Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Quality of Life Research 1/2021

12-09-2020

Predictors for quality of life improvement after acute osteoporotic vertebral fracture: results of post hoc analysis of a prospective randomized study

Auteurs: Hiroyuki Inose, Tsuyoshi Kato, Hiroaki Nakamura, Masatoshi Hoshino, Daisuke Togawa, Toru Hirano, Yasuaki Tokuhashi, Tetsuro Ohba, Hirotaka Haro, Takashi Tsuji, Kimiaki Sato, Yutaka Sasao, Masahiko Takahata, Koji Otani, Suketaka Momoshima, Kunihiko Takahashi, Masato Yuasa, Takashi Hirai, Toshitaka Yoshii, Atsushi Okawa

Gepubliceerd in: Quality of Life Research | Uitgave 1/2021

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Purpose

No study has investigated the clinical and radiographic risk factors for the deterioration of quality of life (QOL) beyond 6 months after osteoporotic vertebral fractures (OVF). The purpose of this study was to identify the predictors associated with poor QOL improvement after OVF.

Methods

This post hoc analysis included 166 women aged 65–85 years with acute 1-level OVFs. For the patient-reported outcome measures, scores on the European Quality of Life-5 Dimensions (EQ-5D) scale, and visual analogue scale (VAS) for low back pain were used. Lateral radiography at 0, 12, and 48 weeks and magnetic resonance imaging (MRI) at enrollment and at 48 weeks were performed. The associations between baseline variables with change scores for EQ-5D were investigated using a multiple linear regression model.

Results

Univariate analysis showed that time since fracture, EQ-5D score, and VAS for low back pain at 0 week showed significant association with increased EQ-5D score from 0 to 48 weeks. According to the multiple regression analysis, the following equation was obtained: increased EQ-5D score from 0 to 48 weeks = 1.305 – 0.978 × EQ-5D at 0 week – 0.021 × VAS for low back pain at 0 week – 0.006 × age + (fluid-intensity T2-weighted MR image patterns: − 0.037, except for fluid-intensity T2-weighted MR image patterns: + 0.037).

Conclusion

In conclusion, older patients with severe low back pain and fluid-intensity T2-weighted MR image patterns were more likely to have lower QOL improvements after OVFs and may therefore need extra support to improve QOL

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Podotherapeut Totaal

Binnen de bundel kunt u gebruik maken van boeken, tijdschriften, e-learnings, web-tv's en uitlegvideo's. BSL Podotherapeut Totaal is overal toegankelijk; via uw PC, tablet of smartphone.

