taylor, M. J., Martin, J., Lu, Y., Brikell, I., Lundström, S., Larsson, H., & Lichtenstein, P. (2019). Association of Genetic Risk Factors for Psychiatric Disorders and Traits of These Disorders in a Swedish Population Twin Sample. JAMA Psychiatry, 76(3), 280–289. https://doi.org/10.1001/jamapsychiatry.2018.3652CrossRefPubMed

Thankamony, A., Pasterski, V., Ong, K. K., Acerini, C. L., & Hughes, I. A. (2016). Anogenital distance as a marker of androgen exposure in humans. Andrology, 4(4), 616–625. https://doi.org/10.1111/andr.12156CrossRefPubMedPubMedCentral

Traver, S., Geoffray, M. M., Mazières, L., Geneviève, D., Michelon, C., Picot, M. C., & Baghdadli, A. (2021). Association between prenatal and perinatal factors and the severity of clinical presentation of children with ASD: Report from the ELENA COHORT. Journal of Psychiatric Research, 137, 634–642. https://doi.org/10.1016/j.jpsychires.2020.11.005CrossRefPubMed

Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999). A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism, 84(10), 3666–3672. https://doi.org/10.1210/jcem.84.10.6079CrossRefPubMed

Whitehouse, A. J., Mattes, E., Maybery, M. T., Dissanayake, C., Sawyer, M., Jones, R. M., Pennell, C. E., Keelan, J. A., & Hickey, M. (2012). Perinatal testosterone exposure and autistic-like traits in the general population: A longitudinal pregnancy-cohort study. Journal of Neurodevelopmental Disorders, 4(1), 25. https://doi.org/10.1186/1866-1955-4-25CrossRefPubMedPubMedCentral

Titel: Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort
Auteurs: Camilla V. B. Palm
Dorte Glintborg
Laura G. Find
Pia V. Larsen
Cilia M. Dalgaard
Henriette Boye
Tina K. Jensen
Anja F. Dreyer
Marianne S. Andersen
Niels Bilenberg
Publicatiedatum: 06-02-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 3/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-022-05446-w

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