Skip to main content
Top
Gepubliceerd in:

04-08-2016

Predictors of health-related quality of life and association with survival may identify colorectal cancer patients at high risk of poor prognosis

Auteurs: Monica E. Reyes, Yuanqing Ye, Yeling Zhou, Alexander Liang, Scott Kopetz, M. Alma Rodriquez, Xifeng Wu, Michelle A. T. Hildebrandt

Gepubliceerd in: Quality of Life Research | Uitgave 2/2017

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Purpose

To investigate the mediators of health-related quality of life (HR-QoL) in colorectal cancer (CRC) patients and effect on overall survival.

Methods

We analyzed baseline (within 1 year of diagnosis) SF-12v1 questionnaire data from 3734 CRC patients and assessed the differences in mental composite scores (MCS) and physical composite scores (PCS) by socio-demographics and risks of poor HR-QoL by these factors. Hazard ratios were generated using univariate Cox regression for MCS and PCS dichotomized using the normalized scoring-based mean of 50 and survival estimates generated using the Kaplan–Meier method.

Results

Differences in MCS and PCS were identified by sex, age, education level, alcohol use, tobacco use, and stage. Race, marital status, and cancer site differed only by PCS. Being female, never married, former alcohol user, or with stage IV disease significantly increased risk of a poor HR-QoL, with magnitudes of risk from 1.25- to 1.97-fold. Higher education level had a protective effect (MCS: P trend = 2.32 × 10−7; PCS: P trend = 5.62 × 10−14). Hispanics and African-Americans had a 1.35- and 1.57-fold risk of poor PCS, and increase in age had a protective effect for risk of poor MCS (P trend = 1.84 × 10−7). Poor MCS or PCS were associated with poor prognosis and decreased survival at 5 years (HRMCS 1.57, 95 % CI 1.41–1.76 and HRPCS 2.38, 95 % CI 2.08–2.72), and both remained significant when adjusting for age, gender, race, education level, tumor stage, and tumor site.

