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Journal of Autism and Developmental Disorders

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01-03-2015 | Original Paper

Prenatal and Neonatal Thyroid Stimulating Hormone Levels and Autism Spectrum Disorders

Auteurs: Vincent M. Yau, Marta Lutsky, Cathleen K. Yoshida, Bill Lasley, Martin Kharrazi, Gayle Windham, Nancy Gee, Lisa A. Croen

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2015

Abstract

Thyroid hormones are critical for normal brain development. This study examined autism spectrum disorders (ASD) and thyroid stimulating hormone (TSH) levels measured in mid-pregnancy maternal serum and infant blood after birth. Three groups of children born in Orange County, CA in 2000–2001were identified: ASD (n = 78), developmental delay (n = 45), and general population controls (GP) (n = 149). Samples were retrieved from prenatal and newborn screening specimen archives. Adjusted logistic regression models showed inverse associations between ASD and log transformed TSH levels in maternal serum samples (ASD vs. GP: OR [95 % CI] 0.33 [0.12–0.91], Early Onset ASD vs. GP: 0.31 [0.10–0.98]). Results for thyroid levels in newborn blood samples were similar though not significant (ASD vs. GP: 0.61 [0.18–2.04]).

vorige artikel Outcomes in Adult Life Among Siblings of Individuals with Autism

volgende artikel Sexuality in Adolescent Boys with Autism Spectrum Disorder: Self-reported Behaviours and Attitudes

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American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders DSM-IV-TR Fourth Edition (4th ed.). American Psychiatric Publication.

Andersen, S., Laurberg, P., Wu, C., Olsen, J. (2014). Attention deficit hyperactivity disorder and autism spectrum disorder in children born to mothers with thyroid dysfunction: a Danish nationwide cohort study. BJOG. doi:10.1111/1471-0528.12681. [Epub ahead of print].

Atladóttir, H. O., Thorsen, P., Østergaard, L., Schendel, D. E., Lemcke, S., Abdallah, M., et al. (2010). Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. Journal of Autism and Developmental Disorders, 40(12), 1423–1430. doi:10.1007/s10803-010-1006-y.CrossRefPubMed

Baloch, Z., Carayon, P., Conte-Devolx, B., Demers, L. M., Feldt-Rasmussen, U., Henry, J.-F., et al. (2003). Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid, 13(1), 3–126. doi:10.1089/105072503321086962.CrossRefPubMed

Baskin, H. J., Cobin, R. H., Duick, D. S., Gharib, H., Guttler, R. B., Kaplan, M. M., et al. (2002). American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocrine Practice, 8(6), 457–469.PubMed

Bernal, J., Guadaño-Ferraz, A., & Morte, B. (2003). perspectives in the study of thyroid hormone action on brain development and function. Thyroid, 13(11), 1005–1012. doi:10.1089/105072503770867174.CrossRefPubMed

Beversdorf, D. Q., Manning, S. E., Hillier, A., Anderson, S. L., Nordgren, R. E., Walters, S. E., et al. (2005). Timing of prenatal stressors and autism. Journal of Autism and Developmental Disorders, 35(4), 471–478. doi:10.1007/s10803-005-5037-8.CrossRefPubMed

CDC. (2014). Prevalence of autism spectrum disorder among children aged 8 years: Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2010. MMWR 63(No. SS-2):[1–21].

Cohen, D. J., Young, J. G., Lowe, T. L., & Harcherik, D. (1980). Thyroid hormone in autistic children. Journal of Autism and Developmental Disorders, 10(4), 445–450.CrossRefPubMed

Cole, L. A. (2009). New discoveries on the biology and detection of human chorionic gonadotropin. Reproductive Biology and Endocrinology RB&E, 7, 8. doi:10.1186/1477-7827-7-8.CrossRef

Croen, L. A., Braunschweig, D., Haapanen, L., Yoshida, C. K., Fireman, B., Grether, J. K., et al. (2008a). Maternal mid-pregnancy autoantibodies to fetal brain protein: The early markers for autism study. Biological Psychiatry, 64(7), 583–588. doi:10.1016/j.biopsych.2008.05.006.CrossRefPubMedCentralPubMed

Croen, L. A., Goines, P., Braunschweig, D., Yolken, R., Yoshida, C. K., Grether, J. K., et al. (2008b). Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) Study. Autism Research, 1(2), 130–137. doi:10.1002/aur.14.CrossRefPubMedCentralPubMed

Croen, L. A., Grether, J. K., & Selvin, S. (2002). Descriptive epidemiology of autism in a California population: Who is at risk? Journal of Autism and Developmental Disorders, 32(3), 217–224.CrossRefPubMed

