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Gepubliceerd in: Netherlands Heart Journal 12/2008

01-12-2008 | review article

Pregnancy in women with prosthetic heart valves

Auteurs: P. G. Pieper, A. Balci, A. P. Van Dijk

Gepubliceerd in: Netherlands Heart Journal | Uitgave 12/2008

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Abstract

Pregnancy in women with mechanical valve prostheses has a high maternal complication rate including valve thrombosis and death. Coumarin derivatives are relatively safe for the mother with a lower incidence of valve thrombosis than un-fractionated and low-molecular-weight heparin, but carry the risk of embryopathy, which is probably dose-dependent. The different anticoagulation regimens are discussed in this review. When valve thrombosis occurs during pregnancy, thrombolysis is the preferable therapeutic option. Bioprostheses have a more favourable pregnancy outcome than mechanical prostheses but due to the high re-operation rate in young women they do not constitute the ideal alternative. When women with native valve stenosis need pre-pregnancy intervention, mitral balloon valvuloplasty is the best option in mitral stenosis, while the Ross operation or homograft implantation may be the preferable surgical regimen in aortic stenosis. (Neth Heart J 2008;16:406-11.)
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Metagegevens
Titel
Pregnancy in women with prosthetic heart valves
Auteurs
P. G. Pieper
A. Balci
A. P. Van Dijk
Publicatiedatum
01-12-2008
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 12/2008
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03086187

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