Conclusions

Our findings identify potential mediators for HR-QoL and suggest that baseline HR-QoL assessment may be prognostic for CRC.
Literatuur
3.
go back to reference Schag, C. A., Ganz, P. A., Wing, D. S., Sim, M. S., & Lee, J. J. (1994). Quality of life in adult survivors of lung, colon and prostate cancer. Quality of Life Research, 3(2), 127–141.CrossRefPubMed Schag, C. A., Ganz, P. A., Wing, D. S., Sim, M. S., & Lee, J. J. (1994). Quality of life in adult survivors of lung, colon and prostate cancer. Quality of Life Research, 3(2), 127–141.CrossRefPubMed
5.
go back to reference Mols, F., Thong, M. S., van de Poll-Franse, L. V., Roukema, J. A., & Denollet, J. (2012). Type D (distressed) personality is associated with poor quality of life and mental health among 3080 cancer survivors. Journal of Affective Disorders, 136(1–2), 26–34. doi:10.1016/j.jad.2011.08.034.CrossRefPubMed Mols, F., Thong, M. S., van de Poll-Franse, L. V., Roukema, J. A., & Denollet, J. (2012). Type D (distressed) personality is associated with poor quality of life and mental health among 3080 cancer survivors. Journal of Affective Disorders, 136(1–2), 26–34. doi:10.​1016/​j.​jad.​2011.​08.​034.CrossRefPubMed
6.
go back to reference Zhang, J. K., Fang, L. L., Zhang, D. W., Jin, Q., Wu, X. M., Liu, J. C., et al. (2016). Type D personality is associated with delaying patients to medical assessment and poor quality of life among rectal cancer survivors. International Journal of Colorectal Disease, 31(1), 75–85. doi:10.1007/s00384-015-2333-4.CrossRefPubMed Zhang, J. K., Fang, L. L., Zhang, D. W., Jin, Q., Wu, X. M., Liu, J. C., et al. (2016). Type D personality is associated with delaying patients to medical assessment and poor quality of life among rectal cancer survivors. International Journal of Colorectal Disease, 31(1), 75–85. doi:10.​1007/​s00384-015-2333-4.CrossRefPubMed
7.
go back to reference Kroz, M., Reif, M., Bussing, A., Zerm, R., Feder, G., Bockelbrink, A., et al. (2011). Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? Results of a prospective outcome study. Health Qual Life Outcomes, 9, 85. doi:10.1186/1477-7525-9-85.CrossRefPubMedPubMedCentral Kroz, M., Reif, M., Bussing, A., Zerm, R., Feder, G., Bockelbrink, A., et al. (2011). Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? Results of a prospective outcome study. Health Qual Life Outcomes, 9, 85. doi:10.​1186/​1477-7525-9-85.CrossRefPubMedPubMedCentral
8.
go back to reference Vallance, J. K., Boyle, T., Courneya, K. S., & Lynch, B. M. (2014). Associations of objectively assessed physical activity and sedentary time with health-related quality of life among colon cancer survivors. Cancer, 120(18), 2919–2926. doi:10.1002/cncr.28779.CrossRefPubMed Vallance, J. K., Boyle, T., Courneya, K. S., & Lynch, B. M. (2014). Associations of objectively assessed physical activity and sedentary time with health-related quality of life among colon cancer survivors. Cancer, 120(18), 2919–2926. doi:10.​1002/​cncr.​28779.CrossRefPubMed
9.
go back to reference Cella, D., Cappelleri, J. C., Bushmakin, A., Charbonneau, C., Li, J. Z., Kim, S. T., et al. (2009). Quality of life predicts progression-free survival in patients with metastatic renal cell carcinoma treated with sunitinib versus interferon alfa. Journal of Oncology Practice, 5(2), 66–70. doi:10.1200/JOP.0922004.CrossRefPubMedPubMedCentral Cella, D., Cappelleri, J. C., Bushmakin, A., Charbonneau, C., Li, J. Z., Kim, S. T., et al. (2009). Quality of life predicts progression-free survival in patients with metastatic renal cell carcinoma treated with sunitinib versus interferon alfa. Journal of Oncology Practice, 5(2), 66–70. doi:10.​1200/​JOP.​0922004.CrossRefPubMedPubMedCentral
10.
