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Journal of Autism and Developmental Disorders

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06-02-2022 | Original Paper

Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort

Auteurs: Camilla V. B. Palm, Dorte Glintborg, Laura G. Find, Pia V. Larsen, Cilia M. Dalgaard, Henriette Boye, Tina K. Jensen, Anja F. Dreyer, Marianne S. Andersen, Niels Bilenberg

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2023

Abstract

Fetal androgen exposure may be associated with autism spectrum disorder (ASD). We studied 1777 mother–child pairs in the prospective Odense Child Cohort. Prenatal androgen exposure was assessed by maternal 3rd trimester testosterone concentrations, maternal polycystic ovary syndrome (PCOS), and 3 months offspring anogenital distance. ASD traits were assessed at age 3 years with the ASD-symptom scale of the Child Behavior Checklist for ages 1½–5 years. Maternal testosterone was positively associated with traits of ASD in boys (p < 0.05). Maternal PCOS was associated with increased offspring ASD traits (p = 0.046), but became non-significant after excluding parental psychiatric diagnosis. Offspring anogenital distance was not linked to ASD traits. Higher prevalence of ASD in boys could be linked to higher susceptibility to fetal androgen exposure.

vorige artikel The Development and Validation of a Subscale for the School-Age Child Behavior CheckList to Screen for Autism Spectrum Disorder

volgende artikel “Self-compassion changed my life”: The self-compassion experiences of autistic and non-autistic adults and its relationship with mental health and psychological wellbeing

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Titel: Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort
Auteurs: Camilla V. B. Palm
Dorte Glintborg
Laura G. Find
Pia V. Larsen
Cilia M. Dalgaard
Henriette Boye
Tina K. Jensen
Anja F. Dreyer
Marianne S. Andersen
Niels Bilenberg
Publicatiedatum: 06-02-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 3/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-022-05446-w

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