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21-01-2021 | Original Article | Uitgave 4/2021

Cognitive Therapy and Research 4/2021

Predicting and Moderating the Response to the Unified Protocol: Do Baseline Personality and Affective Profiles Matter?

Cognitive Therapy and Research > Uitgave 4/2021
J. Osma, O. Peris-Baquero, C. Suso-Ribera, S. Sauer-Zavala, D. H. Barlow
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The online version contains supplementary material available at https://​doi.​org/​10.​1007/​s10608-021-10208-6.

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Neuroticism (N), extraversion (E), and negative/positive affect (NA/PA) are personality/affective characteristics highly related to the etiology and maintenance of emotional disorders (EDs). This study aims at exploring the moderating role of baseline personality/ and affectivity profiles in the response to a transdiagnostic psychological treatment for EDs.


Outcomes were N, E, NA, PA, depression, and anxiety. These were assessed at baseline, post-treatment, and 3-month follow-up in 157 participants with EDs who received the Unified Protocol (UP) in group format in the Spanish Health System. A linear mixed model analysis was carried out to investigate different recovery trajectories as a function of baseline personality and affective profiles


Significant changes occurred in all variables after the UP. Medium and high baseline scores in N and NA moderate the largest changes on N, NA and E while lower baseline scores in PA and E moderate the largest changes on E and PA. Changes over time on depression and anxiety symptoms were not predicted from personality/affect baseline scores.


The study results support the short-medium term utility of the UP to address all study outcomes. Moreover, personalizing interventions according to baseline personality/affect might be a sensible strategy to enhance the UP effectiveness. Trial registration number NCT03064477 (March 10, 2017).

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