go back to reference Cella, D., Bushmakin, A. G., Cappelleri, J. C., Charbonneau, C., Michaelson, M. D., & Motzer, R. J. (2012). Baseline quality of life as a prognostic survival tool in patients receiving sunitinib for metastatic renal cell carcinoma. British Journal of Cancer, 106(4), 646–650. doi:10.1038/bjc.2011.589.CrossRefPubMedPubMedCentral Cella, D., Bushmakin, A. G., Cappelleri, J. C., Charbonneau, C., Michaelson, M. D., & Motzer, R. J. (2012). Baseline quality of life as a prognostic survival tool in patients receiving sunitinib for metastatic renal cell carcinoma. British Journal of Cancer, 106(4), 646–650. doi:10.​1038/​bjc.​2011.​589.CrossRefPubMedPubMedCentral
11.
go back to reference Quinten, C., Coens, C., Mauer, M., Comte, S., Sprangers, M. A., Cleeland, C., et al. (2009). Baseline quality of life as a prognostic indicator of survival: A meta-analysis of individual patient data from EORTC clinical trials. The lancet Oncology, 10(9), 865–871. doi:10.1016/S1470-2045(09)70200-1.CrossRefPubMed Quinten, C., Coens, C., Mauer, M., Comte, S., Sprangers, M. A., Cleeland, C., et al. (2009). Baseline quality of life as a prognostic indicator of survival: A meta-analysis of individual patient data from EORTC clinical trials. The lancet Oncology, 10(9), 865–871. doi:10.​1016/​S1470-2045(09)70200-1.CrossRefPubMed
12.
go back to reference Efficace, F., Bottomley, A., Coens, C., Van Steen, K., Conroy, T., Schoffski, P., et al. (2006). Does a patient’s self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer? European Journal of Cancer, 42(1), 42–49. doi:10.1016/j.ejca.2005.07.025.CrossRefPubMed Efficace, F., Bottomley, A., Coens, C., Van Steen, K., Conroy, T., Schoffski, P., et al. (2006). Does a patient’s self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer? European Journal of Cancer, 42(1), 42–49. doi:10.​1016/​j.​ejca.​2005.​07.​025.CrossRefPubMed
13.
go back to reference Conroy, T., Bleiberg, H., & Glimelius, B. (2003). Quality of life in patients with advanced colorectal cancer: What has been learnt? European Journal of Cancer, 39(3), 287–294.CrossRefPubMed Conroy, T., Bleiberg, H., & Glimelius, B. (2003). Quality of life in patients with advanced colorectal cancer: What has been learnt? European Journal of Cancer, 39(3), 287–294.CrossRefPubMed
14.
go back to reference Mauer, M., Bottomley, A., Coens, C., & Gotay, C. (2008). Prognostic factor analysis of health-related quality of life data in cancer: A statistical methodological evaluation. Expert Review of Pharmacoeconomics & Outcomes Research, 8(2), 179–196. doi:10.1586/14737167.8.2.179.CrossRef Mauer, M., Bottomley, A., Coens, C., & Gotay, C. (2008). Prognostic factor analysis of health-related quality of life data in cancer: A statistical methodological evaluation. Expert Review of Pharmacoeconomics & Outcomes Research, 8(2), 179–196. doi:10.​1586/​14737167.​8.​2.​179.CrossRef
16.
go back to reference Maisey, N. R., Norman, A., Watson, M., Allen, M. J., Hill, M. E., & Cunningham, D. (2002). Baseline quality of life predicts survival in patients with advanced colorectal cancer. European Journal of Cancer, 38(10), 1351–1357.CrossRefPubMed Maisey, N. R., Norman, A., Watson, M., Allen, M. J., Hill, M. E., & Cunningham, D. (2002). Baseline quality of life predicts survival in patients with advanced colorectal cancer. European Journal of Cancer, 38(10), 1351–1357.CrossRefPubMed
17.
go back to reference Whynes, D. K., Neilson, A. R., Robinson, M. H., & Hardcastle, J. D. (1994). Colorectal cancer screening and quality of life. Quality of Life Research, 3(3), 191–198.CrossRefPubMed Whynes, D. K., Neilson, A. R., Robinson, M. H., & Hardcastle, J. D. (1994). Colorectal cancer screening and quality of life. Quality of Life Research, 3(3), 191–198.CrossRefPubMed
18.
go back to reference Ware, J, Jr., Kosinski, M., & Keller, S. D. (1996). A 12-Item Short-Form Health Survey: Construction of scales and preliminary tests of reliability and validity. Medical Care, 34(3), 220–233.CrossRefPubMed Ware, J, Jr., Kosinski, M., & Keller, S. D. (1996). A 12-Item Short-Form Health Survey: Construction of scales and preliminary tests of reliability and validity. Medical Care, 34(3), 220–233.CrossRefPubMed
19.
go back to reference Cella, D. F., & Tulsky, D. S. (1993). Quality of life in cancer: Definition, purpose, and method of measurement. Cancer Investigation, 11(3), 327–336.CrossRefPubMed Cella, D. F., & Tulsky, D. S. (1993). Quality of life in cancer: Definition, purpose, and method of measurement. Cancer Investigation, 11(3), 327–336.CrossRefPubMed
