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20-05-2020 | Uitgave 10/2020

Quality of Life Research 10/2020

Potentially inappropriate medications use and its association with health-related quality of life among elderly cardiac patients

Tijdschrift:
Quality of Life Research > Uitgave 10/2020
Auteurs:
Muhammad Saqlain, Hussain Ali, Sohail Kamran, Muhammad Usman Munir, Shah Jahan, Faizan Mazhar
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11136-020-02530-5) contains supplementary material, which is available to authorized users.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Background

Previous studies identified alarming use of potentially inappropriate medications (PIMs) in Pakistani population but its effect on health-related quality of life (HRQoL) is still largely unknown.

Objective

This study aimed to determine the association between PIMs use and HRQoL among elderly cardiac outpatients.

Method

A descriptive, non-experimental, cross-sectional study was carried out from June 2018 to September 2018 in two outpatient departments of tertiary-care hospitals in the Punjab Province of Pakistan. The population under study were patients aged ≥ 65 years with at least one cardiovascular condition taking at ≥ 1 prescribed medication. Patients with PIMs were identified by using Beers criteria. HRQoL was assessed using EuroQoL-5 dimension (EQ-5D) and EuroQoL-visual analogue scale (EQ-VAS). The association of PIMs with HRQoL was analyzed using χ2 tests, independent sample t-test, and one-way ANOVA tests. Multiple linear regression analysis was used to determine how HRQoL varied by PIMs use after adjusting for patient-level covariates.

Results

Of 386 elderly cardiac patients, 260 (67.4%) patients were receiving at least one PIM. Mean EQ-5D scores were significantly lower among patients with PIMs (0.51) compared to patients without PIMs (0.65) (P < 0.001). In multiple linear regression analysis, increasing numbers of PIMs were significantly associated with lower EQ-5D scores [β =  − 0.040 (− 0.075, − 0.005), P < 0.001] and VAS scores [β =  − 1.686 (− 2.916, − 0.456), P < 0.05].

Conclusion

The present study concluded that exposure to PIM was significantly associated with lower HRQoL. This indicates that guidelines recommendations should be followed to improve patient’s quality of life.

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