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Gepubliceerd in: Netherlands Heart Journal 12/2008

01-12-2008 | case report

Pregnancy and the risk of torsades de pointes in congenital long-QT syndrome

Auteurs: P. G. Meregalli, I. C. D. Westendorp, H. L. Tan, P. Elsman, W. E. M. Kok, A. A. M. Wilde

Gepubliceerd in: Netherlands Heart Journal | Uitgave 12/2008

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Abstract

Patients with congenital long-QT syndrome (LQTS) are at increased risk of ventricular arrhythmias during stressful situations. Large-scale studies have pointed out that affected individuals are particularly at risk in the period following pregnancy (post-partum). This is recognised especially for women with an LQTS type 2. Here, we describe two cases of young women with LQTS type 2, both admitted to our institution with symptomatic torsades de pointes a few weeks after delivery. Both patients carried a mutation in the KCNH2 gene. One patient was nullipara, while the other had had an uneventful previous pregnancy. In both cases treatment with a β-blocker did not prevent life-threatening cardiac arrhythmias. The risk of arrhythmias is thought to gradually decrease to pre-pregnancy values in the nine months after delivery. Considering the difficulties related to continuous monitoring of a patient for such a long period and the desire of these patients to have more children in the foreseeable future, ICD implantation was performed. (Neth Heart J 2008;16:422-5.)
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Metagegevens
Titel
Pregnancy and the risk of torsades de pointes in congenital long-QT syndrome
Auteurs
P. G. Meregalli
I. C. D. Westendorp
H. L. Tan
P. Elsman
W. E. M. Kok
A. A. M. Wilde
Publicatiedatum
01-12-2008
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 12/2008
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03086191

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