Literatuur
1.
go back to reference Rostom, S., Allali, F., Bennani, L., Abouqal, R., & Hajjaj-Hassouni, N. (2012). The prevalence of vertebral fractures and health-related quality of life in postmenopausal women. Rheumatology International, 32(4), 971–980. CrossRef Rostom, S., Allali, F., Bennani, L., Abouqal, R., & Hajjaj-Hassouni, N. (2012). The prevalence of vertebral fractures and health-related quality of life in postmenopausal women. Rheumatology International, 32(4), 971–980. CrossRef
2.
go back to reference Inose, H., Kato, T., Ichimura, S., Nakamura, H., Hoshino, M., Togawa, D., et al. (2020). Risk factors of nonunion after acute osteoporotic vertebral fractures: A prospective multicenter cohort study. Spine (Phila Pa 1976), 45, 895. CrossRef Inose, H., Kato, T., Ichimura, S., Nakamura, H., Hoshino, M., Togawa, D., et al. (2020). Risk factors of nonunion after acute osteoporotic vertebral fractures: A prospective multicenter cohort study. Spine (Phila Pa 1976), 45, 895. CrossRef
3.
go back to reference Haczynski, J., & Jakimiuk, A. (2001). Vertebral fractures: a hidden problem of osteoporosis. Medical Science Monitor, 7(5), 1108–1117. PubMed Haczynski, J., & Jakimiuk, A. (2001). Vertebral fractures: a hidden problem of osteoporosis. Medical Science Monitor, 7(5), 1108–1117. PubMed
4.
go back to reference Hall, S. E., Criddle, R. A., Comito, T. L., & Prince, R. L. (1999). A case-control study of quality of life and functional impairment in women with long-standing vertebral osteoporotic fracture. Osteoporosis International, 9(6), 508–515. CrossRef Hall, S. E., Criddle, R. A., Comito, T. L., & Prince, R. L. (1999). A case-control study of quality of life and functional impairment in women with long-standing vertebral osteoporotic fracture. Osteoporosis International, 9(6), 508–515. CrossRef
5.
go back to reference Paier, G. S. (1996). Specter of the crone: The experience of vertebral fracture. ANS Advances in Nursing Science, 18(3), 27–36. CrossRef Paier, G. S. (1996). Specter of the crone: The experience of vertebral fracture. ANS Advances in Nursing Science, 18(3), 27–36. CrossRef
6.
go back to reference Suzuki, N., Ogikubo, O., & Hansson, T. (2008). The course of the acute vertebral body fragility fracture: Its effect on pain, disability and quality of life during 12 months. European Spine Journal, 17(10), 1380–1390. CrossRef Suzuki, N., Ogikubo, O., & Hansson, T. (2008). The course of the acute vertebral body fragility fracture: Its effect on pain, disability and quality of life during 12 months. European Spine Journal, 17(10), 1380–1390. CrossRef
7.
go back to reference Kato, T., Inose, H., Ichimura, S., Tokuhashi, Y., Nakamura, H., Hoshino, M., et al. (2019). Comparison of rigid and soft-brace treatments for acute osteoporotic vertebral compression fracture: A prospective, randomized, Multicenter Study. J Clin Med, 8(2), 198. CrossRef Kato, T., Inose, H., Ichimura, S., Tokuhashi, Y., Nakamura, H., Hoshino, M., et al. (2019). Comparison of rigid and soft-brace treatments for acute osteoporotic vertebral compression fracture: A prospective, randomized, Multicenter Study. J Clin Med, 8(2), 198. CrossRef
8.
go back to reference Group TE. (1990). EuroQol–a new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199–208. CrossRef Group TE. (1990). EuroQol–a new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199–208. CrossRef
9.
go back to reference McCormack, H. M., Horne, D. J., & Sheather, S. (1988). Clinical applications of visual analogue scales: A critical review. Psychological Medicine, 18(4), 1007–1019. CrossRef McCormack, H. M., Horne, D. J., & Sheather, S. (1988). Clinical applications of visual analogue scales: A critical review. Psychological Medicine, 18(4), 1007–1019. CrossRef
10.
go back to reference Keynan, O., Fisher, C. G., Vaccaro, A., Fehlings, M. G., Oner, F. C., Dietz, J., et al. (2006). Radiographic measurement parameters in thoracolumbar fractures: A systematic review and consensus statement of the spine trauma study group. Spine (Phila Pa 1976), 31(5), E156–E165. CrossRef Keynan, O., Fisher, C. G., Vaccaro, A., Fehlings, M. G., Oner, F. C., Dietz, J., et al. (2006). Radiographic measurement parameters in thoracolumbar fractures: A systematic review and consensus statement of the spine trauma study group. Spine (Phila Pa 1976), 31(5), E156–E165. CrossRef
11.
go back to reference Tsujio, T., Nakamura, H., Terai, H., Hoshino, M., Namikawa, T., Matsumura, A., et al. (2011). Characteristic radiographic or magnetic resonance images of fresh osteoporotic vertebral fractures predicting potential risk for nonunion: A prospective multicenter study. Spine (Phila Pa 1976), 36(15), 1229–1235. CrossRef Tsujio, T., Nakamura, H., Terai, H., Hoshino, M., Namikawa, T., Matsumura, A., et al. (2011). Characteristic radiographic or magnetic resonance images of fresh osteoporotic vertebral fractures predicting potential risk for nonunion: A prospective multicenter study. Spine (Phila Pa 1976), 36(15), 1229–1235. CrossRef