21.
go back to reference Ware, J. E, Jr., & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30(6), 473–483.CrossRefPubMed Ware, J. E, Jr., & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30(6), 473–483.CrossRefPubMed
22.
go back to reference Zack, M. M., & Centers for Disease, C., & Prevention. (2013). Health-related quality of life-United States, 2006 and 2010. MMWR Surveillance Summaries, 62(Suppl 3), 105–111. Zack, M. M., & Centers for Disease, C., & Prevention. (2013). Health-related quality of life-United States, 2006 and 2010. MMWR Surveillance Summaries, 62(Suppl 3), 105–111.
23.
go back to reference Dunlop, D. D., Song, J., Lyons, J. S., Manheim, L. M., & Chang, R. W. (2003). Racial/ethnic differences in rates of depression among preretirement adults. American Journal of Public Health, 93(11), 1945–1952.CrossRefPubMedPubMedCentral Dunlop, D. D., Song, J., Lyons, J. S., Manheim, L. M., & Chang, R. W. (2003). Racial/ethnic differences in rates of depression among preretirement adults. American Journal of Public Health, 93(11), 1945–1952.CrossRefPubMedPubMedCentral
24.
go back to reference Tawk, R., Abner, A., Ashford, A., & Brown, C. P. (2015). Differences in colorectal cancer outcomes by race and insurance. International Journal of Environmental Research and Public Health,. doi:10.3390/ijerph13010048. Tawk, R., Abner, A., Ashford, A., & Brown, C. P. (2015). Differences in colorectal cancer outcomes by race and insurance. International Journal of Environmental Research and Public Health,. doi:10.​3390/​ijerph13010048.
26.
go back to reference Zahran, H. S., Kobau, R., Moriarty, D. G., Zack, M. M., Holt, J., Donehoo, R., et al. (2005). Health-related quality of life surveillance—United States, 1993–2002. MMWR Surveillance Summaries, 54(4), 1–35. Zahran, H. S., Kobau, R., Moriarty, D. G., Zack, M. M., Holt, J., Donehoo, R., et al. (2005). Health-related quality of life surveillance—United States, 1993–2002. MMWR Surveillance Summaries, 54(4), 1–35.
27.
go back to reference Arndt, V., Merx, H., Stegmaier, C., Ziegler, H., & Brenner, H. (2004). Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: A population-based study. Journal of Clinical Oncology, 22(23), 4829–4836. doi:10.1200/JCO.2004.02.018.CrossRefPubMed Arndt, V., Merx, H., Stegmaier, C., Ziegler, H., & Brenner, H. (2004). Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: A population-based study. Journal of Clinical Oncology, 22(23), 4829–4836. doi:10.​1200/​JCO.​2004.​02.​018.CrossRefPubMed
28.
go back to reference Kind, P., Dolan, P., Gudex, C., & Williams, A. (1998). Variations in population health status: Results from a United Kingdom national questionnaire survey. BMJ, 316(7133), 736–741.CrossRefPubMedPubMedCentral Kind, P., Dolan, P., Gudex, C., & Williams, A. (1998). Variations in population health status: Results from a United Kingdom national questionnaire survey. BMJ, 316(7133), 736–741.CrossRefPubMedPubMedCentral
29.
go back to reference Barile, J. P., Mitchell, S. A., Thompson, W. W., Zack, M. M., Reeve, B. B., Cella, D., et al. (2015). Patterns of chronic conditions and their associations with behaviors and quality of life, 2010. Preventing Chronic Disease, 12, E222. doi:10.5888/pcd12.150179.PubMed Barile, J. P., Mitchell, S. A., Thompson, W. W., Zack, M. M., Reeve, B. B., Cella, D., et al. (2015). Patterns of chronic conditions and their associations with behaviors and quality of life, 2010. Preventing Chronic Disease, 12, E222. doi:10.​5888/​pcd12.​150179.PubMed
30.
go back to reference Religioni, U., Czerw, A., & Deptala, A. (2015). Acceptance of cancer in patients diagnosed with lung, breast, colorectal and prostate carcinoma. Iranian Journal of Public Health, 44(8), 1135–1142.PubMedPubMedCentral Religioni, U., Czerw, A., & Deptala, A. (2015). Acceptance of cancer in patients diagnosed with lung, breast, colorectal and prostate carcinoma. Iranian Journal of Public Health, 44(8), 1135–1142.PubMedPubMedCentral