Croen, L. A., Grether, J. K., Yoshida, C. K., Odouli, R., & Hendrick, V. (2011). Antidepressant use during pregnancy and childhood autism spectrum disorders. Archives of General Psychiatry, 68(11), 1104–1112. doi:10.1001/archgenpsychiatry.2011.73.CrossRefPubMed

De Escobar, G. M., Obregón, M. J., & del Rey, F. E. (2004). Maternal thyroid hormones early in pregnancy and fetal brain development. Best Practice and Research Clinical Endocrinology and Metabolism, 18(2), 225–248. doi:10.1016/j.beem.2004.03.012.CrossRefPubMed

Gottesfeld, Z., & Silverman, P. B. (1990). Developmental delays associated with prenatal alcohol exposure are reversed by thyroid hormone treatment. Neuroscience Letters, 109(1–2), 42–47.CrossRefPubMed

Groot, L. D., Abalovich, M., Alexander, E. K., Amino, N., Barbour, L., Cobin, R. H., et al. (2012). Management of thyroid dysfunction during pregnancy and postpartum: An Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 97(8), 2543–2565. doi:10.1210/jc.2011-2803.CrossRefPubMed

Haddow, J. E., Palomaki, G. E., Allan, W. C., Williams, J. R., Knight, G. J., Gagnon, J., et al. (1999). Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. New England Journal of Medicine, 341(8), 549–555. doi:10.1056/NEJM199908193410801.CrossRefPubMed

Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., et al. (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of General Psychiatry, 68(11), 1095–1102. doi:10.1001/archgenpsychiatry.2011.76.CrossRefPubMed

Hashimoto, T., Aihara, R., Tayama, M., Miyazaki, M., Shirakawa, Y., & Kuroda, Y. (1991). Reduced thyroid-stimulating hormone response to thyrotropin-releasing hormone in autistic boys. Developmental Medicine and Child Neurology, 33(4), 313–319.CrossRefPubMed

Henrichs, J., Bongers-Schokking, J. J., Schenk, J. J., Ghassabian, A., Schmidt, H. G., Visser, T. J., et al. (2010). Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: The generation R study. The Journal of Clinical Endocrinology and Metabolism, 95(9), 4227–4234. doi:10.1210/jc.2010-0415.CrossRefPubMed

Hershman, J. M. (2008). The role of human chorionic gonadotropin as a thyroid stimulator in normal pregnancy. The Journal of Clinical Endocrinology and Metabolism, 93(9), 3305–3306. doi:10.1210/jc.2008-1461.CrossRefPubMed

Hoshiko, S., Grether, J. K., Windham, G. C., Smith, D., & Fessel, K. (2011). Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? Autism Research, 4(6), 456–463. doi:10.1002/aur.219.CrossRefPubMed

Ishimoto, H., & Jaffe, R. B. (2011). Development and function of the human fetal adrenal cortex: A key component in the feto-placental unit. Endocrine Reviews, 32(3), 317–355. doi:10.1210/er.2010-0001.CrossRefPubMedCentralPubMed

Lavado-Autric, R., Ausó, E., García-Velasco, J. V., del Arufe, M., Escobar del Rey, F., Berbel, P., et al. (2003). Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. The Journal of Clinical Investigation, 111(7), 1073–1082. doi:10.1172/JCI16262.CrossRefPubMedCentralPubMed

Lawler, C. P., Croen, L. A., Grether, J. K., & Van de Water, J. (2004). Identifying environmental contributions to autism: Provocative clues and false leads. Mental Retardation and Developmental Disabilities Research Reviews, 10(4), 292–302. doi:10.1002/mrdd.20043.CrossRefPubMed

Lord, C., Cook, E. H., Leventhal, B. L., & Amaral, D. G. (2000). Autism spectrum disorders. Neuron, 28(2), 355–363. doi:10.1016/S0896-6273(00)00115-X.CrossRefPubMed

Magnusson, C., Rai, D., Goodman, A., Lundberg, M., Idring, S., Svensson, A., et al. (2012). Migration and autism spectrum disorder: population-based study. British Journal of Psychiatry, 201, 109–115. doi:10.1192/bjp.bp.111.095125.CrossRefPubMed

Molloy, C. A., Morrow, A. L., Meinzen-Derr, J., Dawson, G., Bernier, R., Dunn, M., et al. (2006). Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: A CPEA Study. Journal of Autism and Developmental Disorders, 36(3), 317–324. doi:10.1007/s10803-005-0071-0.CrossRefPubMed

Morreale de Escobar, G., Obregon, M. J., & Escobar del Rey, F. (2004). Role of thyroid hormone during early brain development. European Journal of Endocrinology/European Federation of Endocrine Societies, 151(Suppl 3), U25–U37.CrossRefPubMed

Nordenbæk, C., Jørgensen, M., Kyvik, K. O., & Bilenberg, N. (2013). A Danish population-based twin study on autism spectrum disorders. European Child and Adolescent Psychiatry. doi:10.1007/s00787-013-0419-5.