12.
go back to reference Inose, H., Kato, T., Ichimura, S., Nakamura, H., Hoshino, M., Togawa, D., et al. (2020). Predictors of residual low back pain after acute osteoporotic compression fracture. Journal of Orthopaedic Science., S0949–2658(20), 30135–4. Inose, H., Kato, T., Ichimura, S., Nakamura, H., Hoshino, M., Togawa, D., et al. (2020). Predictors of residual low back pain after acute osteoporotic compression fracture. Journal of Orthopaedic Science., S0949–2658(20), 30135–4.
13.
go back to reference Bursac, Z., Gauss, C. H., Williams, D. K., & Hosmer, D. W. (2008). Purposeful selection of variables in logistic regression. Source Code for Biology and Medicine, 3, 17–17. CrossRef Bursac, Z., Gauss, C. H., Williams, D. K., & Hosmer, D. W. (2008). Purposeful selection of variables in logistic regression. Source Code for Biology and Medicine, 3, 17–17. CrossRef
14.
go back to reference Kasl, S. V., & Jones, B. A. (2003). An epidemiological perspective on research design, measurement, and surveillance strategies. Handbook of occupational health psychology (pp. 379–398). Washington: American Psychological Association. CrossRef Kasl, S. V., & Jones, B. A. (2003). An epidemiological perspective on research design, measurement, and surveillance strategies. Handbook of occupational health psychology (pp. 379–398). Washington: American Psychological Association. CrossRef
15.
go back to reference Team RC. (2013). R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing. Team RC. (2013). R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing.
16.
go back to reference Kanda, Y. (2013). Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplantation, 48(3), 452–458. CrossRef Kanda, Y. (2013). Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplantation, 48(3), 452–458. CrossRef
17.
go back to reference Pfeifer, M., Kohlwey, L., Begerow, B., & Minne, H. W. (2011). Effects of two newly developed spinal orthoses on trunk muscle strength, posture, and quality-of-life in women with postmenopausal osteoporosis: A randomized trial. American Journal of Physical Medicine and Rehabilitation, 90(10), 805–815. CrossRef Pfeifer, M., Kohlwey, L., Begerow, B., & Minne, H. W. (2011). Effects of two newly developed spinal orthoses on trunk muscle strength, posture, and quality-of-life in women with postmenopausal osteoporosis: A randomized trial. American Journal of Physical Medicine and Rehabilitation, 90(10), 805–815. CrossRef
18.
go back to reference Firanescu, C. E., de Vries, J., Lodder, P., Venmans, A., Schoemaker, M. C., Smeets, A. J., et al. (2018). Vertebroplasty versus sham procedure for painful acute osteoporotic vertebral compression fractures (VERTOS IV): randomised sham controlled clinical trial. BMJ, 9(361), k1551. CrossRef Firanescu, C. E., de Vries, J., Lodder, P., Venmans, A., Schoemaker, M. C., Smeets, A. J., et al. (2018). Vertebroplasty versus sham procedure for painful acute osteoporotic vertebral compression fractures (VERTOS IV): randomised sham controlled clinical trial. BMJ, 9(361), k1551. CrossRef
19.
go back to reference Hoshino, M., Takahashi, S., Yasuda, H., Terai, H., Watanabe, K., Hayashi, K., et al. (2019). Balloon kyphoplasty versus conservative treatment for acute osteoporotic vertebral fractures with poor prognostic factors: propensity score matched analysis using data from two prospective multicenter studies. Spine (Phila Pa 1976), 44(2), 110–117. CrossRef Hoshino, M., Takahashi, S., Yasuda, H., Terai, H., Watanabe, K., Hayashi, K., et al. (2019). Balloon kyphoplasty versus conservative treatment for acute osteoporotic vertebral fractures with poor prognostic factors: propensity score matched analysis using data from two prospective multicenter studies. Spine (Phila Pa 1976), 44(2), 110–117. CrossRef
20.
go back to reference Albayrak, I., Aydogmus, M., Ozerbil, O. M., & Levendoglu, F. (2016). The association between bone mineral density, quality of life, quality of sleep and fatigue. Acta Clinica Belgica, 71(2), 92–98. CrossRef Albayrak, I., Aydogmus, M., Ozerbil, O. M., & Levendoglu, F. (2016). The association between bone mineral density, quality of life, quality of sleep and fatigue. Acta Clinica Belgica, 71(2), 92–98. CrossRef
Metagegevens
Titel
Predictors for quality of life improvement after acute osteoporotic vertebral fracture: results of post hoc analysis of a prospective randomized study
Auteurs
Hiroyuki Inose
Tsuyoshi Kato
Hiroaki Nakamura
Masatoshi Hoshino
Daisuke Togawa
Toru Hirano
Yasuaki Tokuhashi
Tetsuro Ohba
Hirotaka Haro
Takashi Tsuji
Kimiaki Sato
Yutaka Sasao
Masahiko Takahata
Koji Otani
Suketaka Momoshima
Kunihiko Takahashi
Masato Yuasa
Takashi Hirai
Toshitaka Yoshii
Atsushi Okawa
Publicatiedatum
12-09-2020
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 1/2021
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02629-9