31.
go back to reference Owusu, D., Quinn, M., & Wang, K. S. (2015). Alcohol consumption, depression, insomnia and colorectal cancer screening: Racial differences. International Journal of High Risk Behaviors & Addiction, 4(2), e23424. doi:10.5812/ijhrba.4(2)2015.23424.CrossRef Owusu, D., Quinn, M., & Wang, K. S. (2015). Alcohol consumption, depression, insomnia and colorectal cancer screening: Racial differences. International Journal of High Risk Behaviors & Addiction, 4(2), e23424. doi:10.​5812/​ijhrba.​4(2)2015.​23424.CrossRef
32.
go back to reference Scheithauer, W., Rosen, H., Kornek, G. V., Sebesta, C., & Depisch, D. (1993). Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer. BMJ, 306(6880), 752–755.CrossRefPubMedPubMedCentral Scheithauer, W., Rosen, H., Kornek, G. V., Sebesta, C., & Depisch, D. (1993). Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer. BMJ, 306(6880), 752–755.CrossRefPubMedPubMedCentral
33.
go back to reference Akyol, M., Ulger, E., Alacacioglu, A., Kucukzeybek, Y., Bayoglu, V., Yildiz, Y., et al. (2015). Quality of life in colorectal cancer patients: An Izmir Oncology Group (IZOG) study. Journal of BUON, 20(4), 1015–1022.PubMed Akyol, M., Ulger, E., Alacacioglu, A., Kucukzeybek, Y., Bayoglu, V., Yildiz, Y., et al. (2015). Quality of life in colorectal cancer patients: An Izmir Oncology Group (IZOG) study. Journal of BUON, 20(4), 1015–1022.PubMed
34.
go back to reference Sloan, J. A., Loprinzi, C. L., Kuross, S. A., Miser, A. W., O’Fallon, J. R., Mahoney, M. R., et al. (1998). Randomized comparison of four tools measuring overall quality of life in patients with advanced cancer. Journal of Clinical Oncology, 16(11), 3662–3673.PubMed Sloan, J. A., Loprinzi, C. L., Kuross, S. A., Miser, A. W., O’Fallon, J. R., Mahoney, M. R., et al. (1998). Randomized comparison of four tools measuring overall quality of life in patients with advanced cancer. Journal of Clinical Oncology, 16(11), 3662–3673.PubMed
35.
go back to reference Hilgenfeld, R. U., Streit, M., Thiel, E., & Kreuser, E. D. (1996). Current treatment modalities in advanced colorectal carcinoma. Recent Results in Cancer Research, 142, 353–380.CrossRefPubMed Hilgenfeld, R. U., Streit, M., Thiel, E., & Kreuser, E. D. (1996). Current treatment modalities in advanced colorectal carcinoma. Recent Results in Cancer Research, 142, 353–380.CrossRefPubMed
36.
go back to reference Earlam, S., Glover, C., Fordy, C., Burke, D., & Allen-Mersh, T. G. (1996). Relation between tumor size, quality of life, and survival in patients with colorectal liver metastases. Journal of Clinical Oncology, 14(1), 171–175.PubMed Earlam, S., Glover, C., Fordy, C., Burke, D., & Allen-Mersh, T. G. (1996). Relation between tumor size, quality of life, and survival in patients with colorectal liver metastases. Journal of Clinical Oncology, 14(1), 171–175.PubMed
37.
go back to reference Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365–376.CrossRefPubMed Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365–376.CrossRefPubMed
38.
go back to reference Ward, W. L., Hahn, E. A., Mo, F., Hernandez, L., Tulsky, D. S., & Cella, D. (1999). Reliability and validity of the functional assessment of cancer therapy-colorectal (FACT-C) quality of life instrument. Quality of Life Research, 8(3), 181–195.CrossRefPubMed Ward, W. L., Hahn, E. A., Mo, F., Hernandez, L., Tulsky, D. S., & Cella, D. (1999). Reliability and validity of the functional assessment of cancer therapy-colorectal (FACT-C) quality of life instrument. Quality of Life Research, 8(3), 181–195.CrossRefPubMed
Metagegevens
Titel
Predictors of health-related quality of life and association with survival may identify colorectal cancer patients at high risk of poor prognosis
Auteurs
Monica E. Reyes
Yuanqing Ye
Yeling Zhou
Alexander Liang
Scott Kopetz
M. Alma Rodriquez
Xifeng Wu
Michelle A. T. Hildebrandt
Publicatiedatum
04-08-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 2/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1381-8