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06-04-2017

Predictors of the course of quality of life during therapy in women with primary breast cancer

Auteurs: Achim Wöckel, L. Schwentner, M. Krockenberger, R. Kreienberg, W. Janni, M. Wischnewsky, Kühn Thorsten, Flock Felix, Felberbaum Riccardo, M. Blettner, S. Singer

Gepubliceerd in: Quality of Life Research | Uitgave 8/2017

Abstract

Purpose

Multimodal therapies affect the quality of life (QoL) of patients with primary breast cancer (PBC). The objectives of this prospective study were to explore the changes in QoL from diagnosis to conclusion of adjuvant therapy and to identify predictive factors of QoL.

Methods

Before surgery (t1), before onset of adjuvant treatment (t2) and after completion of adjuvant chemo- or radiotherapy (t3), patients with PBC (n = 759) completed the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire, Charlson Comorbidity Index, Patient Health Questionnaire and Perceived Involvement in Care Scales. Predictors of the course of global QoL were estimated using multinomial logistic regression. Effect estimates are odds ratios (OR) and their 95% confidence intervals (CIs).

Results

Global QoL improved between t1 and t3, while physical functioning, emotional functioning and fatigue deteriorated. QoL before surgery was more often poor in patients <60 years (OR 2.2, 95% CI 1.5–3.1) and in those with comorbid mental illnesses (OR 8.6, CI 5.4–13.7). Forty-seven percentage reported good global QoL both at t1 and at t3. QoL improved in 28%, worsened in 10% and remained poor in 15%. Compared to patients with consistently good global QoL, a course of improving QoL was more often seen in patients who had received a mastectomy and in those with intense fear of treatment before surgery. A course of decreasing QoL was more often found in patients who were treated with chemotherapy. QoL stayed poor in patients with chemotherapy, mastectomy and intense fear. There was no evidence that radiotherapy, progressive disease or perceived involvement impact the course of QoL.

Conclusions

Younger age and comorbid mental illnesses are associated with poor QoL pre-therapeutically. QoL is more likely to stay or become poor in patients who receive chemotherapy.

vorige artikel What contributes to long-term quality of life in breast cancer patients who are undergoing surgery? Results of a multidimensional study

volgende artikel Pathways linking obesity to health-related quality of life

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Titel: Predictors of the course of quality of life during therapy in women with primary breast cancer
Auteurs: Achim Wöckel
L. Schwentner
M. Krockenberger
R. Kreienberg
W. Janni
M. Wischnewsky
Kühn Thorsten
Flock Felix
Felberbaum Riccardo
M. Blettner
S. Singer
Publicatiedatum: 06-04-2017
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 8/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-017-1570-0

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Abstract

Purpose

Methods

Results

Conclusions

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