Pillitteri, A., & Pillitteri, A. (2010). Maternal and child health nursing: Care of the childbearing and childrearing family. Philadelphia: Wolters Kluwer Health/Lippincott Williams and Wilkins.

Pop, V. J., Brouwers, E. P., Vader, H. L., Vulsma, T., van Baar, A. L., & de Vijlder, J. J. (2003). Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clinical Endocrinology, 59(3), 282–288.CrossRefPubMed

Posthuma, D., & Polderman, T. J. C. (2013). What have we learned from recent twin studies about the etiology of neurodevelopmental disorders? Current Opinion in Neurology, 26(2), 111–121. doi:10.1097/WCO.0b013e32835f19c3.CrossRefPubMed

Rodier, P. M. (2004). Environmental causes of central nervous system maldevelopment. Pediatrics, 113(4 Suppl), 1076–1083.PubMed

Román, G. C., Ghassabian, A., Bongers-Schokking, J. J., Jaddoe, V. W. V., Hofman, A., de Rijke, Y. B., Tiemeier, H. (2013). Association of gestational maternal hypothyroxinemia and increased autism risk. Annals of Neurology. doi:10.1002/ana.23976.

Sadamatsu, M., Kanai, H., Xu, X., Liu, Y., & Kato, N. (2006). Review of animal models for autism: implication of thyroid hormone. Congenital Anomalies, 46(1), 1–9. doi:10.1111/j.1741-4520.2006.00094.x.CrossRefPubMed

Scher, M. S. (2001). Fetal and neonatal neurologic consultations: Identifying brain disorders in the context of fetal-maternal-placental disease. Seminars in Pediatric Neurology, 8(2), 55–73.CrossRefPubMed

Serón-Ferré, M., Lawrence, C. C., & Jaffe, R. B. (1978). Role of hCG in regulation of the fetal zone of the human fetal adrenal gland. The Journal of Clinical Endocrinology and Metabolism, 46(5), 834–837.CrossRefPubMed

Soldin, O. P., Lai, S., Lamm, S. H., & Mosee, S. (2003). Lack of a relation between human neonatal thyroxine and pediatric neurobehavioral disorders. Thyroid, 13(2), 193–198. doi:10.1089/105072503321319503.CrossRefPubMedCentralPubMed

Surén, P., Roth, C., Bresnahan, M., Haugen, M., Hornig, M., Hirtz, D., et al. (2013). Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA, 309(6), 570–577. doi:10.1001/jama.2012.155925.CrossRefPubMedCentralPubMed

Sweeten, T. L., Bowyer, S. L., Posey, D. J., Halberstadt, G. M., & McDougle, C. J. (2003). Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics, 112(5), e420. doi:10.1542/peds.112.5.e420.CrossRefPubMed

Szatmari, P., Jones, M. B., Zwaigenbaum, L., & MacLean, J. E. (1998). Genetics of autism: overview and new directions. Journal of Autism and Developmental Disorders, 28(5), 351–368.CrossRefPubMed

Volk, H. E., Lurmann, F., Penfold, B., Hertz-Picciotto, I., & McConnell, R. (2013). Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry, 70(1), 71–77. doi:10.1001/jamapsychiatry.2013.266.CrossRefPubMedCentralPubMed

Walker, C. K., Anderson, K. W., Milano, K. M., Ye, S., Tancredi, D. J., Pessah, I. N., et al. (2013). Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism. Biological Psychiatry, 74(3), 204–211. doi:10.1016/j.biopsych.2013.03.006.CrossRefPubMedCentralPubMed

Williams, G. R. (2008). Neurodevelopmental and neurophysiological actions of thyroid hormone. Journal of Neuroendocrinology, 20(6), 784–794. doi:10.1111/j.1365-2826.2008.01733.x.CrossRefPubMed

Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003). Prevalence of autism in a US metropolitan area. JAMA, 289(1), 49–55.CrossRefPubMed

Zerbo, O., Qian, Y., Yoshida, C., Grether, J. K., Van de Water, J., & Croen, L. A. (2013). Maternal infection during pregnancy and autism spectrum disorders. J Autism Dev Disord. doi:10.1007/s10803-013-2016-3.

Titel: Prenatal and Neonatal Thyroid Stimulating Hormone Levels and Autism Spectrum Disorders
Auteurs: Vincent M. Yau
Marta Lutsky
Cathleen K. Yoshida
Bill Lasley
Martin Kharrazi
Gayle Windham
Nancy Gee
Lisa A. Croen
Publicatiedatum: 01-03-2015
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 3/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-014-2227-2

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