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Gepubliceerd in: Journal of Autism and Developmental Disorders 5/2010

01-05-2010 | Original Paper

Pre-Eclampsia, Birth Weight, and Autism Spectrum Disorders

Auteurs: Joshua R. Mann, Suzanne McDermott, Haikun Bao, James Hardin, Anthony Gregg

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2010

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Abstract

Autism spectrum disorders (ASD) are primarily inherited, but perinatal or other environmental factors may also be important. In an analysis of 87,677 births from 1996 through 2002, insured by the South Carolina Medicaid program, birth weight was significantly inversely associated with the odds of ASD (OR = 0.78, p = .001 for each additional kilogram). Maternal pre-eclampsia/eclampsia was significantly associated with greater odds of ASD (OR = 1.85, p < .0001 without controlling for birth weight; OR = 1.69, p = .0005, when controlling for birth weight). We conclude that reduced birth weight partially mediates the association between pre-eclampsia/eclampsia and ASD. Additional research is needed to investigate the potential mechanism(s) by which pre-eclampsia/eclampsia may influence ASD risk.
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Metagegevens
Titel
Pre-Eclampsia, Birth Weight, and Autism Spectrum Disorders
Auteurs
Joshua R. Mann
Suzanne McDermott
Haikun Bao
James Hardin
Anthony Gregg
Publicatiedatum
01-05-2010
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2010
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-009-0903-4