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Quality of Life Research

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20-05-2020

Potentially inappropriate medications use and its association with health-related quality of life among elderly cardiac patients

Auteurs: Muhammad Saqlain, Hussain Ali, Sohail Kamran, Muhammad Usman Munir, Shah Jahan, Faizan Mazhar

Gepubliceerd in: Quality of Life Research | Uitgave 10/2020

Abstract

Background

Previous studies identified alarming use of potentially inappropriate medications (PIMs) in Pakistani population but its effect on health-related quality of life (HRQoL) is still largely unknown.

Objective

This study aimed to determine the association between PIMs use and HRQoL among elderly cardiac outpatients.

Method

A descriptive, non-experimental, cross-sectional study was carried out from June 2018 to September 2018 in two outpatient departments of tertiary-care hospitals in the Punjab Province of Pakistan. The population under study were patients aged ≥ 65 years with at least one cardiovascular condition taking at ≥ 1 prescribed medication. Patients with PIMs were identified by using Beers criteria. HRQoL was assessed using EuroQoL-5 dimension (EQ-5D) and EuroQoL-visual analogue scale (EQ-VAS). The association of PIMs with HRQoL was analyzed using χ² tests, independent sample t-test, and one-way ANOVA tests. Multiple linear regression analysis was used to determine how HRQoL varied by PIMs use after adjusting for patient-level covariates.

Results

Of 386 elderly cardiac patients, 260 (67.4%) patients were receiving at least one PIM. Mean EQ-5D scores were significantly lower among patients with PIMs (0.51) compared to patients without PIMs (0.65) (P < 0.001). In multiple linear regression analysis, increasing numbers of PIMs were significantly associated with lower EQ-5D scores [β = − 0.040 (− 0.075, − 0.005), P < 0.001] and VAS scores [β = − 1.686 (− 2.916, − 0.456), P < 0.05].

Conclusion

The present study concluded that exposure to PIM was significantly associated with lower HRQoL. This indicates that guidelines recommendations should be followed to improve patient’s quality of life.

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Titel: Potentially inappropriate medications use and its association with health-related quality of life among elderly cardiac patients
Auteurs: Muhammad Saqlain
Hussain Ali
Sohail Kamran
Muhammad Usman Munir
Shah Jahan
Faizan Mazhar
Publicatiedatum: 20-05-2020
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 10/2020
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-020-02530-5

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Abstract

Background

Objective

Method

Results

Conclusion

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